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Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Reithofer, Michael R.; Chan, Kiat-Hwa; Lakshmanan, Anupama; Lam, Dang Hoang; Mishra, Archana; Gopalan, Began; Joshi, Mangesh; Wang, Shu; Hauser, Charlotte A. E.

Authors

Michael R. Reithofer

Kiat-Hwa Chan

Anupama Lakshmanan

Dang Hoang Lam

Archana Mishra

Began Gopalan

Mangesh Joshi

Shu Wang

Charlotte A. E. Hauser

Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Journal Article Type Article
Publication Date Feb 1, 2014
Journal Chemical science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 5
Issue 2
Pages 625-630
Institution Citation Reithofer, M. R., Chan, K., Lakshmanan, A., Lam, D. H., Mishra, A., Gopalan, B., …Hauser, C. A. E. (2014). Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy. Chemical science, 5(2), 625-630. doi:10.1039/c3sc51930a
DOI https://doi.org/10.1039/c3sc51930a
Keywords Anti-cancer drugs; Ultrashort peptides; Breast cancer therapy
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/SC/C3SC51930A#!divAbstract
Copyright Statement ©2015 University of Hull
Additional Information Author's accepted manuscript of article published in: Chemical science, 2014, issue 2

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