Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Reithofer, Michael R.; Chan, Kiat-Hwa; Lakshmanan, Anupama; Lam, Dang Hoang; Mishra, Archana; Gopalan, Began; Joshi, Mangesh; Wang, Shu; Hauser, Charlotte A. E.

Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Citation

Reithofer, M. R., Chan, K.-H., Lakshmanan, A., Lam, D. H., Mishra, A., Gopalan, B., Joshi, M., Wang, S., & Hauser, C. A. E. (2014). Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy. Chemical science, 5(2), 625-630. https://doi.org/10.1039/c3sc51930a

• Journal Article Type: Article
• Acceptance Date: Oct 17, 2013
• Online Publication Date: Oct 18, 2013
• Publication Date: Feb 1, 2014
• Deposit Date: Oct 30, 2015
• Publicly Available Date: Nov 23, 2017
• Journal: Chemical science
• Print ISSN: 2041-6520
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 2
• Pages: 625-630
• DOI: https://doi.org/10.1039/c3sc51930a
• Keywords: Anti-cancer drugs; Ultrashort peptides; Breast cancer therapy
• Public URL: https://hull-repository.worktribe.com/output/380639
• Publisher URL: http://pubs.rsc.org/en/Content/ArticleLanding/2014/SC/C3SC51930A#!divAbstract
• Additional Information: Author's accepted manuscript of article published in: Chemical science, 2014, issue 2
• Contract Date: Nov 23, 2017