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Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy

Reithofer, Michael R.; Chan, Kiat-Hwa; Lakshmanan, Anupama; Lam, Dang Hoang; Mishra, Archana; Gopalan, Began; Joshi, Mangesh; Wang, Shu; Hauser, Charlotte A. E.

Authors

Michael R. Reithofer

Kiat-Hwa Chan

Anupama Lakshmanan

Dang Hoang Lam

Archana Mishra

Began Gopalan

Mangesh Joshi

Shu Wang

Charlotte A. E. Hauser



Abstract

Self-assembling ultrashort peptides from aliphatic amino acids were functionalized with platinum anti-cancer drugs by click chemistry. Oxaliplatin-derived hybrid peptide hydrogels with up to 40% drug loading were tested for localized breast cancer therapy. Stably injected gels showed significant tumor growth inhibition in mice and a better tolerance compared to the free platinum drug.

Citation

Reithofer, M. R., Chan, K., Lakshmanan, A., Lam, D. H., Mishra, A., Gopalan, B., …Hauser, C. A. E. (2014). Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy. Chemical science, 5(2), 625-630. https://doi.org/10.1039/c3sc51930a

Journal Article Type Article
Acceptance Date Oct 17, 2013
Online Publication Date Oct 18, 2013
Publication Date Feb 1, 2014
Deposit Date Oct 30, 2015
Publicly Available Date Nov 23, 2017
Journal Chemical science
Print ISSN 2041-6520
Electronic ISSN 2041-6539
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 5
Issue 2
Pages 625-630
DOI https://doi.org/10.1039/c3sc51930a
Keywords Anti-cancer drugs; Ultrashort peptides; Breast cancer therapy
Public URL https://hull-repository.worktribe.com/output/380639
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2014/SC/C3SC51930A#!divAbstract
Copyright Statement ©2015 University of Hull
Additional Information Author's accepted manuscript of article published in: Chemical science, 2014, issue 2

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