Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
(2013)
Journal Article
Arima, V., Pascali, G., Lade, O., Kretschmer, H. R., Bernsdorf, I., Hammond, V., Watts, P., De Leonardis, F., Tarn, M. D., Cvetkovic, B. Z., Dittrich, P. S., Vasovic, N., Duane, R., Jaksic, A., Pamme, N., Zacheo, A., Zizzari, A., Marra, L., Perrone, E., Salvadori, P. A., & Rinaldi, R. (2013). Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab on a chip, 13(12), 2328-2336. https://doi.org/10.1039/c3lc00055a
We have developed an integrated microfluidic platform for producing 2-[¹⁸F]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that... Read More about Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals.