Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

Arima, Valentina; Pascali, Giancarlo; Lade, Oliver; Kretschmer, Hans R.; Bernsdorf, Ingo; Hammond, Victoria; Watts, Paul; De Leonardis, Francesco; Tarn, Mark D.; Cvetkovic, Benjamin Z.; Dittrich, Petra S.; Vasovic, Nikola; Duane, Russell; Jaksic, Aleksandar; Pamme, Nicole; Zacheo, Antonella; Zizzari, Alessandra; Marra, Lucia; Perrone, Elisabetta; Salvadori, Piero A.; Rinaldi, Rosaria

doi:10.1039/c3lc00055a

Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

Arima, Valentina; Pascali, Giancarlo; Lade, Oliver; Kretschmer, Hans R.; Bernsdorf, Ingo; Hammond, Victoria; Watts, Paul; De Leonardis, Francesco; Tarn, Mark D.; Cvetkovic, Benjamin Z.; Dittrich, Petra S.; Vasovic, Nikola; Duane, Russell; Jaksic, Aleksandar; Pamme, Nicole; Zacheo, Antonella; Zizzari, Alessandra; Marra, Lucia; Perrone, Elisabetta; Salvadori, Piero A.; Rinaldi, Rosaria

Authors

Valentina Arima

Giancarlo Pascali

Oliver Lade

Hans R. Kretschmer

Ingo Bernsdorf

Victoria Hammond

Paul Watts

Francesco De Leonardis

Mark D. Tarn

Benjamin Z. Cvetkovic

Petra S. Dittrich

Nikola Vasovic

Russell Duane

Aleksandar Jaksic

Nicole Pamme

Antonella Zacheo

Alessandra Zizzari

Lucia Marra

Elisabetta Perrone

Piero A. Salvadori

Rosaria Rinaldi

Abstract

We have developed an integrated microfluidic platform for producing 2-[¹⁸F]-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) in continuous flow from a single bolus of radioactive isotope solution, with constant product yields achieved throughout the operation that were comparable to those reported for commercially available vessel-based synthesisers (40–80%). The system would allow researchers to obtain radiopharmaceuticals in a dose-on-demand setting within a few minutes. The flexible architecture of the platform, based on a modular design, can potentially be applied to the synthesis of other radiotracers that require a two-step synthetic approach, and may be adaptable to more complex synthetic routes by implementing additional modules. It can therefore be employed for standard synthesis protocols as well as for research and development of new radiopharmaceuticals.

Citation

Arima, V., Pascali, G., Lade, O., Kretschmer, H. R., Bernsdorf, I., Hammond, V., Watts, P., De Leonardis, F., Tarn, M. D., Cvetkovic, B. Z., Dittrich, P. S., Vasovic, N., Duane, R., Jaksic, A., Pamme, N., Zacheo, A., Zizzari, A., Marra, L., Perrone, E., Salvadori, P. A., & Rinaldi, R. (2013). Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab on a chip, 13(12), 2328-2336. https://doi.org/10.1039/c3lc00055a

Journal Article Type	Article
Acceptance Date	Mar 25, 2013
Online Publication Date	Mar 25, 2013
Publication Date	2013
Deposit Date	Nov 13, 2014
Journal	Lab On A Chip
Print ISSN	1473-0197
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
Volume	13
Issue	12
Pages	2328-2336
DOI	https://doi.org/10.1039/c3lc00055a
Keywords	Biochemistry; Bioengineering; General Chemistry; Biomedical Engineering
Public URL	https://hull-repository.worktribe.com/output/473222
Publisher URL	http://pubs.rsc.org/en/Content/ArticleLanding/2013/LC/c3lc00055a#!divAbstract
Contract Date	Nov 13, 2014