L. L. Woodcock
Enzymatic synthesis of a series of alkyl esters using novozyme 435 in a packed-bed, miniaturized, continuous flow reactor
Woodcock, L. L.; Wiles, C.; Greenway, G. M.; Watts, P.; Wells, A.; Eyley, S.
Authors
C. Wiles
G. M. Greenway
P. Watts
A. Wells
S. Eyley
Abstract
Using lipase catalysed, enzymatic esterification as a model reaction, we successfully demonstrate the use of miniaturized technology for biocatalytic reactions. Benchmarked against batch reactions, nine alkyl esters have been synthesized effectively, using Novozyme 435 in a pressure driven, packed-bed, miniaturized, continuous flow reactor. In some cases close to 100% ester conversions were obtained. The paper also demonstrates the ability to screen the enzyme for substrate specificity.
Citation
Woodcock, L. L., Wiles, C., Greenway, G. M., Watts, P., Wells, A., & Eyley, S. (2008). Enzymatic synthesis of a series of alkyl esters using novozyme 435 in a packed-bed, miniaturized, continuous flow reactor. Biocatalysis and biotransformation, 26(6), 466-472. https://doi.org/10.1080/10242420802456571
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 31, 2008 |
Online Publication Date | Jul 11, 2009 |
Publication Date | 2008-01 |
Journal | BIOCATALYSIS AND BIOTRANSFORMATION |
Print ISSN | 1024-2422 |
Electronic ISSN | 1029-2446 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 26 |
Issue | 6 |
Pages | 466-472 |
DOI | https://doi.org/10.1080/10242420802456571 |
Keywords | Biotechnology; Biochemistry; Catalysis |
Public URL | https://hull-repository.worktribe.com/output/391251 |
Publisher URL | https://www.tandfonline.com/doi/full/10.1080/10242420802456571 |
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