L. L. Woodcock
Enzymatic synthesis of a series of alkyl esters using novozyme 435 in a packed-bed, miniaturized, continuous flow reactor
Woodcock, L. L.; Wiles, C.; Greenway, G. M.; Watts, P.; Wells, A.; Eyley, S.
G. M. Greenway G.M.Greenway@hull.ac.uk
Using lipase catalysed, enzymatic esterification as a model reaction, we successfully demonstrate the use of miniaturized technology for biocatalytic reactions. Benchmarked against batch reactions, nine alkyl esters have been synthesized effectively, using Novozyme 435 in a pressure driven, packed-bed, miniaturized, continuous flow reactor. In some cases close to 100% ester conversions were obtained. The paper also demonstrates the ability to screen the enzyme for substrate specificity.
Woodcock, L. L., Wiles, C., Greenway, G. M., Watts, P., Wells, A., & Eyley, S. (2008). Enzymatic synthesis of a series of alkyl esters using novozyme 435 in a packed-bed, miniaturized, continuous flow reactor. Biocatalysis and biotransformation, 26(6), 466-472. https://doi.org/10.1080/10242420802456571
|Journal Article Type||Article|
|Acceptance Date||Dec 31, 2008|
|Online Publication Date||Jul 11, 2009|
|Publicly Available Date|
|Journal||BIOCATALYSIS AND BIOTRANSFORMATION|
|Publisher||Taylor & Francis|
|Peer Reviewed||Peer Reviewed|
|Keywords||Biotechnology; Biochemistry; Catalysis|
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