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PDMS Microfluidic Device with an Integrated Optical Sensor for Determination of Zinc (II) in Pharmaceuticals: Toward the Production of Miniaturized Green Chemistry Analytical Systems

AlSuhaimi, Awadh; Greenway, Gullian M.; McCreedy, Tom; Youngvises, Napaporn

Authors

Awadh AlSuhaimi

Gullian M. Greenway G.M.Greenway@hull.ac.uk

Tom McCreedy T.McCreedy@hull.ac.uk

Napaporn Youngvises



Abstract

A simple miniaturized system was fabricated in general laboratory from polydimethylsiloxane (PDMS) according to a prototype casting and molding process permitting the construction of three-dimensional (3D) microchannel (100 mu m i.d.) with T-type network, together with an integrated optical sensor for on chip detection. The fabricated device has been successfully applied as a green chemistry-compatible miniaturized analytical system for the determination of zinc (II) in pharmaceutical samples taking the advantage of the colorimetric reaction of zinc (II) and xylenol orange in acetate buffer at pH 5.5. The microfluidic device is a convenient way to quantify zinc (II) over a wide dynamic range, 0.2-2.5 mu gmL-1, with good linearity (R2 0.9940).

Citation

AlSuhaimi, A., Greenway, G. M., McCreedy, T., & Youngvises, N. (in press). PDMS Microfluidic Device with an Integrated Optical Sensor for Determination of Zinc (II) in Pharmaceuticals: Toward the Production of Miniaturized Green Chemistry Analytical Systems. Spectroscopy letters, 42(6-7), 370-375. https://doi.org/10.1080/00387010903187260

Journal Article Type Article
Acceptance Date Dec 2, 2008
Online Publication Date Dec 1, 2009
Journal SPECTROSCOPY LETTERS
Print ISSN 0038-7010
Electronic ISSN 1532-2289
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 42
Issue 6-7
Pages 370-375
DOI https://doi.org/10.1080/00387010903187260
Public URL https://hull-repository.worktribe.com/output/391358