All Outputs (3)

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease (2019)
Journal Article
Williams, H. F., Mellows, B. A., Mitchell, R., Sfyri, P., Layfield, H. J., Salamah, M., Vaiyapuri, R., Collins-Hooper, H., Bicknell, A. B., Matsakas, A., Patel, K., & Vaiyapuri, S. (2019). Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease. PLoS Neglected Tropical Diseases, 13(1), Article e0007041. https://doi.org/10.1371/journal.pntd.0007041

Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year. Snakebite envenomation also causes innumerable morbidities specifically loss... Read More about Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease.

Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury (2018)
Journal Article
Scully, D., Sfyri, P., Verpoorten, S., Papadopoulos, P., Muñoz-Turrillas, M. C., Mitchell, R., Aburima, A., Patel, K., Gutiérrez, L., Naseem, K. M., & Matsakas, A. (2019). Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury. Acta Physiologica, 225(3), Article e13207. https://doi.org/10.1111/apha.13207

Aim

The use of platelets as biomaterials has gained intense research interest. However, the mechanisms regarding platelet‐mediated skeletal myogenesis remain to be established. The aim of this study was to determine the role of platelet releasate in... Read More about Platelet releasate promotes skeletal myogenesis by increasing muscle stem cell commitment to differentiation and accelerates muscle regeneration following acute injury.

Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease (2017)
Journal Article
Sfyri, P., & Matsakas, A. (2017). Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease. Journal of Biomedical Science, 24(1), Article ARTN 42. https://doi.org/10.1186/s12929-017-0346-8

Atherosclerosis is a chronic inflammatory process that, in the presence of hyperlipidaemia, promotes the formation of atheromatous plaques in large vessels of the cardiovascular system. It also affects peripheral arteries with major implications for... Read More about Crossroads between peripheral atherosclerosis, western-type diet and skeletal muscle pathophysiology: emphasis on apolipoprotein E deficiency and peripheral arterial disease.