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Proceedings: SimBio-M 2024 (ed. Peter Zioupos, Christophe Bastien) (2024)
Presentation / Conference Contribution
(2024, September). Proceedings: SimBio-M 2024 (ed. Peter Zioupos, Christophe Bastien). Presented at SimBio-M 2024, Online

This conference introduces new technologies, advances and tools in the various fields of Simulation in Biosciences and Multiphysics, notably in the areas of BioMechanics, BioMaterials, and BioMedicine.

While the conference concentrates mainly on t... Read More about Proceedings: SimBio-M 2024 (ed. Peter Zioupos, Christophe Bastien).

Predicting the Fracture Toughness of Human Cancellous Bone in Fractured Neck of Femur Patients Using Bone Volume and Micro-Architecture (2024)
Journal Article
Adams, G. J., Cook, R. B., Gibson, M., & Zioupos, P. (2024). Predicting the Fracture Toughness of Human Cancellous Bone in Fractured Neck of Femur Patients Using Bone Volume and Micro-Architecture. Life, 14(4), Article 467. https://doi.org/10.3390/life14040467

The current protocol used to determine if an individual is osteoporotic relies on assessment of the individual’s bone mineral density (BMD), which allows clinicians to judge the condition of a patient with respect to their peers. This, in essence, ev... Read More about Predicting the Fracture Toughness of Human Cancellous Bone in Fractured Neck of Femur Patients Using Bone Volume and Micro-Architecture.

Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery (2024)
Journal Article
Cai, Y., Pascoletti, G., Zioupos, P., Budair, B., Zanetti, E. M., Ringrose, T. J., & Junaid, S. (2024). Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery. Life, 14(3), Article 328. https://doi.org/10.3390/life14030328

Introduction: Flatfoot is a condition commonly seen in children; however, there is general disagreement over its incidence, characterization and correction. Painful flatfoot accompanied with musculoskeletal and soft tissue problems requires surgery t... Read More about Parametrization of the Calcaneus and Medial Cuneiform to Aid Potential Advancements in Flatfoot Surgery.

Wet Bone Characteristics Persist in Buried Bone after 10 Weeks: Implications for Forensic Anthropology (2023)
Journal Article
Maier, A. K., Manzella, A., Bonicelli, A., Arnold, E. L., Márquez-Grant, N., & Zioupos, P. (2023). Wet Bone Characteristics Persist in Buried Bone after 10 Weeks: Implications for Forensic Anthropology. Forensic Sciences, 3(3), 491-505. https://doi.org/10.3390/forensicsci3030034

Assessing the timing of skeletal trauma significantly impacts the reconstruction of events surrounding death and deposition in forensic cases. However, there are no absolute time frames in which the characteristics of wet bone (peri-mortem) fractures... Read More about Wet Bone Characteristics Persist in Buried Bone after 10 Weeks: Implications for Forensic Anthropology.

Feasibility of additively manufacturing synthetic bone for sports personal protective equipment applications (2023)
Journal Article
Leslie, G., Winwood, K., Sanderson, A., Zioupos, P., & Allen, T. (2023). Feasibility of additively manufacturing synthetic bone for sports personal protective equipment applications. Annals of 3D Printed Medicine, 12, Article 100121. https://doi.org/10.1016/j.stlm.2023.100121

Human limb surrogates, of varying biofidelity, are used in the performance assessment of sports personal protective equipment (PPE). Such biofidelic surrogates have incorporated soft tissue simulants (silicones) and synthetic bone (short fibre filled... Read More about Feasibility of additively manufacturing synthetic bone for sports personal protective equipment applications.

Quantifying microcracks on fractured bone surfaces – Potential use in forensic anthropology (2023)
Journal Article
Walden, S. J., Rowe, W., Mulville, J., Evans, S. L., & Zioupos, P. (2023). Quantifying microcracks on fractured bone surfaces – Potential use in forensic anthropology. Journal of the mechanical behavior of biomedical materials, 142, Article 105824. https://doi.org/10.1016/j.jmbbm.2023.105824

Bone fracture surface morphology (FSM) can provide valuable information on the cause of failure in forensic and archaeological applications and it depends primarily on three factors, the loading conditions (like strain rate), the ambient conditions (... Read More about Quantifying microcracks on fractured bone surfaces – Potential use in forensic anthropology.

Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures (2023)
Journal Article
Bonicelli, A., Tay, T., Cobb, J. P., Boughton, O. R., Hansen, U., Abel, R. L., & Zioupos, P. (2023). Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures. Journal of the mechanical behavior of biomedical materials, 138, Article 105573. https://doi.org/10.1016/j.jmbbm.2022.105573

Measurement of the properties of bone as a material can happen in various length scales in its hierarchical and composite structure. The aim of this study was to test the tissue level properties of clinically-relevant human bone samples which were co... Read More about Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures.

The interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: Predictions from a 3D computational model (2022)
Journal Article
Berli, M., Franco, F., Di Paolo, J., Zioupos, P., & Borau, C. (2022). The interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: Predictions from a 3D computational model. Computers in biology and medicine, 148, Article 105898. https://doi.org/10.1016/j.compbiomed.2022.105898

Bone mechanical and biological properties are closely linked to its internal tissue composition and mass distribution, which are in turn governed by the purposeful action of the basic multicellular units (BMUs). The orchestrated action of osteoclasts... Read More about The interplay between BMU activity linked to mechanical stress, specific surface and inhibitory theory dictate bone mass distribution: Predictions from a 3D computational model.

Microarchitecture and morphology of bone tissue over a wide range of BV/TV assessed by micro-computed tomography and three different threshold backgrounds (2022)
Journal Article
Adams, G., Cook, R., Hutchinson, J., & Zioupos, P. (2022). Microarchitecture and morphology of bone tissue over a wide range of BV/TV assessed by micro-computed tomography and three different threshold backgrounds. Medical engineering & physics, 106, Article 103828. https://doi.org/10.1016/j.medengphy.2022.103828

The microarchitecture of bone both results from and in turn affects the remodelling process. Bone-specific surface, for instance, is one of these important microarchitectural parameters because remodelling is also considered to be a surface-mediated... Read More about Microarchitecture and morphology of bone tissue over a wide range of BV/TV assessed by micro-computed tomography and three different threshold backgrounds.

Assessing bone maturity: Compositional and mechanical properties of rib cortical bone at different ages (2021)
Journal Article
Bonicelli, A., Kranioti, E. F., Xhemali, B., Arnold, E., & Zioupos, P. (2022). Assessing bone maturity: Compositional and mechanical properties of rib cortical bone at different ages. Bone, 155, Article 116265. https://doi.org/10.1016/j.bone.2021.116265

Understanding what maturity entails for bone, when it arrives, and its pre- and post-maturity traits and properties are very important for understanding its evolution and physiology. There is a clear but fine distinction between the chronological age... Read More about Assessing bone maturity: Compositional and mechanical properties of rib cortical bone at different ages.

A Generic Brain Trauma Computer Framework to Assess Brain Injury Severity and Bridging Vein Rupture in Traumatic Falls (2021)
Journal Article
Bastien, C., Sturgess, C. N., Davies, H., Hardwicke, J., Cloake, T., & Zioupos, P. (2021). A Generic Brain Trauma Computer Framework to Assess Brain Injury Severity and Bridging Vein Rupture in Traumatic Falls. Journal of Head Neck & Spine Surgery, 4(4), 47-60. https://doi.org/10.19080/jhnss.2021.04.555641

Traumatic Brain Injuries (TBI) have been a major cause of morbidity and mortality for many years. The Organ Trauma Model (OTM) is a state of the art computer model, available to scientific community, which can calculate the threat to the life via whi... Read More about A Generic Brain Trauma Computer Framework to Assess Brain Injury Severity and Bridging Vein Rupture in Traumatic Falls.

Age related changes of rib cortical bone matrix and the application to forensic age-at-death estimation (2021)
Journal Article
Bonicelli, A., Zioupos, P., Arnold, E., Rogers, K. D., Xhemali, B., & Kranioti, E. F. (2021). Age related changes of rib cortical bone matrix and the application to forensic age-at-death estimation. Scientific reports, 11(1), Article 2086. https://doi.org/10.1038/s41598-021-81342-0

Forensic anthropology includes, amongst other applications, the positive identification of unknown human skeletal remains. The first step in this process is an assessment of the biological profile, that is: sex, age, stature and ancestry. In forensic... Read More about Age related changes of rib cortical bone matrix and the application to forensic age-at-death estimation.

Spinal Motion Segments — II: Tuning and Optimisation for Biofidelic Performance (2020)
Journal Article
Franceskides, C., Arnold, E., Horsfall, I., Tozzi, G., Gibson, M. C., & Zioupos, P. (2020). Spinal Motion Segments — II: Tuning and Optimisation for Biofidelic Performance. Journal of Bionic Engineering, 17(4), 757-766. https://doi.org/10.1007/s42235-020-0061-0

Most commercially available spine analogues are not intended for biomechanical testing, and the few that are suitable for using in conjunction with implants and devices to allow a hands-on practice on operative procedures are very expensive and still... Read More about Spinal Motion Segments — II: Tuning and Optimisation for Biofidelic Performance.

Spinal Motion Segments — I: Concept for a Subject-specific Analogue Model (2020)
Journal Article
Franceskides, C., Arnold, E., Horsfall, I., Tozzi, G., Gibson, M. C., & Zioupos, P. (2020). Spinal Motion Segments — I: Concept for a Subject-specific Analogue Model. Journal of Bionic Engineering, 17(4), 747-756. https://doi.org/10.1007/s42235-020-0060-1

Most commercial spine analogues are not intended for biomechanical testing, and those developed for this purpose are expensive and yet still fail to replicate the mechanical performance of biological specimens. Patient-specific analogues that address... Read More about Spinal Motion Segments — I: Concept for a Subject-specific Analogue Model.

Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science? (2020)
Journal Article
McGivern, H., Greenwood, C., Márquez-Grant, N., Kranioti, E. F., Xhemali, B., & Zioupos, P. (2020). Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science?. Frontiers in Bioengineering and Biotechnology, 7, Article 467. https://doi.org/10.3389/fbioe.2019.00467

The mechanical and structural properties of bone are known to change significantly with age. Within forensic and archaeological investigations, the medial end of the clavicle is typically used for estimating the age-at-death of an unknown individual.... Read More about Age-Related Trends in the Trabecular Micro-Architecture of the Medial Clavicle: Is It of Use in Forensic Science?.

Ageing bone fractures: The case of a ductile to brittle transition that shifts with age (2019)
Journal Article
Zioupos, P., Kirchner, H. O., & Peterlik, H. (2020). Ageing bone fractures: The case of a ductile to brittle transition that shifts with age. Bone, 131, Article 115176. https://doi.org/10.1016/j.bone.2019.115176

Human bone becomes increasingly brittle with ageing. Bones also fracture differently under slow and fast loadings, being ductile and brittle, respectively. The effects of a combination of these two factors have never been examined before. Here we sho... Read More about Ageing bone fractures: The case of a ductile to brittle transition that shifts with age.

Evaluation of bone excision effects on a human skull model—II: Finite element analysis (2019)
Journal Article
Franceskides, C., Gibson, M., & Zioupos, P. (2020). Evaluation of bone excision effects on a human skull model—II: Finite element analysis. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 234(4), 346-355. https://doi.org/10.1177/0954411919892799

Patient-specific computational models are powerful tools which may assist in predicting the outcome of invasive surgery on the musculoskeletal system, and consequently help to improve therapeutic decision-making and post-operative care. Unfortunately... Read More about Evaluation of bone excision effects on a human skull model—II: Finite element analysis.

Evaluation of bone excision effects on a human skull model – I: Mechanical testing and digital image correlation (2019)
Journal Article
Franceskides, C., Leger, T., Horsfall, I., Tozzi, G., Gibson, M., & Zioupos, P. (2020). Evaluation of bone excision effects on a human skull model – I: Mechanical testing and digital image correlation. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 234(4), 337-345. https://doi.org/10.1177/0954411919891885

The mechanisms of skull impact loading may change following surgical interventions such as the removal of bone lesions, but little is known about the consequences in the event of subsequent head trauma. We, therefore, prepared acrylonitrile butadiene... Read More about Evaluation of bone excision effects on a human skull model – I: Mechanical testing and digital image correlation.

Strain rate dependence of work of fracture tests on bone and similar tissues: Reflections on testing methods and mineral content effects (2019)
Journal Article
Currey, J. D., Brear, K., & Zioupos, P. (2019). Strain rate dependence of work of fracture tests on bone and similar tissues: Reflections on testing methods and mineral content effects. Bone, 128, Article 115038. https://doi.org/10.1016/j.bone.2019.115038

This paper is concerned with the effect of different strain rate on the Work of Fracture (Wf) of various vertebrate mineralised tissues, controlling for the effect of mineral content and Young's modulus of elasticity. Using specimens of uniform shape... Read More about Strain rate dependence of work of fracture tests on bone and similar tissues: Reflections on testing methods and mineral content effects.