All Outputs (4)

Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole (2010)
Journal Article
Sparke, A. E., Fisher, C. M., Mewis, R. E., & Archibald, S. J. (2010). Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole. Tetrahedron letters; the international organ for the rapid publication of preliminary communications in organic chemistry, 51(36), 4723-4726. https://doi.org/10.1016/j.tetlet.2010.07.010

The synthesis of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole, which undergoes a nucleophilic substitution with pyridine in the absence of additional base, is reported. The key steps are the reaction of 1,2-phenylenediamine to give exclusively the... Read More about Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole.

A cellular screening assay using analysis of metal-modified fluorescence lifetime (2010)
Journal Article
Cade, N. I., Fruhwirth, G., Archibald, S. J., Ng, T., & Richards, D. (2010). A cellular screening assay using analysis of metal-modified fluorescence lifetime. Biophysical journal, 98(11), 2752-2757. https://doi.org/10.1016/j.bpj.2010.03.016

Current methods for screening cell receptor internalization often require complex image analysis with limited sensitivity. Here we describe a novel bioassay based on detection of changes in global fluorescence lifetime above a gold substrate, with su... Read More about A cellular screening assay using analysis of metal-modified fluorescence lifetime.

Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives (2010)
Journal Article
Jha, S., Silversides, J. D., Boyle, R. W., & Archibald, S. J. (2010). Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives. CrystEngComm RSC, 12(6), 1730-1739. https://doi.org/10.1039/b924683e

Hydantoins have been known as medicinally active compounds since the 1940s and thiohydantoin derivatives are currently undergoing clinical trials as potent androgen receptor antagonist drugs. Control of solid state properties including the formation... Read More about Hydrogen bonded dimers vs. one-dimensional chains in 2-thiooxoimidazolidin-4-one (thiohydantoin) drug derivatives.

Biomedical applications of macrocyclic ligand complexes (2010)
Journal Article
Mewis, R. E., & Archibald, S. J. (2010). Biomedical applications of macrocyclic ligand complexes. Coordination chemistry reviews, 254(15-16), 1686-1712. https://doi.org/10.1016/j.ccr.2010.02.025

Macrocyclic chelators can form highly stable complexes with transition metals and lanthanides. In this review, the recent advances towards biomedical applications of macrocyclic complexes are outlined. The use of such complexes in imaging as MRI cont... Read More about Biomedical applications of macrocyclic ligand complexes.