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Biomedical applications of macrocyclic ligand complexes

Mewis, Ryan E.; Archibald, Stephen J.


Ryan E. Mewis


Macrocyclic chelators can form highly stable complexes with transition metals and lanthanides. In this review, the recent advances towards biomedical applications of macrocyclic complexes are outlined. The use of such complexes in imaging as MRI contrast agents, radiopharmaceuticals and luminescent probes is discussed. The considerable scope for future development of novel metal based therapeutics based on protein binding, targeting of radioisotopes or dual function agents is also highlighted. (C) 2010 Elsevier B.V. All rights reserved.

Journal Article Type Review
Publication Date 2010-08
Print ISSN 0010-8545
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 254
Issue 15-16
Pages 1686-1712
APA6 Citation Mewis, R. E., & Archibald, S. J. (2010). Biomedical applications of macrocyclic ligand complexes. Coordination chemistry reviews, 254(15-16), 1686-1712.
Keywords Macrocycle; Azamacrocycle; Medicinal; MRI; PET; Radiopharmaceutical
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