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Biomedical applications of macrocyclic ligand complexes

Mewis, Ryan E.; Archibald, Stephen J.

Authors

Ryan E. Mewis



Abstract

Macrocyclic chelators can form highly stable complexes with transition metals and lanthanides. In this review, the recent advances towards biomedical applications of macrocyclic complexes are outlined. The use of such complexes in imaging as MRI contrast agents, radiopharmaceuticals and luminescent probes is discussed. The considerable scope for future development of novel metal based therapeutics based on protein binding, targeting of radioisotopes or dual function agents is also highlighted. (C) 2010 Elsevier B.V. All rights reserved.

Citation

Mewis, R. E., & Archibald, S. J. (2010). Biomedical applications of macrocyclic ligand complexes. Coordination chemistry reviews, 254(15-16), 1686-1712. https://doi.org/10.1016/j.ccr.2010.02.025

Journal Article Type Review
Acceptance Date Feb 25, 2010
Online Publication Date Mar 3, 2010
Publication Date 2010-08
Journal COORDINATION CHEMISTRY REVIEWS
Print ISSN 0010-8545
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 254
Issue 15-16
Pages 1686-1712
DOI https://doi.org/10.1016/j.ccr.2010.02.025
Keywords Macrocycle; Azamacrocycle; Medicinal; MRI; PET; Radiopharmaceutical
Public URL https://hull-repository.worktribe.com/output/400145
Publisher URL https://www.sciencedirect.com/science/article/pii/S0010854510000652?via%3Dihub