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The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Archibald, Stephen J.; Allott, Louis

Authors

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Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics



Abstract

The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.

Citation

Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), https://doi.org/10.1186/s41181-021-00141-0

Journal Article Type Review
Acceptance Date Jul 22, 2021
Online Publication Date Aug 26, 2021
Publication Date Dec 1, 2021
Deposit Date Aug 27, 2021
Publicly Available Date Aug 27, 2021
Journal EJNMMI Radiopharmacy and Chemistry
Electronic ISSN 2365-421X
Publisher SpringerOpen
Peer Reviewed Peer Reviewed
Volume 6
Issue 1
Article Number 30
DOI https://doi.org/10.1186/s41181-021-00141-0
Keywords Aluminium-[18F]fluoride; [18F]AlF Radiometal; Chelation; Radioconjugate
Public URL https://hull-repository.worktribe.com/output/3827689

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Copyright Statement
© The Author(s), 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits
use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original
author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third
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