Professor Steve Archibald S.J.Archibald@hull.ac.uk
Professor in Molecular Imaging
The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules
Archibald, Stephen J.; Allott, Louis
Authors
Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics
Abstract
The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.
Citation
Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30. https://doi.org/10.1186/s41181-021-00141-0
Journal Article Type | Review |
---|---|
Acceptance Date | Jul 22, 2021 |
Online Publication Date | Aug 26, 2021 |
Publication Date | Dec 1, 2021 |
Deposit Date | Aug 27, 2021 |
Publicly Available Date | Aug 27, 2021 |
Journal | EJNMMI Radiopharmacy and Chemistry |
Electronic ISSN | 2365-421X |
Publisher | SpringerOpen |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 1 |
Article Number | 30 |
DOI | https://doi.org/10.1186/s41181-021-00141-0 |
Keywords | Aluminium-[18F]fluoride; [18F]AlF Radiometal; Chelation; Radioconjugate |
Public URL | https://hull-repository.worktribe.com/output/3827689 |
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© The Author(s), 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits
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author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third
party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or
exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://
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