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The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Archibald, Stephen J.; Allott, Louis


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Dr Louis Allott
Lecturer in Translational Radiopharmaceutics


The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.


Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30.

Journal Article Type Review
Acceptance Date Jul 22, 2021
Online Publication Date Aug 26, 2021
Publication Date Dec 1, 2021
Deposit Date Aug 27, 2021
Publicly Available Date Aug 27, 2021
Journal EJNMMI Radiopharmacy and Chemistry
Electronic ISSN 2365-421X
Publisher SpringerOpen
Peer Reviewed Peer Reviewed
Volume 6
Issue 1
Article Number 30
Keywords Aluminium-[18F]fluoride; [18F]AlF Radiometal; Chelation; Radioconjugate
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