The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules

Archibald, Stephen J.; Allott, Louis

doi:10.1186/s41181-021-00141-0

Authors

Professor Steve Archibald S.J.Archibald@hull.ac.uk
Professor in Molecular Imaging

Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics

Abstract

The aluminium-[18F]fluoride ([18F]AlF) radiolabelling method combines the favourable decay characteristics of fluorine-18 with the convenience and familiarity of metal-based radiochemistry and has been used to parallel gallium-68 radiopharmaceutical developments. As such, the [18F]AlF method is popular and widely implemented in the development of radiopharmaceuticals for the clinic. In this review, we capture the current status of [18F]AlF-based technology and reflect upon its impact on nuclear medicine, as well as offering our perspective on what the future holds for this unique radiolabelling method.

Citation

Archibald, S. J., & Allott, L. (2021). The aluminium-[18F]fluoride revolution: simple radiochemistry with a big impact for radiolabelled biomolecules. EJNMMI Radiopharmacy and Chemistry, 6(1), Article 30. https://doi.org/10.1186/s41181-021-00141-0

Journal Article Type	Review
Acceptance Date	Jul 22, 2021
Online Publication Date	Aug 26, 2021
Publication Date	Dec 1, 2021
Deposit Date	Aug 27, 2021
Publicly Available Date	Oct 27, 2022
Journal	EJNMMI Radiopharmacy and Chemistry
Electronic ISSN	2365-421X
Publisher	SpringerOpen
Peer Reviewed	Peer Reviewed
Volume	6
Issue	1
Article Number	30
DOI	https://doi.org/10.1186/s41181-021-00141-0
Keywords	Aluminium-[18F]fluoride; [18F]AlF Radiometal; Chelation; Radioconjugate
Public URL	https://hull-repository.worktribe.com/output/3827689

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