Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform

Yang, Zixuan; Barnes, Chris; Domarkas, Juozas; Koch-Paszkowski, Joanna; Wright, John; Amgheib, Ala; Renard, Isaline; Fu, Ruisi; Archibald, Stephen; Aboagye, Eric O.; Allott, Louis

Abstract

Sulfur-[18F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [18F]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([18F]5) using the GE FASTLab™ cassette-based platform in a 25.0 ± 2.6% radiochemical yield (decay corrected). Uptake in vitro and in vivo correlated with PSMA expression, and the radioligand exhibited favourable biodistribution and pharmacokinetic profiles.

Citation

Yang, Z., Barnes, C., Domarkas, J., Koch-Paszkowski, J., Wright, J., Amgheib, A., Renard, I., Fu, R., Archibald, S., Aboagye, E. O., & Allott, L. (2023). Automated sulfur-[18F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform. Reaction Chemistry and Engineering, 8(10), 2403-2407. https://doi.org/10.1039/d3re00307h

• Journal Article Type: Article
• Acceptance Date: Aug 17, 2023
• Online Publication Date: Aug 21, 2023
• Publication Date: Oct 1, 2023
• Deposit Date: Aug 30, 2023
• Publicly Available Date: Aug 31, 2023
• Journal: Reaction Chemistry and Engineering
• Print ISSN: 2058-9883
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Issue: 10
• Pages: 2403-2407
• DOI: https://doi.org/10.1039/d3re00307h
• Public URL: https://hull-repository.worktribe.com/output/4371622