Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Baghdadi, Neazar E.; Burke, Benjamin P.; Alresheedi, Tahani; Nigam, Shubhanchi; Saeed, Abdu; Almutairi, Farooq; Domarkas, Juozas; Khan, Abid; Archibald, Stephen J.

Abstract

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

Citation

Baghdadi, N. E., Burke, B. P., Alresheedi, T., Nigam, S., Saeed, A., Almutairi, F., …Archibald, S. J. (2021). Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. Dalton Transactions : an international journal of inorganic chemistry, 50(5), 1599-1603. https://doi.org/10.1039/d0dt02626c

• Journal Article Type: Article
• Acceptance Date: Jan 6, 2021
• Online Publication Date: Jan 19, 2021
• Publication Date: Feb 7, 2021
• Deposit Date: Jan 19, 2021
• Publicly Available Date: Jan 20, 2021
• Journal: Dalton Transactions
• Print ISSN: 1477-9226
• Electronic ISSN: 1477-9234
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Issue: 5
• Pages: 1599-1603
• DOI: https://doi.org/10.1039/d0dt02626c
• Keywords: Inorganic Chemistry
• Public URL: https://hull-repository.worktribe.com/output/3697058
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2021/dt/d0dt02626c#!divAbstract