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Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Baghdadi, Neazar E.; Burke, Benjamin P.; Alresheedi, Tahani; Nigam, Shubhanchi; Saeed, Abdu; Almutairi, Farooq; Domarkas, Juozas; Khan, Abid; Archibald, Stephen J.

Authors

Neazar E. Baghdadi

Benjamin P. Burke

Tahani Alresheedi

Shubhanchi Nigam

Abdu Saeed

Farooq Almutairi

Juozas Domarkas

Abid Khan



Abstract

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

Citation

Baghdadi, N. E., Burke, B. P., Alresheedi, T., Nigam, S., Saeed, A., Almutairi, F., …Archibald, S. J. (2021). Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. Dalton transactions : an international journal of inorganic chemistry / RSoC, 50(5), 1599-1603. https://doi.org/10.1039/d0dt02626c

Journal Article Type Article
Acceptance Date Jan 6, 2021
Online Publication Date Jan 19, 2021
Publication Date Feb 7, 2021
Deposit Date Jan 19, 2021
Publicly Available Date Jan 20, 2021
Journal Dalton Transactions
Print ISSN 1477-9226
Electronic ISSN 1477-9234
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 50
Issue 5
Pages 1599-1603
DOI https://doi.org/10.1039/d0dt02626c
Keywords Inorganic Chemistry
Public URL https://hull-repository.worktribe.com/output/3697058
Publisher URL https://pubs.rsc.org/en/content/articlelanding/2021/dt/d0dt02626c#!divAbstract
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Neazar E. Baghdadi (ORCID); : Abdu Saeed (ORCID); : Stephen J. Archibald (ORCID); : Stephen J. Archibald (ResearcherID); : Single-blind; : Received 25 July 2020; Accepted 6 January 2021; Accepted Manuscript published 19 January 2021; Advance Article published 27 January 2021

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