Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Baghdadi, Neazar E.; Burke, Benjamin P.; Alresheedi, Tahani; Nigam, Shubhanchi; Saeed, Abdu; Almutairi, Farooq; Domarkas, Juozas; Khan, Abid; Archibald, Stephen J.

Abstract

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

Citation

Baghdadi, N. E., Burke, B. P., Alresheedi, T., Nigam, S., Saeed, A., Almutairi, F., Domarkas, J., Khan, A., & Archibald, S. J. (2021). Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles. Dalton Transactions : an international journal of inorganic chemistry, 50(5), 1599-1603. https://doi.org/10.1039/d0dt02626c

• Journal Article Type: Article
• Acceptance Date: Jan 6, 2021
• Online Publication Date: Jan 19, 2021
• Publication Date: Feb 7, 2021
• Deposit Date: Jan 19, 2021
• Publicly Available Date: Jan 20, 2021
• Journal: Dalton Transactions
• Print ISSN: 1477-9226
• Electronic ISSN: 1477-9234
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 50
• Issue: 5
• Pages: 1599-1603
• DOI: https://doi.org/10.1039/d0dt02626c
• Keywords: Inorganic Chemistry
• Public URL: https://hull-repository.worktribe.com/output/3697058
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2021/dt/d0dt02626c#!divAbstract