Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods

He, Ping; Burke, Benjamin P.; Clemente, Gonçalo S.; Brown, Nathan; Pamme, Nicole; Archibald, Stephen J.

Abstract

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.

Citation

He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

• Journal Article Type: Article
• Acceptance Date: Jun 9, 2016
• Online Publication Date: Jun 29, 2016
• Publication Date: Aug 1, 2016
• Deposit Date: Dec 8, 2020
• Publicly Available Date: Mar 3, 2021
• Journal: Reaction Chemistry and Engineering
• Print ISSN: 2058-9883
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Issue: 4
• Pages: 361-365
• DOI: https://doi.org/10.1039/c6re00081a
• Public URL: https://hull-repository.worktribe.com/output/987786