Skip to main content

Research Repository

Advanced Search

Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods

He, Ping; Burke, Benjamin P.; Clemente, Gonçalo S.; Brown, Nathan; Pamme, Nicole; Archibald, Stephen J.

Authors

Ping He

Benjamin P. Burke

Gonçalo S. Clemente



Abstract

The post-processing of68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified68Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.

Citation

He, P., Burke, B. P., Clemente, G. S., Brown, N., Pamme, N., & Archibald, S. J. (2016). Monolith-based68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods. Reaction Chemistry and Engineering, 1(4), 361-365. https://doi.org/10.1039/c6re00081a

Journal Article Type Article
Acceptance Date Jun 9, 2016
Online Publication Date Jun 29, 2016
Publication Date Aug 1, 2016
Deposit Date Dec 8, 2020
Publicly Available Date Mar 3, 2021
Journal Reaction Chemistry and Engineering
Print ISSN 2058-9883
Electronic ISSN 2058-9883
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 1
Issue 4
Pages 361-365
DOI https://doi.org/10.1039/c6re00081a
Public URL https://hull-repository.worktribe.com/output/987786

Files



You might also like



Downloadable Citations