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A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms

Barnes, Chris; Nair, Manoj; Aboagye, Eric O.; Archibald, Stephen J.; Allott, Louis

Authors

Chris Barnes

Manoj Nair

Eric O. Aboagye

Profile image of Louis Allott

Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics



Abstract

The automation of positron emission tomography (PET) radiochemistry using cassette-based automated radiosynthesis platforms is an essential component of clinical translation for the vast majority of 18F-based radiopharmaceuticals. The technology is widely adopted by good manufacturing practice (GMP) compliant radiopharmaceutical production facilities and research institutions developing novel tracers for clinical studies. Despite automation being fundamental to clinical translation, educational resources which introduce this branch of radiochemistry to the uninitiated are limited. Publications featuring automation assume previous experience of using these platforms and therefore, the detail they provide may not be sufficient for a novice user. In this Tutorial Account, we aim to bridge this knowledge gap and provide a resource for efficient automation for radiochemists across all levels of experience.

Citation

Barnes, C., Nair, M., Aboagye, E. O., Archibald, S. J., & Allott, L. (2022). A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms. Reaction Chemistry and Engineering, https://doi.org/10.1039/d2re00219a

Journal Article Type Article
Acceptance Date Jul 12, 2022
Online Publication Date Jul 13, 2022
Publication Date Jul 13, 2022
Deposit Date Jul 13, 2022
Publicly Available Date Oct 17, 2022
Journal Reaction Chemistry and Engineering
Print ISSN 2058-9883
Electronic ISSN 2058-9883
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1039/d2re00219a
Public URL https://hull-repository.worktribe.com/output/4029087

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