A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

Teh, Jin; Costa-Braga, Marta; Allott, Louis; Barnes, Chris; Hernandez-Gil, Javier; Tang, Mengxing; Aboagye, Eric O.; Long, Nicholas J

Abstract

The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans¬-cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.

Citation

Teh, J., Costa-Braga, M., Allott, L., Barnes, C., Hernandez-Gil, J., Tang, M., Aboagye, E. O., & Long, N. J. (2021). A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles. Chemical communications : Chem comm / the Royal Society of Chemistry, https://doi.org/10.1039/d1cc04790f

• Journal Article Type: Article
• Acceptance Date: Oct 15, 2021
• Online Publication Date: Oct 15, 2021
• Publication Date: Oct 15, 2021
• Deposit Date: Oct 18, 2021
• Publicly Available Date: Oct 18, 2021
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1039/d1cc04790f
• Keywords: Materials Chemistry; Metals and Alloys; Surfaces, Coatings and Films; General Chemistry; Ceramics and Composites; Electronic, Optical and Magnetic Materials; Catalysis
• Public URL: https://hull-repository.worktribe.com/output/3856853