Jin Teh
A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles
Teh, Jin; Costa-Braga, Marta; Allott, Louis; Barnes, Chris; Hernandez-Gil, Javier; Tang, Mengxing; Aboagye, Eric O.; Long, Nicholas J
Authors
Marta Costa-Braga
Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics
Chris Barnes
Javier Hernandez-Gil
Mengxing Tang
Eric O. Aboagye
Nicholas J Long
Abstract
The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans¬-cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.
Citation
Teh, J., Costa-Braga, M., Allott, L., Barnes, C., Hernandez-Gil, J., Tang, M., …Long, N. J. (2021). A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles. Chemical communications : Chem comm / the Royal Society of Chemistry, https://doi.org/10.1039/d1cc04790f
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 15, 2021 |
Online Publication Date | Oct 15, 2021 |
Publication Date | Oct 15, 2021 |
Deposit Date | Oct 18, 2021 |
Publicly Available Date | Oct 18, 2021 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Electronic ISSN | 1364-548X |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1039/d1cc04790f |
Keywords | Materials Chemistry; Metals and Alloys; Surfaces, Coatings and Films; General Chemistry; Ceramics and Composites; Electronic, Optical and Magnetic Materials; Catalysis |
Public URL | https://hull-repository.worktribe.com/output/3856853 |
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Publisher Licence URL
http://creativecommons.org/licenses/by/3.0
Copyright Statement
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
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