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A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles

Teh, Jin; Costa-Braga, Marta; Allott, Louis; Barnes, Chris; Hernandez-Gil, Javier; Tang, Mengxing; Aboagye, Eric O.; Long, Nicholas J

Authors

Jin Teh

Marta Costa-Braga

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Dr Louis Allott Louis.Allott@hull.ac.uk
Lecturer in Translational Radiopharmaceutics

Chris Barnes

Javier Hernandez-Gil

Mengxing Tang

Eric O. Aboagye

Nicholas J Long



Abstract

The production of 18F-labelled microbubbles (MBs) via the aluminium-[18F]fluoride ([18F]AlF) radiolabelling method and facile inverse-electron-demand Diels-Alder (IEDDA) ‘click’ chemistry is reported. An [18F]AlF-NODA-labelled tetrazine was synthesised in excellent radiochemical yield (>95% RCY) and efficiently conjugated to a trans¬-cyclooctene (TCO) functionalised phospholipid (40-50% RCY), which was incorporated into MBs (40-50% RCY). To demonstrate the potential of producing 18F-labelled MBs for clinical studies, we also describe a kit-based approach which is amenable for use in a hospital radiopharmacy setting.

Citation

Teh, J., Costa-Braga, M., Allott, L., Barnes, C., Hernandez-Gil, J., Tang, M., …Long, N. J. (2021). A kit-based aluminium-[18F]fluoride approach to radiolabelled microbubbles. Chemical communications : Chem comm / the Royal Society of Chemistry, https://doi.org/10.1039/d1cc04790f

Journal Article Type Article
Acceptance Date Oct 15, 2021
Online Publication Date Oct 15, 2021
Publication Date Oct 15, 2021
Deposit Date Oct 18, 2021
Publicly Available Date Oct 18, 2021
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1039/d1cc04790f
Keywords Materials Chemistry; Metals and Alloys; Surfaces, Coatings and Films; General Chemistry; Ceramics and Composites; Electronic, Optical and Magnetic Materials; Catalysis
Public URL https://hull-repository.worktribe.com/output/3856853

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