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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Nigam, Shubhanchi; Burke, Benjamin P.; Davies, Laura H.; Domarkas, Juozas; Wallis, Jennifer F.; Waddell, Paul G.; Waby, Jennifer S.; Benoit, David M.; Seymour, Anne Marie; Cawthorne, Christopher; Higham, Lee J.; Archibald, Stephen J.

Authors

Shubhanchi Nigam

Benjamin P. Burke

Laura H. Davies

Juozas Domarkas

Jennifer F. Wallis

Paul G. Waddell

Jennifer S. Waby

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Dr David Benoit D.Benoit@hull.ac.uk
Senior Lecturer in Molecular Physics and Astrochemistry

Anne Marie Seymour

Christopher Cawthorne

Lee J. Higham



Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Journal Article Type Article
Publication Date Jun 4, 2016
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 52
Issue 44
Pages 7114-7117
APA6 Citation Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., …Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g
DOI https://doi.org/10.1039/c5cc08325g
Keywords Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
Publisher URL http://pubs.rsc.org/en/content/articlelanding/2016/cc/c5cc08325g#!divAbstract
Copyright Statement This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Crystal Structure Data; : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0); : Single-blind; : Received 6 October 2015; Accepted 25 April 2016; Accepted Manuscript published 26 April 2016; Advance Article published 11 May 2016; Version of Record published 24 May 2016

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Copyright Statement
This work is licensed under a Creative Commons Attribution 3.0 Unported License.







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