Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Nigam, Shubhanchi; Burke, Benjamin P.; Davies, Laura H.; Domarkas, Juozas; Wallis, Jennifer F.; Waddell, Paul G.; Waby, Jennifer S.; Benoit, David M.; Seymour, Anne Marie; Cawthorne, Christopher; Higham, Lee J.; Archibald, Stephen J.

Abstract

The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.

Citation

Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., Waby, J. S., Benoit, D. M., Seymour, A. M., Cawthorne, C., Higham, L. J., & Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117. https://doi.org/10.1039/c5cc08325g

• Journal Article Type: Article
• Acceptance Date: Apr 25, 2016
• Online Publication Date: Apr 26, 2016
• Publication Date: Jun 4, 2016
• Deposit Date: Jun 28, 2018
• Publicly Available Date: Jul 12, 2018
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 52
• Issue: 44
• Pages: 7114-7117
• DOI: https://doi.org/10.1039/c5cc08325g
• Keywords: Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
• Public URL: https://hull-repository.worktribe.com/output/502540
• Publisher URL: http://pubs.rsc.org/en/content/articlelanding/2016/cc/c5cc08325g#!divAbstract
• Additional Information: : This document is Similarity Check deposited; : Supplementary Information; : Crystal Structure Data; : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0); : Single-blind; : Received 6 October 2015; Accepted 25 April 2016; Accepted Manuscript published 26 April 2016; Advance Article published 11 May 2016; Version of Record published 24 May 2016
• Contract Date: Jun 28, 2018