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Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells

Nigam, Shubhanchi; Burke, Benjamin P.; Davies, Laura H.; Domarkas, Juozas; Wallis, Jennifer F.; Waddell, Paul G.; Waby, Jennifer S.; Benoit, David M.; Seymour, Anne Marie; Cawthorne, Christopher; Higham, Lee J.; Archibald, Stephen J.


Shubhanchi Nigam

Benjamin P. Burke

Laura H. Davies

Juozas Domarkas

Jennifer F. Wallis

Paul G. Waddell

Jennifer S. Waby

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Dr David Benoit
Senior Lecturer in Molecular Physics and Astrochemistry

Anne Marie Seymour

Christopher Cawthorne

Lee J. Higham


The structural features required for mitochondrial uptake of BODIPY-based optical imaging agents have been explored. The first derivatives of this class of dyes shown to have mitochondrial membrane potential-dependent uptake in both cancer and heart cells have been developed.


Nigam, S., Burke, B. P., Davies, L. H., Domarkas, J., Wallis, J. F., Waddell, P. G., …Archibald, S. J. (2016). Structurally optimised BODIPY derivatives for imaging of mitochondrial dysfunction in cancer and heart cells. Chemical communications : Chem comm / the Royal Society of Chemistry, 52(44), 7114-7117.

Journal Article Type Article
Acceptance Date Apr 25, 2016
Online Publication Date Apr 26, 2016
Publication Date Jun 4, 2016
Deposit Date Jun 28, 2018
Publicly Available Date Jul 12, 2018
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 52
Issue 44
Pages 7114-7117
Keywords Materials Chemistry; Electronic, Optical and Magnetic Materials; General Chemistry; Surfaces, Coatings and Films; Metals and Alloys; Ceramics and Composites; Catalysis
Public URL
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Additional Information : This document is Similarity Check deposited; : Supplementary Information; : Crystal Structure Data; : The Royal Society of Chemistry has an exclusive publication licence for this journal; OPEN ACCESS: This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0); : Single-blind; : Received 6 October 2015; Accepted 25 April 2016; Accepted Manuscript published 26 April 2016; Advance Article published 11 May 2016; Version of Record published 24 May 2016


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