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Editorial: Internal and external factors affecting polycystic ovary syndrome (2025)
Journal Article
Butler, A. E., Sathyapalan, T., Randeva, H., & Atkin, S. L. (2025). Editorial: Internal and external factors affecting polycystic ovary syndrome. Frontiers in endocrinology, 16, https://doi.org/10.3389/fendo.2025.1594718

Opening paragraph:
Polycystic ovary syndrome (PCOS) pathophysiology is modified by a multitude of internal and external factors that go far beyond the traditional stimulators and inhibitors of endocrine response and function. This Research Topic cal... Read More about Editorial: Internal and external factors affecting polycystic ovary syndrome.

Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study (2025)
Journal Article
Deshmukh, H., Newham, M., Ssemmondo, E., Pond, E., Kempegowda, P., Al-Abbood, M., Malabu, U., & Sathyapalan, T. (2025). Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study. Clinical Endocrinology, https://doi.org/10.1111/cen.15250

Introduction: Polycystic ovary syndrome (PCOS) presents complex challenges during pregnancy, affecting both maternal and neonatal health. This study aims to provide a comprehensive analysis of the demographic, social and clinical dimensions of PCOS i... Read More about Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study.

Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol (2025)
Journal Article
Wilmot, E. G., Ajjan, R. A., Cheah, Y. S., Choudhary, P., Cranston, I., Elliott, R. A., Evans, M., Iqbal, A., Kamaruddin, S., Barnard-Kelly, K., Lumb, A., Min, T., Moore, P., Narendran, P., Neupane, S., Rayman, G., Sathyapalan, T., Thabit, H., Yates, T., & Leelarathna, L. (2025). Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol. BMJ open, 15(4), Article e090154. https://doi.org/10.1136/bmjopen-2024-090154

Introduction Effective management of type 2 diabetes mellitus (T2DM) consists of lifestyle modification and therapy optimisation. While glycaemic monitoring can be used as a tool to guide these changes, this can be challenging with self-monitoring of... Read More about Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol.

Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Butler, A. E., Moin, A. S. M., Begam, H. H., Waris, S., Azeez, J. M., Sathyapalan, T., Atkin, S. L., & Brennan, E. (2025). Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 26(7), Article 3008. https://doi.org/10.3390/ijms26073008

Complement proteins are increased in polycystic ovary syndrome (PCOS), as are markers of inflammation, such as the C-reactive protein (CRP); however, both may be increased in obesity. We hypothesised that body mass index (BMI)-driven CRP would compar... Read More about Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome.

A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Niinuma, S. A., Habib, H., Takemoto, A. S. N., Das, P., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2025). A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome. Cells, 14(5), Article 377. https://doi.org/10.3390/cells14050377

Objective: Rat sarcoma (Ras) proteins, Kirsten, Harvey, and Neuroblastoma rat sarcoma viral oncogene homolog (KRAS, HRAS, and NRAS, respectively), are a family of GTPases, which are key regulators of cellular growth, differentiation, and apoptosis th... Read More about A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome.

Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models (2025)
Journal Article
Jamialahmadi, T., Looha, M. A., Jangjoo, S., Emami, N., Abdalla, M. A., Ganjali, M., Salehabadi, S., Karav, S., Sathyapalan, T., Eid, A. H., Jangjoo, A., & Sahebkar, A. (2025). Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models. Journal of Diabetes & Metabolic Disorders, 24(1), Article 54. https://doi.org/10.1007/s40200-025-01564-1

Objectives: Liver fibrosis resulting from nonalcoholic fatty liver disease (NAFLD) and metabolic disorders is highly prevalent in patients with severe obesity and poses a significant health challenge. However, there is a lack of data on the effective... Read More about Predictive performance of noninvasive factors for liver fibrosis in severe obesity: a screening based on machine learning models.

Interventions to improve the quality of life in patients living with endocrine conditions A (2025)
Thesis
Ssemmondo, E. (2025). Interventions to improve the quality of life in patients living with endocrine conditions A. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5006299

Introduction
Patients living with chronic endocrine conditions experience a burden of disease which affects their quality of life compared to healthy controls. In people living with type 1 and type 2 diabetes, this may be due to micro or macrovascul... Read More about Interventions to improve the quality of life in patients living with endocrine conditions A.

Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study (2025)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Ssemmondo, E., Barnes, D., Walker, N., Walton, C., Ryder, R. E., & Sathyapalan, T. (2025). Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study. Diabetes Care, 48(3), 437-443. https://doi.org/10.2337/dc24-1833

OBJECTIVE: This study aimed to explore the relationship between time below range (TBR), impaired awareness of hypoglycemia (IAH), and severe hypoglycemia (SH). RESEARCH DESIGN AND METHODS: This cross-sectional study analyzed data from individuals wit... Read More about Time Below Range and Its Influence on Hypoglycemia Awareness and Severe Hypoglycemia: Insights From the Association of British Clinical Diabetologists Study.

Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls (2025)
Journal Article
Butler, A. E., Nandakumar, M., Sathyapalan, T., Brennan, E., & Atkin, S. L. (2025). Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls. International Journal of Molecular Sciences, 26(1), Article 321. https://doi.org/10.3390/ijms26010321

Matrix metalloproteinases (MMPs) are M2 macrophage markers that are modulated by inflammation. A disintegrin and metalloproteinases (ADAMS) and those with thrombospondin motifs (ADAMTS) regulate the shedding of membrane-bound proteins, growth factors... Read More about Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Their Ratios in Women with Polycystic Ovary Syndrome and Healthy Controls.

Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome (2024)
Journal Article
Nandakumar, M., Das, P., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2025). Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome. Biomolecules, 15(1), Article 4. https://doi.org/10.3390/biom15010004

Objective: Polycystic ovary syndrome (PCOS) is a prevalent metabolic disorder with an increased risk for cardiovascular disease (CVD) that is enhanced by obesity. This study sought to determine whether a panel of cardiovascular risk proteins (CVRPs)... Read More about Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome.

Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies—A randomised controlled trial (2024)
Journal Article
Ssemmondo, E., Shah, N., Newham, M., Rigby, A., Buckland, R., Deshmukh, H., & Sathyapalan, T. (in press). Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies—A randomised controlled trial. Diabetes, Obesity and Metabolism, https://doi.org/10.1111/dom.16116

Aims: This pilot randomised controlled trial aimed to evaluate the effect of introducing isCGM on glycaemic control and diabetes distress in individuals with T2DM receiving non-insulin therapies. Materials and Methods: Forty adults with T2DM were ran... Read More about Effect of introduction of intermittently scanned continuous glucose monitoring on glycaemic control in individuals living with type 2 diabetes mellitus treated with non-insulin therapies—A randomised controlled trial.

The variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients (2024)
Journal Article
Kilpatrick, E. S., Kallner, A., Atkin, S. L., & Sathyapalan, T. (2024). The variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients. Annals of clinical biochemistry, https://doi.org/10.1177/00045632241305936

Background: The Sampson-NIH and Martin-Hopkins low-density lipoprotein cholesterol (LDL-C) equations are advocated as being superior to the Friedewald calculation. However, their mathematical complexity means they may have different biological and an... Read More about The variability of measured and calculated low-density lipoprotein (LDL) cholesterol in statin-treated diabetes patients.

Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR) (2024)
Journal Article
Deshmukh, H., Ssemmondo, E., Adeleke, K., Mongolu, S., Aye, M., Orme, S., Flanagan, D., Abraham, P., Higham, C., & Sathyapalan, T. (2024). Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR). Clinical Endocrinology, 101(3), 274-281. https://doi.org/10.1111/cen.15112

Objective: This study aimed to understand the effect of time to remission of acromegaly on survival in people living with acromegaly. Design, Patients and Measurement: This cross-sectional study used data from the UK Acromegaly Register. We considere... Read More about Time to first remission and survival in patients with acromegaly: Evidence from the UK Acromegaly Register Study (UKAR).

Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency-Real World Evidence (2024)
Journal Article
Nadarajah, N., Ssemmondo, E., Brooks, S., Akinyombo, R., Adeleke, K., Deshmukh, H., & Sathyapalan, T. (2024). Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency-Real World Evidence. International Journal of Endocrinology and Metabolism, 22(3), Article e147825. https://doi.org/10.5812/ijem-147825

Background: Growth hormone replacement is indicated in adults with severe growth hormone (GH) deficiency, adult growth hormone deficiency assessment (AGHDA) score of at least 11 and are receiving treatment for other pituitary hormone deficiencies. Th... Read More about Baseline Clinical Factors Associated with Cessation of Growth Hormone Therapy in Patients with Severe Growth Hormone Deficiency-Real World Evidence.

A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D (2024)
Journal Article
Nandakumar, M., Das, P., Sathyapalan, T., Butler, A. E., & Atkin, S. L. (2024). A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D. International Journal of Molecular Sciences, 25(12), Article 6330. https://doi.org/10.3390/ijms25126330

Vitamin D is proposed to have a protective effect against cardiovascular disease, though the mechanism is unclear. Vitamin D deficiency is common in polycystic ovary syndrome (PCOS), where it is strongly related to obesity, insulin resistance (IR) an... Read More about A Cross-Sectional Exploratory Study of Cardiovascular Risk Biomarkers in Non-Obese Women with and without Polycystic Ovary Syndrome: Association with Vitamin D.

Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Sathyapalan, T., Das, P., Brennan, E., & Atkin, S. L. (2024). Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome. Biomedicines, 12(6), Article 1255. https://doi.org/10.3390/biomedicines12061255

Background. Perfluorinated alkyl acids (PFAAs) are persistent organic pollutants affected by BMI and ethnicity, with contradictory reports of association with vitamin D deficiency. Methods. Twenty-nine Caucasian women with non-obese polycystic ovary... Read More about Association of Vitamin D with Perfluorinated Alkyl Acids in Women with and without Non-Obese Polycystic Ovary Syndrome.

Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers (2024)
Journal Article
Nandakumar, M., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2024). Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers. Biomedicines, 12(6), Article 1137. https://doi.org/10.3390/biomedicines12061137

Introduction: Hypoglycemia has been associated with cardiovascular events, and glucose variability has been suggested to be associated with increased cardiovascular risk. Therefore, in this study, we examined the effect on proteomic cardiovascular ri... Read More about Effect of Hypoglycemia and Rebound Hyperglycemia on Proteomic Cardiovascular Risk Biomarkers.

A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome (2024)
Journal Article
Butler, A. E., Lubbad, W., Akbar, S., Kilpatrick, E. S., Sathyapalan, T., & Atkin, S. L. (2024). A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 25(9), Article 4899. https://doi.org/10.3390/ijms25094899

Glomerular hyperfiltration (GH) has been reported to be higher in women with polycystic ovary syndrome (PCOS) and is an independent risk factor for renal function deterioration, metabolic, and cardiovascular disease. The aim of this study was to dete... Read More about A Cross-Sectional Study of Glomerular Hyperfiltration in Polycystic Ovary Syndrome.

The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials (2024)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., Atkin, S. L., & Sathyapalan, T. (2024). The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Advances in Therapy, 41, 2168-2195. https://doi.org/10.1007/s12325-024-02848-3

Introduction: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterised by insulin resistance and is a risk for type 2 diabetes mellitus (T2DM). The aim of this study was to review the... Read More about The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.