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GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS (2013)
Thesis
Kahal, H. (2013). GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4215983

Studies investigating atherothrombotic risk in women with polycystic ovary syndrome (PCOS), in particular platelet function and carotid intima-media wall thickness (cIMT), have been confounded by not adequately accounting for obesity. Liraglutide is... Read More about GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS.

A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Smithson, J. A. J., Vince, R. V., Coady, A. M., Ajjan, R., Kilpatrick, E. S., & Atkin, S. L. (2014). A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clinical Endocrinology, 80(6), 843-849. https://doi.org/10.1111/cen.12258

Background Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile. Objectiv... Read More about A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease.

Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome (2012)
Journal Article
Sathyapalan, T., Shepherd, J., Coady, A.-M., Kilpatrick, E. S., & Atkin, S. L. (2012). Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism, 97(11), 3951-3955. https://doi.org/10.1210/jc.2012-2279

Background: It has been shown that there is an increase in oxidative stress in polycystic ovary syndrome (PCOS). Statins are considered to have a pleiotropic effect other than their lipid-lowering effect. These effects may be mediated in part by redu... Read More about Atorvastatin reduces malondialdehyde concentrations in patients with polycystic ovary syndrome.

The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms (2012)
Journal Article
Kahal, H., Aye, M., Rigby, A. S., Sathyapalan, T., England, R. J. A., & Atkin, S. L. (2012). The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms. Clinical Endocrinology, 76(2), 196-200. https://doi.org/10.1111/j.1365-2265.2011.04197.x

Background With increased biochemical screening, primary hyperparathyroidism (pHPT) is often discovered incidentally whilst patients are asymptomatic. Objective To assess the impact of parathyroidectomy on neuropsychological symptoms and biochemical... Read More about The effect of parathyroidectomy on neuropsychological symptoms and biochemical parameters in patients with asymptomatic primary hyperparathyroidism: pHPT neuropsychological symptoms.

The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study (2011)
Journal Article
Sathyapalan, T., Manuchehri, A. M., Thatcher, N. J., Rigby, A. S., Chapman, T., Kilpatrick, E. S., & Atkin, S. L. (2011). The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study. Journal of Clinical Endocrinology and Metabolism, 96(5), 1442-1449. https://doi.org/10.1210/jc.2010-2255

Context: There is concern whether soy phytoestrogens may affect thyroid function. If true, soy phytoestrogens may be expected to have a greater impact in subjects with subclinical hypothyroidism. Objective: The primary aim was to determine the effect... Read More about The effect of soy phytoestrogen supplementation on thyroid status and cardiovascular risk markers in patients with subclinical hypothyroidism: A randomized, double-blind, crossover study.

Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome (2010)
Journal Article
Sathyapalan, T., Shepherd, J., Arnett, C., Coady, A.-M., Kilpatrick, E. S., & Atkin, S. L. (2010). Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clinical Chemistry, 56(11), 1696-1700. https://doi.org/10.1373/clinchem.2010.144014

BACKGROUND: It has been shown that many women with polycystic ovary syndrome (PCOS) are 25-hydroxyvitamin D (25OHD) insufficient. Both statin treatment and vitamin D supplementation have been shown to improve biochemical hyperandrogenemia, insulin re... Read More about Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome.

Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes (2010)
Journal Article
Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes. Diabetes Care, 33(9), 1948-1950. https://doi.org/10.2337/dc10-0201

OBJECTIVE - Reduction in LDL and high sensitivity (hs) C-reactive protein (CRP) are independent indicators of successful cardiovascular risk reduction with statins. This study compared the effect of equivalent LDL-lowering doses of simvastatin and at... Read More about Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes.

Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement? (2009)
Journal Article
Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement?. Diabetes, Obesity and Metabolism, 12(6), 540-544. https://doi.org/10.1111/j.1463-1326.2009.01190.x

Aim: The benefit of direct, as opposed to calculated, low density lipoprotein - cholesterol (LDL-C) measurement remains unclear. This study compared the biological variability of direct LDL in patients with type 2 diabetes (T2DM) on equivalent doses... Read More about Low density lipoprotein-cholesterol variability in patients with type 2 diabetes taking atorvastatin compared to simvastatin: Justification for direct measurement?.

Cardiovascular risk reduction in insulin resistant states (2009)
Thesis
Sathyapalan, T. (2009). Cardiovascular risk reduction in insulin resistant states. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4212907

Introduction: Insulin resistance is the hall mark of a number of pathological conditions and is thought to play a major role in the cardiovascular risk associated with them. This thesis critically evaluates two insulin resistant conditions - polycyst... Read More about Cardiovascular risk reduction in insulin resistant states.

The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study (2009)
Journal Article
Sathyapalan, T., Kilpatrick, E. S., Coady, A. M., & Atkin, S. L. (2009). The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study. Journal of Clinical Endocrinology and Metabolism, 94(1), 103-108. https://doi.org/10.1210/jc.2008-1750

CONTEXT: Polycystic ovary syndrome (PCOS) is associated with increased risk of cardiovascular morbidity, whereas statins are proven to reduce cardiovascular mortality and morbidity through lipid-lowering and perhaps through their pleiotropic effects.... Read More about The effect of atorvastatin in patients with polycystic ovary syndrome: a randomized double-blind placebo-controlled study.