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Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes

Sathyapalan, Thozhukat; Atkin, Stephen L.; Kilpatrick, Eric S.

Authors

Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk

Stephen L. Atkin

Eric S. Kilpatrick



Abstract

OBJECTIVE - Reduction in LDL and high sensitivity (hs) C-reactive protein (CRP) are independent indicators of successful cardiovascular risk reduction with statins. This study compared the effect of equivalent LDL-lowering doses of simvastatin and atorvastatin on hsCRP in type 2 diabetic patients. RESEARCH DESIGN AND METHODS - A crossover study of 26 patients with type 2 diabetes taking either 40 mg simvastatin or 10 mg atorvastatin was undertaken. After 3 months on one statin, lipids and hsCRP were measured on 10 occasions over a 5-week period. The same procedure was then followed taking the other statin. RESULTS - LDL was comparable on either treatment: atorvastatin 2.2 +/- 0.2 vs. 2.1 +/- 0.3 mmol/l (mean +/- SD; P = 0.19). CRP of individuals taking atorvastatin was significantly lower than when they were taking simvastatin (median 1.08 vs. 1.47 mg/l, P = 0.0002) and was less variable (median SD of logCRP 0.0036 vs. 0.178, P = 0.0001). CONCLUSIONS - Compared with simvastatin, atorvastatin reduced hsCRP and its variability in type 2 diabetic patients. This enhanced anti-inflammatory effect may prove beneficial if lower CRP is associated with improved cardiovascular risk.

Journal Article Type Article
Publication Date Sep 1, 2010
Journal DIABETES CARE
Print ISSN 0149-5992
Electronic ISSN 1935-5548
Publisher American Diabetes Association
Peer Reviewed Peer Reviewed
Volume 33
Issue 9
Pages 1948-1950
APA6 Citation Sathyapalan, T., Atkin, S. L., & Kilpatrick, E. S. (2010). Disparate effects of atorvastatin compared with simvastatin on C-reactive protein concentrations in patients with Type 2 diabetes. Diabetes Care, 33(9), 1948-1950. doi:10.2337/dc10-0201
DOI https://doi.org/10.2337/dc10-0201
Keywords Internal Medicine; Endocrinology, Diabetes and Metabolism; Advanced and Specialised Nursing

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Copyright Statement
© 2010 by the American Diabetes Association.
Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.



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