All Outputs (34)

Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation (2022)
Thesis
Isaac, E. S. Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4508137

Atrial Fibrillation (AF) is the most common cardiac arrhythmia worldwide with sufferers of the condition facing significant morbidity and mortality. Ageing alone is identified as the most significant risk factor for developing the arrhythmia. As such... Read More about Age-Associated Changes in Voltage-Gated Sodium Channels Within the Right Atrium Predispose the Elderly to Atrial Fibrillation.

Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells (2022)
Thesis
Marsh, D. Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4224638

The order Bunyavirales represents the largest and most diverse taxonomic grouping of negative-sense RNA viruses, some of which are associated with significant diseases in humans and livestock. The global emergence of these viruses is exacerbated by t... Read More about Establishing a novel 3-dimensional microfluidic model of bunyavirus Infection to characterise exosome release from tumour cells.

Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device (2022)
Thesis
Ogidi, N. O. Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4270004

Patients with epidermal growth factor receptor (EGFR) sensitizing mutations in non small cell lung cancer (NSCLC) receive benefit from Tyrosine Kinase inhibitors. Accurate selection of patients before treatment is highly dependent on precise molecula... Read More about Determination of epithelial growth factor receptor mutations in circulatory tumour cells from non-small cell lung cancer patients isolated using a novel microfluidic device.

Synthesis and radiolabelling of ackr3 binding peptides as positron emission tomography imaging probes (2021)
Thesis
Cetin, A. (2021). Synthesis and radiolabelling of ackr3 binding peptides as positron emission tomography imaging probes. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4922422

Atypical chemokine receptor 3 (ACKR3) is an atypical chemokine receptor involved in a variety of physiological processes, including cardiac development and vascular function. The overexpression of ACKR3 is associated with metastatic progression and p... Read More about Synthesis and radiolabelling of ackr3 binding peptides as positron emission tomography imaging probes.

Investigation of the effects of anticoagulants on tissue factor mediated cellular processes (2021)
Thesis
Featherby, S. Investigation of the effects of anticoagulants on tissue factor mediated cellular processes. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223521

Thrombotic complications are common in cancer patients and are amongst the leading causes of morbidity and mortality. Recently, it was reported that treatment of cancer patients with the low molecular weight heparin (LMWH) family of anticoagulants ca... Read More about Investigation of the effects of anticoagulants on tissue factor mediated cellular processes.

Development of a dual flow microfluidic device for the study of barrier systems (2020)
Thesis
Baldwin, L. Development of a dual flow microfluidic device for the study of barrier systems. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4223404

Inflammatory Bowel Diseases (IBD) including Crohn’s Disease and Ulcerative Colitis are chronic conditions characterised by inflammation of the wall of the gastrointestinal tract. IBD has also been shown to have systemic impacts including on the centr... Read More about Development of a dual flow microfluidic device for the study of barrier systems.

An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function (2020)
Thesis
Ahmed, Y. An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function. (Thesis). Hull York Medical School, The University of Hull and The University of York. https://hull-repository.worktribe.com/output/4200904

Atherosclerosis is a major underlying cause in cardiovascular disease and a significant health concern in developed countries. Part of the mechanism by which platelets are linked to this process is via their activation by oxidised Low-Density Lipopro... Read More about An investigation into the effect of oxLDL and cyclic nucleotides on platelet cytoskeletal function.

An investigation into the regulation of cellular homeostasis through modulation of cell-surface tissue factor (2020)
Thesis
Madkhali, Y. A. An investigation into the regulation of cellular homeostasis through modulation of cell-surface tissue factor. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4836545

In recent years it has become evident that cell-derived microvesicles (MV) influence the recipient cells through inducing signalling mechanisms which lead to cell proliferation or apoptosis. In addition, the excessive release of procoagulant MV durin... Read More about An investigation into the regulation of cellular homeostasis through modulation of cell-surface tissue factor.

Platelet Actin Cytoskeletal Reversibility is Cyclic Nucleotide and Matrix Type Dependent (2019)
Thesis
Atkinson, L. (2019). Platelet Actin Cytoskeletal Reversibility is Cyclic Nucleotide and Matrix Type Dependent. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4912485

Platelets circulate in the vasculature in a quiescent state due to the presence of endothelial-derived nitric oxide (NO) and prostacyclin (PGI2). However, this inhibition is relieved upon vascular injury due to exposed matrix proteins, which cause pl... Read More about Platelet Actin Cytoskeletal Reversibility is Cyclic Nucleotide and Matrix Type Dependent.

CXCR4 and ACKR3 binding agents for imaging applications in cancer (2019)
Thesis
Renard, I. (2019). CXCR4 and ACKR3 binding agents for imaging applications in cancer. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4912463

The chemokine receptors CXCR4 and ACKR3 have been shown to be over-expressed in multiple types of cancer and are usually associated with aggressive phenotypes and poor prognosis. Successfully targeting and imaging the expression levels of these recep... Read More about CXCR4 and ACKR3 binding agents for imaging applications in cancer.

Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei (2018)
Thesis
Alshegifi, M. Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221223

Trypanosoma brucei is a medically important protozoan parasite that causes African sleeping sickness in humans. Although disease treatment is possible, it is hindered by the limited availability of effective drugs and the rapid emergence of drug resi... Read More about Identification and functional characterisation of putative mitochondrial nucleotide transporters from the human pathogen Trypanosome brucei.

Evaluation of new PET tracers for receptor tumour imaging (2018)
Thesis
Miranda, C. Evaluation of new PET tracers for receptor tumour imaging. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4193339

PET imaging can be used to non-invasively characterise biological processes at the molecular and cellular levels. The oestrogen receptor (ER) and progesterone receptor (PR) are important biomarkers in the diagnosis, prognosis and follow-up of the the... Read More about Evaluation of new PET tracers for receptor tumour imaging.

Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei (2017)
Thesis
Zheng, F. Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4221817

Trypanosoma brucei is a medically important protozoan parasite causing African sleeping sickness in humans. Treatment of this disease is possible, but is hindered by the limited availability of effective drugs as well as the rapid emergence of drug r... Read More about Identification and functional characterization of putative mitochondrial iron transporters from the human pathogen Trypanosoma brucei.

Metabolic regulation during early embryo development (2015)
Thesis
McKeegan, P. Metabolic regulation during early embryo development. (Thesis). Hull York Medical School, the University of Hull and the University of York. https://hull-repository.worktribe.com/output/4216544

The preimplantation embryo must satisfy dynamic changes in energy demand during development to the blastocyst stage. Energy is provided through regulated metabolic pathways including glycolysis, β-oxidation and oxidative phosphorylation. Oxygen consu... Read More about Metabolic regulation during early embryo development.