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The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions (2007)
Journal Article
Cockriel, D. L., McClain, J. M., Patel, K. C., Ullom, R., Hasley, T. R., Archibald, S. J., & Hubin, T. J. (2008). The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions. Inorganic Chemistry Communications, 11(1), 1-4. https://doi.org/10.1016/j.inoche.2007.10.006

The pyrazine-containing ligands 1 (pyrazine-2-carboxylic acid (pyridine-2-ylmethyl)-amide) and 2 (pyrazine-2,5-dicarboxylic acid bis[(pyridine-2-yimethyl)-amide]) have been synthesized and characterized in order to probe their ability to form polynuc... Read More about The design and synthesis of pyrazine amide ligands suitable for the "tiles" approach to molecular weaving with octahedral metal ions.

The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells (2007)
Journal Article
Pradier, A., & Ettelaie, C. (2007). The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells. Journal of vascular research, 45(1), 19-32. https://doi.org/10.1159/000109074

Background: The exposure of tissue factor (TF) at the site of injury or trauma is a rapid process that leads to the initiation of blood coagulation as well as homeostatic processes giving rise to vascular repair. Aims and Methods: By exposing human e... Read More about The influence of exogenous tissue factor on the regulators of proliferation and apoptosis in endothelial cells.

Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination (2007)
Journal Article
Zimmermann, V. S., Casati, A., Schiering, C., Caserta, S., Hess Michelini, R., Basso, V., & Mondino, A. (2007). Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination. Journal of Immunology, 179(5), 2899-2909. https://doi.org/10.4049/jimmunol.179.5.2899

Dendritic cells loaded with tumor-derived peptides induce protective CTL responses and are under evaluation in clinical trails. We report in this study that prophylactic administration of dendritic cells loaded with a MHC class II-restricted peptide... Read More about Tumors hamper the immunogenic competence of CD4+T cell-directed dendritic cell vaccination.

Mannose receptor regulation of macrophage cell migration (2007)
Journal Article
Sturge, J., Todd, S. K., Kogianni, G., McCarthy, A., & Isacke, C. M. (2007). Mannose receptor regulation of macrophage cell migration. Journal of Leukocyte Biology, 82(3), 585-593. https://doi.org/10.1189/jlb.0107053

The migration of macrophages through peripheral tissues is an essential step in the host response to infection, inflammation, and ischemia as well as in tumor progression and tissue repair. The mannose receptor (MR; CD206, previously known as the mac... Read More about Mannose receptor regulation of macrophage cell migration.

Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty (2007)
Journal Article
Ray, B., Chetter, I. C., Lee, H. L. D., Ettelaie, C., & McCollum, P. T. (2007). Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty. British journal of surgery, 94(9), 1092-1095. https://doi.org/10.1002/bjs.5759

Background:In vitro studies suggest an association between raised levels of tissue factor and restenosis after coronary percutaneous transluminal angioplasty (PTA). This prospective, controlled study examined the association between plasma tissue fac... Read More about Plasma tissue factor is a predictor for restenosis after femoropopliteal angioplasty.

Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells (2007)
Journal Article
Vart, R. J., Nikitenko, L. L., Lagos, D., Trotter, M. W., Cannon, M., Bourboulia, D., Gratrix, F., Takeuchi, Y., & Boshoff, C. (2007). Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells. Cancer Research, 67(9), 4042-4051. https://doi.org/10.1158/0008-5472.CAN-06-3321

Kaposi's sarcoma (KS) is caused by Kaposi's sarcoma-associated herpesvirus (KSHV) and consists of proliferating spindle cells, which are related to lymphatic endothelial cells (LEC). Angiopoietin-2 (Ang2) is a secreted proangiogenic and lymphangiogen... Read More about Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.

Memories are made of this: synergy of T cell receptor and cytokine signals in CD4+ central memory cell survival (2007)
Journal Article
Caserta, S., & Zamoyska, R. (2007). Memories are made of this: synergy of T cell receptor and cytokine signals in CD4+ central memory cell survival. Trends in immunology, 28(6), 245-248. https://doi.org/10.1016/j.it.2007.04.006

The ability of the immune system to 'remember' a previous encounter with antigen is the hallmark of the adaptive immune response. The signals required for CD4 + memory T cell survival are not well understood, and a recent paper lends new biochemical... Read More about Memories are made of this: synergy of T cell receptor and cytokine signals in CD4+ central memory cell survival.

Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4 (2007)
Journal Article
Ramachandran, R., Sadofsky, L., Xiao, Y., Botham, A., Cowen, M., Morice, A., & Compton, S. J. (2007). Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. American journal of physiology. Lung cellular and molecular physiology, 292(3), L788-L798. https://doi.org/10.1152/ajplung.00226.2006

Human lung fibroblasts express proteinase-activated receptor-1 (PAR 1 ), PAR 2 and PAR 3 , but not PAR 4 . Because PAR 2 has inflammatory effects on human primary bronchial fibroblasts (HPBF), we asked 1) whether the inflammatory mediators TNF-α and... Read More about Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.

Endothelial cells and cancer (2006)
Book Chapter
Nikitenko, L., & Boshoff, C. (2006). Endothelial cells and cancer. In S. Moncada, & A. Higgs (Eds.), The Vascular Endothelium II (307-334). Springer Verlag. https://doi.org/10.1007/3-540-36028-X_10

Endothelial cells play a key role in the development and function of blood and lymph vessels. Excessive proliferation and transformation of endothelial cells lead to pathological angiogenesis/ lymphangiogenesis or vascular malfunctions which are hall... Read More about Endothelial cells and cancer.

Differential functions of tissue factor in the trans-activation of cellular signalling pathways (2006)
Journal Article
Ettelaie, C., Li, C., Collier, M. E. W., Pradier, A., Frentzou, G. A., Wood, C. G., Chetter, I. C., McCollum, P. T., Bruckdorfer, K. R., & James, N. J. (2007). Differential functions of tissue factor in the trans-activation of cellular signalling pathways. Atherosclerosis, 194(1), 88-101. https://doi.org/10.1016/j.atherosclerosis.2006.10.010

In this study we examined the ability of tissue factor (TF) alone, or in conjunction with factor VIIa, factor Xa and TFPI in activating a number of key signalling pathways associated with cellular growth, stress and differentiation responses in human... Read More about Differential functions of tissue factor in the trans-activation of cellular signalling pathways.

Development of a GC-MS Method for the Simultaneous Analysis of Latent Fingerprint Components (2006)
Journal Article
Croxton, R. S., Baron, M. G., Butler, D., Kent, T., & Sears, V. G. (2006). Development of a GC-MS Method for the Simultaneous Analysis of Latent Fingerprint Components. Journal of Forensic Sciences, 51(6), 1329-1333. https://doi.org/10.1111/j.1556-4029.2006.00203.x

Latent fingerprint residue is a complex mixture of organic and inorganic compounds. A full understanding of the composition of this mixture and how it changes after deposition is lacking. Three solvent systems were compared for the simultaneous extrac... Read More about Development of a GC-MS Method for the Simultaneous Analysis of Latent Fingerprint Components.

Endo180 (2006)
Digital Artefact
Wienke, D., Sturge, J., Pirinen, N. J., Henry, L. A., Davies, G. C., & Isacke, C. M. Endo180

Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly (2006)
Journal Article
Sturge, J., Wienke, D., & Isacke, C. M. (2006). Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly. Journal of Cell Biology, 175(2), 337-347. https://doi.org/10.1083/jcb.200602125

The regulated assembly and disassembly of focal adhesions and adherens junctions contributes to cell motility and tumor invasion. Pivotal in this process is phosphorylation of myosin light chain-2 (MLC2) by Rho kinase (ROCK) downstream of Rho activat... Read More about Endosomes generate localized Rho-ROCK-MLC2-based contractile signals via Endo 180 to promote adhesion disassembly.

Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density (2006)
Journal Article
Nikitenko, L. L., Cross, T., Campo, L., Turley, H., Leek, R., Manek, S., Bicknell, R., & Rees, M. C. (2006). Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density. Clinical cancer research : an official journal of the American Association for Cancer Research, 12(19), 5648-5658. https://doi.org/10.1158/1078-0432.CCR-06-0852

Purpose: The role for the hypoxia-inducible angiogenic factor adrenomedullin (AM) in tumor growth and progression has been suggested. Calcitonin receptor - like receptor (CL) is a G protein - coupled receptor (GPCR) that mediates effects of AM, but l... Read More about Expression of terminally glycosylated calcitonin receptor - Like receptor in uterine leiomyoma: Endothelial phenotype and association with microvascular density.

Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism (2006)
Journal Article
Nikitenko, L. L., Blucher, N., Fox, S. B., Bicknell, R., Smith, D. M., & Rees, M. C. (2006). Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism. Journal of cell science, 119(5), 910-922. https://doi.org/10.1242/jcs.02783

Adrenomedullin (AM) and calcitonin gene-related peptide (CGRP) are related peptides with distinct pharmacological profiles. Calcitonin-receptor-like receptor (CRLR, now known as CL) can function as either an AM receptor or a CGRP receptor, when cotra... Read More about Adrenomedullin and CGRP interact with endogenous calcitonin-receptor-like receptor in endothial cells and induce its desensitisation by different mechanism.

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis (2006)
Journal Article
Jossé, L., Harley, M. E., Monteiro dos Santos Pires, I., & Hughes, D. A. (2006). Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis. Biochemical Journal, 393(1), 303-309. https://doi.org/10.1042/BJ20051238

Human DSS1 associates with BRCA2, a tumour suppressor protein required for efficient recombinational DNA repair, but the biochemical function of DSS1 is not known. Orthologues of DSS1 are found in organisms such as budding yeast and fission yeast tha... Read More about Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.

Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial (2005)
Journal Article
Alex, J., Laden, G., Cale, A. R. J., Bennett, S., Flowers, K., Madden, L., Gardiner, E., McCollum, P. T., & Griffin, S. C. (2005). Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial. Journal of thoracic and cardiovascular surgery, 130(6), 1623-1630. https://doi.org/10.1016/j.jtcvs.2005.08.018

Objective: Animal studies have shown that pretreatment with hyperbaric oxygen can induce central nervous system ischemic tolerance and also modulate the inflammatory response. We evaluated this therapy in patients undergoing cardiopulmonary bypass. M... Read More about Pretreatment with hyperbaric oxygen and its effect on neuropsychometric dysfunction and systemic inflammatory response after cardiopulmonary bypass: a prospective randomized double-blind trial.

Adrenomedullin and tumour angiogenesis (2005)
Journal Article
Nikitenko, L. L., Fox, S. B., Kehoe, S., Rees, M. C., & Bicknell, R. (2006). Adrenomedullin and tumour angiogenesis. The British Journal of Cancer, 94(1), 1-7. https://doi.org/10.1038/sj.bjc.6602832

The angiogenic activity of peptide adrenomedullin (AM) was first shown in 1998 . Since then, a number of reports have confirmed the ability of AM to induce the growth and migration of isolated vascular endothelial and smooth muscle cells in vitro and... Read More about Adrenomedullin and tumour angiogenesis.