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Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR (2022)
Journal Article
Saldanha, P. A., Bolanle, I. O., Palmer, T. M., Nikitenko, L. L., & Rivero, F. (2022). Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR. Cells, 11(15), Article 2315. https://doi.org/10.3390/cells11152315

The myosin light chain phosphatase target subunit 1 (MYPT1), encoded by the PPP1R12A gene, is a key component of the myosin light chain phosphatase (MLCP) protein complex. MYPT1 isoforms have been described as products of the cassette-type alternativ... Read More about Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR.

Assessment of mitochondrial dysfunction and implications in cardiovascular disorders (2022)
Journal Article
Li, Y., Ma, Y., Dang, Q. Y., Fan, X. R., Han, C. T., Xu, S. Z., & Li, P. Y. (2022). Assessment of mitochondrial dysfunction and implications in cardiovascular disorders. Life Sciences, 306, Article 120834. https://doi.org/10.1016/j.lfs.2022.120834

Mitochondria play a pivotal role in cellular function, not only acting as the powerhouse of the cell, but also regulating ATP synthesis, reactive oxygen species (ROS) production, intracellular Ca2+ cycling, and apoptosis. During the past decade, exte... Read More about Assessment of mitochondrial dysfunction and implications in cardiovascular disorders.

Can granulysin provide prognostic value in primary breast cancer? (2022)
Journal Article
Milovanović, J., Todorović-Raković, N., Vujasinović, T., Greenman, J., Mandušić, V., & Radulovic, M. (2022). Can granulysin provide prognostic value in primary breast cancer?. Pathology - Research and Practice, 237, Article 154039. https://doi.org/10.1016/j.prp.2022.154039

Background: Granulysin (GNLY) is a cytolytic and proinflammatory molecule which also acts as an immune alarmin. The multifunctional nature of this molecule has made it challenging to define its full potential as a biomarker in breast cancer. Aim: To... Read More about Can granulysin provide prognostic value in primary breast cancer?.

PRO: Biomarker surveillance for invasive fungal infections without antifungal prophylaxis could safely reduce antifungal use in acute leukaemia (2022)
Journal Article
Taynton, T., Barlow, G., & Allsup, D. (2022). PRO: Biomarker surveillance for invasive fungal infections without antifungal prophylaxis could safely reduce antifungal use in acute leukaemia. JAC-Antimicrobial Resistance, 4(4), Article dlac074. https://doi.org/10.1093/jacamr/dlac074

Mould-active antifungal prophylaxis is frequently used to prevent invasive fungal infection in patients with acute leukaemia being treated with intensive chemotherapy. Invasive fungal infections are difficult to diagnose, and despite the use of proph... Read More about PRO: Biomarker surveillance for invasive fungal infections without antifungal prophylaxis could safely reduce antifungal use in acute leukaemia.

A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms (2022)
Journal Article
Barnes, C., Nair, M., Aboagye, E. O., Archibald, S. J., & Allott, L. (2022). A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms. Reaction Chemistry and Engineering, https://doi.org/10.1039/d2re00219a

The automation of positron emission tomography (PET) radiochemistry using cassette-based automated radiosynthesis platforms is an essential component of clinical translation for the vast majority of 18F-based radiopharmaceuticals. The technology is w... Read More about A practical guide to automating fluorine-18 PET radiochemistry using commercially available cassette-based platforms.

Cellular Senescence in Acute and Chronic Wound Repair (2022)
Journal Article
Wilkinson, H. N., & Hardman, M. J. (2022). Cellular Senescence in Acute and Chronic Wound Repair. Cold Spring Harbor Perspectives in Biology, 14(11), Article a041221. https://doi.org/10.1101/cshperspect.a041221

Cellular senescence, once thought an artifact of in vitro culture or passive outcome of aging, has emerged as fundamental to tissue development and function. The senescence mechanism importantly halts cell cycle progression to protect against tumor f... Read More about Cellular Senescence in Acute and Chronic Wound Repair.

Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody (2022)
Journal Article
Greiner, J., Goetz, M., Schuler, P. J., Bulach, C., Hofmann, S., Schrezenmeier, H., …Guinn, B. A. (2022). Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody. British journal of haematology, 198(5), 866-874. https://doi.org/10.1111/bjh.18326

Nucleophosmin1 (NPM1) is one of the most commonly mutated genes in AML and is often associated with a favourable prognosis. Immune responses play an increasing role in AML treatment decisions; however, the role of immune checkpoint inhibition is stil... Read More about Enhanced stimulation of antigen-specific immune responses against nucleophosmin 1 mutated acute myeloid leukaemia by an anti-programmed death 1 antibody.

In Silico Genomic and Metabolic Atlas of Limosilactobacillus reuteri DSM 20016: An Insight into Human Health (2022)
Journal Article
Smythe, P., & Efthimiou, G. (2022). In Silico Genomic and Metabolic Atlas of Limosilactobacillus reuteri DSM 20016: An Insight into Human Health. Microorganisms, 10(7), Article 1341. https://doi.org/10.3390/microorganisms10071341

Probiotics are bacterial strains that are known to provide host health benefits. Limosilacto-bacillus reuteri is a well-documented lactic acid bacterium that has been cultured from numerous human sites. The strain investigated was L. reuteri DSM 2001... Read More about In Silico Genomic and Metabolic Atlas of Limosilactobacillus reuteri DSM 20016: An Insight into Human Health.

The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth (2022)
Journal Article
Bilton, L. J., Warren, C., Humphries, R. M., Kalsi, S., Waters, E., Francis, T., …Wade, M. A. (2022). The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth. Cancers, 14(14), Article 3491. https://doi.org/10.3390/cancers14143491

Chromobox 2 (CBX2) is a chromatin-binding component of polycomb repressive complex 1, which causes gene silencing. CBX2 expression is elevated in triple-negative breast cancer (TNBC), for which there are few therapeutic options. Here, we aimed to inv... Read More about The Epigenetic Regulatory Protein CBX2 Promotes mTORC1 Signalling and Inhibits DREAM Complex Activity to Drive Breast Cancer Cell Growth.

ATP, an attractive target for the treatment of refractory chronic cough (2022)
Journal Article
Zhang, M., Sykes, D. L., Sadofsky, L. R., & Morice, A. H. (2022). ATP, an attractive target for the treatment of refractory chronic cough. Purinergic Signalling, 18, 289-305. https://doi.org/10.1007/s11302-022-09877-z

Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common disease-modifying therapies. However, there are many patients whose cough lacks effective aetiologically targeted... Read More about ATP, an attractive target for the treatment of refractory chronic cough.

Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes (2022)
Journal Article
Fatima, I., Chen, G., Botchkareva, N. V., Sharov, A. A., Thornton, D., Wilkinson, H. N., …Botchkarev, V. A. (in press). Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes. Journal of Investigative Dermatology, https://doi.org/10.1016/j.jid.2022.04.028

Naked mole-rats (NMRs) (Heterocephalus glaber) are long-lived mammals that possess a natural resistance to cancer and other age-related pathologies, maintaining a healthy life span >30 years. In this study, using immunohistochemical and RNA-sequencin... Read More about Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes.

Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients (2022)
Journal Article
Ettelaie, C., Benelhaj, N., Featherby, S., Haque, F., Johnson, M., Cooke, J., & Maraveyas, A. (2022). Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients. Journal of Biotechnology and Biomedicine, 5(2), 78-93. https://doi.org/10.26502/jbb.2642-280050

Predicting which cancer patients are at risk of thrombosis remains a key challenge to effective thromboprophylaxis. This study was based on the hypothesis that the rapid release of TF-containing MV occurs in cancer cells that possess high levels of T... Read More about Tumour-Associated Tissue Factor (TF)-mRNA Is A Precursor for Rapid TF-Microvesicle Release and A Potential Predictive Marker for the Risk of Pulmonary Embolism (PE) in Gastrointestinal Cancer Patients.

Exploring hypoxic biology to improve radiotherapy outcomes (2022)
Journal Article
Li, C., Wiseman, L., Okoh, E., Lind, M., Roy, R., Beavis, A., & Monteiro dos Santos Pires, I. (2022). Exploring hypoxic biology to improve radiotherapy outcomes. Expert Reviews in Molecular Medicine, 24, Article E21. https://doi.org/10.1017/erm.2022.14

Ionising radiotherapy is a well-established, effective cancer treatment modality, whose efficacy has improved with the application of newer technological modalities. However, patient outcomes are governed and potentially limited by aspects of tumour... Read More about Exploring hypoxic biology to improve radiotherapy outcomes.

microRNA expression in acute myeloid leukaemia: New targets for therapy? (2022)
Journal Article
Fletcher, D., Brown, E., Javadala, J., Uysal-Onganer, P., & Guinn, B. (2022). microRNA expression in acute myeloid leukaemia: New targets for therapy?. eJHaem, 3(3), 596-608. https://doi.org/10.1002/jha2.441

Recent studies have shown that short non-coding RNAs, known as microRNAs (miRNAs) and their dysregulation, are implicated in the pathogenesis of acute myeloid leukaemia (AML). This is due to their role in the control of gene expression in a variety o... Read More about microRNA expression in acute myeloid leukaemia: New targets for therapy?.

Detection of microplastics in human lung tissue using μFTIR spectroscopy (2022)
Journal Article
Jenner, L. C., Rotchell, J. M., Bennett, R. T., Cowen, M., Tentzeris, V., & Sadofsky, L. (2022). Detection of microplastics in human lung tissue using μFTIR spectroscopy. The Science of the total environment, 831, Article 154907. https://doi.org/10.1016/j.scitotenv.2022.154907

Airborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity, especially indoors. Respiratory symptoms and disease following exposure to occupational levels of MP... Read More about Detection of microplastics in human lung tissue using μFTIR spectroscopy.