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Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant (2011)
Journal Article
Al-Balool, H. H., Weber, D., Liu, Y., Wade, M., Guleria, K., Nam, P. L. P., Clayton, J., Rowe, W., Coxhead, J., Irving, J., Elliott, D. J., Hall, A. G., Santibanez-Koref, M., & Jackson, M. S. (2011). Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Genome research, 21(11), 1788-1799. https://doi.org/10.1101/gr.116442.110

In silico analyses have established that transcripts from some genes can be processed into RNAs with rearranged exon order relative to genomic structure (post-transcriptional exon shuffling, or PTES). Although known to contribute to transcriptome div... Read More about Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant.

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis (2011)
Journal Article
Botham, A., Guo, X., Xiao, Y. P., Morice, A. H., Compton, S., & Sadofsky, L. R. (2011). Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis. Biochemical Journal, 438(2), 359-367. https://doi.org/10.1042/BJ20101958

hPAR2 (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs (proteinase-activated receptors). Previous pharmacological studies have found that activation o... Read More about Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis.

Microcrystalline identification of selected designer drugs (2011)
Journal Article
Elie, L., Baron, M., Croxton, R., & Elie, M. (2012). Microcrystalline identification of selected designer drugs. Forensic Science International, 214(1-3), 182-188. https://doi.org/10.1016/j.forsciint.2011.08.005

A microcrystalline test for the detection of 4-methylmethcathinone (mephedrone), benzylpiperazine (BZP) and 5,6-methylenedioxy-2-aminoindane (MDAI) using aqueous solutions of mercury chloride is described. Each of the compounds investigated formed sp... Read More about Microcrystalline identification of selected designer drugs.

Differential proteomics in the search for biomarkers of radiotherapy resistance (2011)
Journal Article
Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), 535-552. https://doi.org/10.1586/EPR.11.32

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where compa... Read More about Differential proteomics in the search for biomarkers of radiotherapy resistance.

Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload (2011)
Journal Article
Kim, S.-J., Choisy, S. C., Barman, P., Zhang, H., Hancox, J. C., Jones, S. A., & James, A. F. (2011). Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload. Circulation. Arrhythmia and electrophysiology, 4(5), 761-769. https://doi.org/10.1161/CIRCEP.111.964783

BACKGROUND: Although arterial hypertension and left ventricular hypertrophy are considered good epidemiological indicators of the risk of atrial fibrillation (AF) in patients, the link between elevated afterload and AF remains unclear. We investigate... Read More about Atrial remodeling and the substrate for atrial fibrillation in rat hearts with elevated afterload.

Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology (2011)
Journal Article
Van Hoeck, V., Sturmey, R. G., Bermejo-Alvarez, P., Rizos, D., Gutierrez-Adan, A., Leese, H. J., Bols, P. E. J., & Leroy, J. L. M. R. (2011). Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology. PLoS ONE, 6(8), e23183. https://doi.org/10.1371/journal.pone.0023183

Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduc... Read More about Elevated non-esterified fatty acid concentrations during bovine oocyte maturation compromise early embryo physiology.

Study of ethanol induced toxicity in liver explants using microfluidic devices. (2011)
Journal Article
Hattersley, S. M., Greenman, J., & Haswell, S. J. (2011). Study of ethanol induced toxicity in liver explants using microfluidic devices. Biomedical Microdevices, 13(6), 1005-1014. https://doi.org/10.1007/s10544-011-9570-2

Current in vitro methodologies for the culture and analysis of liver specific responses lack the sophistication of in vivo dynamics. In this work, a microfluidic based experimental methodology has been utilized to reproduce a biomimetic microenvironm... Read More about Study of ethanol induced toxicity in liver explants using microfluidic devices..

Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer (2011)
Journal Article
Pellacani, D., Packer, R. J., Frame, F. M., Oldridge, E. E., Berry, P. A., Labarthe, M.-C., Stower, M. J., Simms, M. S., Collins, A. T., & Maitland, N. J. (2011). Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer. Molecular Cancer, 10(1), Article 94. https://doi.org/10.1186/1476-4598-10-94

Background
Epigenetic control is essential for maintenance of tissue hierarchy and correct differentiation. In cancer, this hierarchical structure is altered and epigenetic control deregulated, but the relationship between these two phenomena is sti... Read More about Regulation of the stem cell marker CD133 is independent of promoter hypermethylation in human epithelial differentiation and cancer.

The cardiac sodium channel is post-translationally modified by arginine methylation (2011)
Journal Article
Beltran-Alvarez, P., Pagans, S., & Brugada, R. (2011). The cardiac sodium channel is post-translationally modified by arginine methylation. Journal of Proteome Research, 10(8), 3712-3719. https://doi.org/10.1021/pr200339n

The α subunit of the cardiac sodium channel (Na v1.5) is an essential protein in the initial depolarization phase of the cardiomyocyte action potential. Post-translational modifications such as phosphorylation are known to regulate Na v1.5 function.... Read More about The cardiac sodium channel is post-translationally modified by arginine methylation.

Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication (2011)
Journal Article
Heidel, A. J., Lawal, H. M., Felder, M., Schilde, C., Helps, N. R., Tunggal, B., Rivero, F., John, U., Schleicher, M., Eichinger, L., Platzer, M., Noegel, A. A., Schaap, P., & Glöckner, G. (2011). Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome research, 21(11), 1882-1891. https://doi.org/10.1101/gr.121137.111

Dictyostelium discoideum (DD), an extensively studied model organism for cell and developmental biology, belongs to the most derived group 4 of social amoebas, a clade of altruistic multicellular organisms. To understand genome evolution over long ti... Read More about Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication.

Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression (2011)
Journal Article
Korampalli, T. S., Green, V. L., Greenman, J., & Stafford, N. D. (2011). Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression. International Journal of Oncology, 39(4), 1033-1039. https://doi.org/10.3892/ijo.2011.1117

The expression of angiogenesis-related proteins was determined in laryngeal tumour tissue, associated tumour involved lymph nodes, apparently normal mucosa and control tissue and were related to tumour stage. Both laryngeal tumour tissue and associat... Read More about Protein profiling of angiogenesis-related growth factors in laryngeal carcinoma: Pattern of protein expression in relation to tumour progression.

The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair (2011)
Journal Article
Maybin, J. A., Battersby, S., Hirani, N., Nikitenko, L. L., Critchley, H. O., & Jabbour, H. N. (2011). The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair. Endocrinology, 152(7), 2845-2856. https://doi.org/10.1210/en.2010-1256

After menstruation, the endometrium has a remarkable capacity for repair, but the factors involved remain undefined. We hypothesize adrenomedullin (AM) plays a role in this process. Premenstrually progesterone levels decline, stimulating prostaglandi... Read More about The expression and regulation of adrenomedullin in the human endometrium: A candidate for endometrial repair.

Macrocyclic coordination chemistry (2011)
Journal Article
Archibald, S. J. (2011). Macrocyclic coordination chemistry. Annual Reports Section A :Inorganic Chemistry, 107, 274-296. https://doi.org/10.1039/c1ic90033a

This chapter reviews the literature published on macrocyclic coordination chemistry during 2010. The aim is to describe the key advances, focusing predominantly on complexes formed with transition metal and lanthanide ions. Porphyrin ligands and supr... Read More about Macrocyclic coordination chemistry.

Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α (2011)
Journal Article
Coutts, A. S., Pires, I. M., Weston, L., Buffa, F. M., Milani, M., Li, J.-L., Harris, A. L., Hammond, E. M., & La Thangue, N. B. (2011). Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α. Oncogene, 30(48), 4835-4842. https://doi.org/10.1038/onc.2011.188

Junction-mediating and regulatory protein (JMY) is a novel p53 cofactor that regulates p53 activity during stress. JMY interacts with p300/CBP, which are ubiquitous transcriptional co-activators that interact with a variety of sequence-specific trans... Read More about Hypoxia-driven cell motility reflects the interplay between JMY and HIF-1α.

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis (2011)
Journal Article
Carnell, M., Zech, T., Calaminus, S. D., Ura, S., Hagedorn, M., Johnston, S. A., May, R. C., Soldati, T., Machesky, L. M., & Insall, R. H. (2011). Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis. Journal of Cell Biology, 193(5), 831-839. https://doi.org/10.1083/jcb.201009119

WASP and SCAR homologue (WASH) is a recently identified and evolutionarily conserved regulator of actin polymerization. In this paper, we show that WASH coats mature Dictyostelium discoideum lysosomes and is essential for exocytosis of indigestible m... Read More about Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis.

Bone metastasis in prostate cancer: Emerging therapeutic strategies (2011)
Journal Article
Sturge, J., Caley, M. P., & Waxman, J. (2011). Bone metastasis in prostate cancer: Emerging therapeutic strategies. Nature Reviews Clinical Oncology, 8(6), 357-368. https://doi.org/10.1038/nrclinonc.2011.67

Metastatic bone disease (MBD) in advanced-stage cancer increases the risk of intractable bone pain, pathological skeletal fracture, spinal-cord compression and decreased survival. The disease manifestation course during MBD is largely driven by homot... Read More about Bone metastasis in prostate cancer: Emerging therapeutic strategies.