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Differential proteomics in the search for biomarkers of radiotherapy resistance

Scaife, Lucy; Hodgkinson, Victoria C.; Drew, Philip J.; Lind, Michael J.; Cawkwell, Lynn

Authors

Lucy Scaife

Victoria C. Hodgkinson

Philip J. Drew

Professor Michael Lind M.J.Lind@hull.ac.uk
Foundation Professor of Oncology/ Head of the Joint Centre for Cancer Studies

Abstract

The individualization of radiotherapy treatment would be beneficial for cancer patients; however, there are no predictive biomarkers of radiotherapy resistance in routine clinical use. This article describes the body of work in this field where comparative proteomics methods have been used for the discovery of putative biomarkers associated with radiotherapy resistance. A large number of differentially expressed proteins have been reported, mostly from the study of novel radiotherapy-resistant cell lines. Here, we have assessed these putative biomarkers through the discovery, confirmation and validation phases of the biomarker pipeline, and inform the reader on the current status of proteomics-based findings. Suggested avenues for future work are discussed.

Journal Article Type Article
Publication Date 2011-08
Journal EXPERT REVIEW OF PROTEOMICS
Print ISSN 1478-9450
Electronic ISSN 1744-8387
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 8
Issue 4
Pages 535-552
Institution Citation Scaife, L., Hodgkinson, V. C., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). Differential proteomics in the search for biomarkers of radiotherapy resistance. Expert Review of Proteomics, 8(4), (535-552). doi:10.1586/EPR.11.32. ISSN 1478-9450
DOI https://doi.org/10.1586/EPR.11.32
Keywords Antibody microarrays; Apoptosis; Biomarkers; Cell cycle; DNA repair; Mass spectrometry; Proteomics; Radioresistance; Radiotherapy
Publisher URL https://www.tandfonline.com/doi/full/10.1586/epr.11.32