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A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer

ELFadl, Dalia; Hodgkinson, Victoria C.; Long, Ervine D.; Scaife, Lucy; Drew, Philip J.; Lind, Michael J.; Cawkwell, Lynn; Lind, Michael

Authors

Dalia ELFadl

Victoria C. Hodgkinson

Ervine D. Long

Lucy Scaife

Philip J. Drew

Professor Michael Lind M.J.Lind@hull.ac.uk
Foundation Professor of Oncology/ Head of the Joint Centre for Cancer Studies

Professor Michael Lind M.J.Lind@hull.ac.uk
Foundation Professor of Oncology/ Head of the Joint Centre for Cancer Studies

Abstract

Breast conserving therapy is a currently accepted method for managing patients with early stage breast cancer. However, approximately 7% of patients may develop loco-regional tumour recurrence within 5 years. We previously reported that expression of the 26S proteasome may be associated with radio-resistance. Here we aimed to analyse the 26S proteasome in a pilot series of early breast cancers and correlate the findings with loco-regional recurrence. Fourteen patients with early breast cancer who developed loco-regional recurrence within 4 years of completing breast conserving therapy were selected according to strict criteria and compared with those from 14 patients who were disease-free at 10 years. Decreased expression of the 26S proteasome was significantly associated with radio-resistance, manifested as the development of a loco-regional recurrence within 4 years of breast conserving therapy (p = 0.018). This small pilot study provides further suggestion that the 26S proteasome may be associated with response to radiotherapy.

Journal Article Type Article
Publication Date 2011-08
Journal Breast (Edinburgh, Scotland)
Print ISSN 0960-9776
Electronic ISSN 1532-3080
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 20
Issue 4
Pages 334-337
Institution Citation ELFadl, D., Hodgkinson, V. C., Long, E. D., Scaife, L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer. The Breast : official journal of the European Society of Mastology, 20(4), 334-337. doi:10.1016/j.breast.2011.02.017
DOI https://doi.org/10.1016/j.breast.2011.02.017
Keywords 26S Proteasome; Early breast cancer; Breast conserving therapy; Immunohistochemistry; Loco-regional recurrence; Radio-resistance
Publisher URL https://www.sciencedirect.com/science/article/pii/S0960977611000531?via%3Dihub
PMID 21411324