A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer

ELFadl, Dalia; Hodgkinson, Victoria C.; Long, Ervine D.; Scaife, Lucy; Drew, Philip J.; Lind, Michael J.; Cawkwell, Lynn; Lind, Michael

Abstract

Breast conserving therapy is a currently accepted method for managing patients with early stage breast cancer. However, approximately 7% of patients may develop loco-regional tumour recurrence within 5 years. We previously reported that expression of the 26S proteasome may be associated with radio-resistance. Here we aimed to analyse the 26S proteasome in a pilot series of early breast cancers and correlate the findings with loco-regional recurrence. Fourteen patients with early breast cancer who developed loco-regional recurrence within 4 years of completing breast conserving therapy were selected according to strict criteria and compared with those from 14 patients who were disease-free at 10 years. Decreased expression of the 26S proteasome was significantly associated with radio-resistance, manifested as the development of a loco-regional recurrence within 4 years of breast conserving therapy (p = 0.018). This small pilot study provides further suggestion that the 26S proteasome may be associated with response to radiotherapy.

Citation

ELFadl, D., Hodgkinson, V. C., Long, E. D., Scaife, L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2011). A pilot study to investigate the role of the 26S proteasome in radiotherapy resistance and loco-regional recurrence following breast conserving therapy for early breast cancer. The Breast : official journal of the European Society of Mastology, 20(4), 334-337. https://doi.org/10.1016/j.breast.2011.02.017

• Journal Article Type: Article
• Acceptance Date: Feb 21, 2011
• Online Publication Date: Mar 15, 2011
• Publication Date: 2011-08
• Journal: Breast (Edinburgh, Scotland)
• Print ISSN: 0960-9776
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 20
• Issue: 4
• Pages: 334-337
• DOI: https://doi.org/10.1016/j.breast.2011.02.017
• Keywords: 26S Proteasome; Early breast cancer; Breast conserving therapy; Immunohistochemistry; Loco-regional recurrence; Radio-resistance
• Public URL: https://hull-repository.worktribe.com/output/409548
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S0960977611000531?via%3Dihub
• PMID: 21411324