Skip to main content

Research Repository

Advanced Search

All Outputs (853)

A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake (2003)
Journal Article
East, L., McCarthy, A., Wienke, D., Sturge, J., Ashworth, A., & Isacke, C. M. (2003). A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake. EMBO Reports, 4(7), 710-716. https://doi.org/10.1038/sj.embor.embor882

The four members of the mannose receptor family (the mannose receptor, the M-type phospholipase A2 receptor, DEC-205 and Endo180) share a common extracellular arrangement of an amino-terminal cysteine-rich domain followed by a fibronectin type II (FN... Read More about A targeted deletion in the endocytic receptor gene Endo 180 results in a defect in collagen uptake.

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ (2003)
Journal Article
Sawyer, C., Sturge, J., Bennett, D. C., O'Hare, M. J., Allen, W. E., Bain, J., …Vanhaesebroeck, B. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ. Cancer Research, 63(7), 1667-1675

Class IA phosphoinositide 3′-kinases (PI3Ks) regulate many cellular processes downstream of tyrosine kinases and Ras. Despite a clear implication of PI3K in cancer, little is known about the distribution of the different PI3K isoforms in malignant ce... Read More about Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-Kinase p110δ.

Adrenomedullin and the microvasculature (2002)
Journal Article
Nikitenko, L. L., Smith, D. M., Hague, S., Wilson, C. R., Bicknell, R., & Rees, M. C. (2002). Adrenomedullin and the microvasculature. Trends in Pharmacological Sciences, 23(3), 101-103. https://doi.org/10.1016/S0165-6147%2800%2901983-0

The peptide adrenomedullin shows a remarkable range of effects on the vasculature that include vasodilatation, regulation of vascular smooth muscle cell proliferation, inhibition of endothelial apoptosis and promotion of angiogenesis. It is becoming... Read More about Adrenomedullin and the microvasculature.

N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator (2002)
Journal Article
Sturge, J., Hamelin, J., & Jones, G. (2002). N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. Journal of cell science, 115(4), 699-711

Urokinase-type plasminogen activator (uPA)-uPA receptor (uPAR) and epidermal growth factor (EGF)-EGF receptor (EGFR) expression is highly correlated with breast cancer metastasis. Phosphoinositide 3-kinase (PI3K), small Rho GTPases, such as Cdc42 and... Read More about N-WASP activation by a β1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator.

Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication (2001)
Journal Article
Abidia, A., Kuhan, G., Laden, G., Bahia, H., Chetter, I., Greenman, J., & McCollum, P. (2001). Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication. Undersea and Hyperbaric Medical Society meeting abstracts, 28(32), 0 - 0

BACKGROUND: Intermittent claudication represents a minor ischaemia reperfusion episode. Exposure to hyperbaric oxygen during such episodes is a concern to many vascular surgeons because of the theoretical risk of generating excess free radicals. We a... Read More about Hyperbaric oxygen restores the antioxidant defence mechansim following exercise in patients with intermittent claudication.

Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus (2001)
Journal Article
Nikitenko, L. L., Brown, N. S., Smith, D. M., MacKenzie, I. Z., Bicknell, R., & Rees, M. C. (2001). Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus. Molecular Human Reproduction, 7(7), 655-664. https://doi.org/10.1093/molehr/7.7.655

The calcitonin receptor-like receptor (CRLR) can function as a receptor for either calcitonin gene-related peptide (CGRP) or adrenomedullin (AM), depending upon co-expression with members of a novel family of receptor activity-modifying proteins (RAM... Read More about Differential and cell-specific expression of calcitonin receptor-like receptor and receptor activity modifying proteins in the humans uterus.

Fibrin monomer and fibrinopeptide B act additively to increase DNA synthesis in smooth muscle cells cultured from human saphenous vein (2001)
Journal Article
Sturge, J., Carey, N., Davies, A. H., & Powell, J. T. (2001). Fibrin monomer and fibrinopeptide B act additively to increase DNA synthesis in smooth muscle cells cultured from human saphenous vein. Journal of vascular surgery, 33(4), 847-853. https://doi.org/10.1067/mva.2001.111984

Purpose: We investigated the hypothesis that fibrinogen increased DNA synthesis (and cell proliferation) of smooth muscle cells (SMCs) cultured from human saphenous vein and that the increased DNA synthesis was attenuated when cells were cultured on... Read More about Fibrin monomer and fibrinopeptide B act additively to increase DNA synthesis in smooth muscle cells cultured from human saphenous vein.

Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium (2000)
Journal Article
Nikitenko, L. L., MacKenzie, I. Z., Rees, M. C., & Bicknell, R. (2000). Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium. Molecular Human Reproduction, 6(9), 811-819. https://doi.org/10.1093/molehr/6.9.811

Human endometrium is a mucosa served by a microvascular blood supply that involves benign angiogenesis under the control of ovarian steroids throughout reproductive life. Adrenomedullin is a multifunctional 52-amino acid peptide involved in numerous... Read More about Adrenomedullin is an autocrine regulator of endothelial growth in human endometrium.

Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens (2000)
Journal Article
Nikitenko, L. L., Lloyd, B. H., Rudland, P. S., Fear, S., & Barraclough, R. (2000). Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens. International journal of cancer. Journal international du cancer, 86(2), 219-228. https://doi.org/10.1002/%28SICI%291097-0215%2820000415%2986%3A2%3C219%3A%3AAID-IJC11%3E3.0.CO%3B2-7

Rodent S 100A4 (p9Ka) induces a metastatic phenotype in benign rat mammary tumour cells and cooperates with the neu oncogene to produce metastatic tumours in a transgenic mouse model system. Human S 100A4 possesses similar metastasis-inducing propert... Read More about Localisation by in situ hybridisation of S100A4 (p9Ka) mRNA in primary human breast tumour specimens.

Regulation by fibrinogen and its products of intercellular adhesion molecule-1 expression in human saphenous vein endothelial cells (2000)
Journal Article
Harley, S. L., Sturge, J., & Powell, J. T. (2000). Regulation by fibrinogen and its products of intercellular adhesion molecule-1 expression in human saphenous vein endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(3), 652-658. https://doi.org/10.1161/01.ATV.20.3.652

It has been reported that fibrinogen may act as a bridging ligand, binding to intercellular adhesion molecule-1 (ICAM-1) on human umbilical vein endothelial cells and to Mac-1 on THP-1 cells (a monocytic cell line) to increase adhesion. In this study... Read More about Regulation by fibrinogen and its products of intercellular adhesion molecule-1 expression in human saphenous vein endothelial cells.

Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy (1998)
Journal Article
Nikitenko, L., Morgan, G., Kolesnikov, S. I., & Wooding, F. B. (1998). Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy. Journal of Histochemistry and Cytochemistry, 46(5), 679-688. https://doi.org/10.1177/002215549804600513

The fetus must transport considerable and increasing amounts of calcium across the placental trophoblast epithelium to support growth and development and bone formation. Active calcium transport across epithelia has been shown to correlate with calbi... Read More about Immunocytochemical and in situ hybridization studies of the distribution of calbindin D(9k) in the bovine placenta throughout pregnancy.

The effects of hypo- and hyperglycemia during lipolysis-like conditions on bovine oocyte maturation, subsequent embryo developmental and glucose metabolism
Conference Proceeding
Sturmey, R., Andries, S., Bols, P., De Bie, J., Desmet, K., Leroy, J., & Marei, W. The effects of hypo- and hyperglycemia during lipolysis-like conditions on bovine oocyte maturation, subsequent embryo developmental and glucose metabolism.

Abstract of a conference paper presented at the 31st meeting of the European Embryo Transfer Associaton, 11-12 September 2015, Ghent, Belgium.