All Outputs (956)

Postoperative remote first care for financially and environmentally sustainable healthcare (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Carradice, D., Smith, G., Chetter, I., & Yiasewmidou, M. (2025). Postoperative remote first care for financially and environmentally sustainable healthcare. npj Digital Medicine, 8, Article 299. https://doi.org/10.1038/s41746-025-01585-3

This study aims to quantify the financial and environmental savings associated with remote follow up in patients undergoing lower limb arterial surgery. A prospective observational study evaluating financial cost(fC) and environmental cost(eC) of pos... Read More about Postoperative remote first care for financially and environmentally sustainable healthcare.

Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite (2025)
Journal Article
Rezaee, S., Wright, C. E., Morice, A. H., & Rostami-Hodjegan, A. (2025). Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite. The Journal of Clinical Pharmacology, https://doi.org/10.1002/jcph.70049

To assess the antitussive effects of dextrorphan (DOR) relative to its parent compound, dextromethorphan (DEX) a double-blind, randomized, placebo-controlled crossover study was conducted in 23 healthy volunteers using citric acid cough challenge tes... Read More about Dextromethorphan versus Dextrorphan: A Quantitative Comparison of Antitussive Potency following Separate Administration of Metabolite.

Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment (2025)
Journal Article
Birring, S. S., Dicpinigaitis, P. V., Maher, T. M., Mazzone, S. B., Page, C. P., Hawi, A., Sciascia, T., & Morice, A. H. (2025). Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment. Lung, 203, Article 62. https://doi.org/10.1007/s00408-025-00812-8

Chronic cough is a significant burden on patient quality of life and is associated with poor health outcomes. Chronic cough may be a result of neural hypersensitivity due to changes in both the peripheral and the central nervous systems, although the... Read More about Kappa and Mu Opioid Receptors in Chronic Cough: Current Evidence and Future Treatment.

Classification for long-term monitoring of cough. Case Study (2025)
Journal Article
den Brinker, A. C., Rietman, R., Ouweltjes, O., van Marion, M., Thackray-Nocera, S., Crooks, M. G., & Morice, A. H. (2025). Classification for long-term monitoring of cough. Case Study. Discover Artificial Intelligence, 5, Article 56. https://doi.org/10.1007/s44163-025-00264-2

For management of chronic respiratory diseases, unobtrusive longitudinal monitoring of cough has been proposed. Such a monitoring system was developed using a classifier trained on an initial observation period. After this initial period, a personali... Read More about Classification for long-term monitoring of cough. Case Study.

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

BACKGROUND: There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective (2025)
Journal Article
Saramago, P., Gkekas, A., Arundel, C. E., Chetter, I. C., & SWHSI-2 Trial Investigators. (2025). Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective. British journal of surgery, 112(5), Article znaf077. https://doi.org/10.1093/bjs/znaf077

Background: Negative pressure wound therapy (NPWT) has been used in clinical practice for surgical wounds healing by secondary intention (SWHSI), despite limited evidence regarding its clinical effectiveness and cost-effectiveness. The aim of this st... Read More about Negative pressure wound therapy for surgical wounds healing by secondary intention is not cost-effective.

Unmet needs and future directions of treatment options for chronic cough (2025)
Journal Article
Zhang, M., & Morice, A. (2025). Unmet needs and future directions of treatment options for chronic cough. Expert Review of Respiratory Medicine, https://doi.org/10.1080/17476348.2025.2499663

Introduction: Chronic cough is a persistent condition that significantly affects patients’ quality of life and poses diagnostic and therapeutic challenges. Traditional anatomical diagnostic approaches often fail to address the underlying mechanisms,... Read More about Unmet needs and future directions of treatment options for chronic cough.

Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape (2025)
Journal Article
Molica, S., & Allsup, D. (2025). Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape. Hematological Oncology, 43(3), Article e70088. https://doi.org/10.1002/hon.70088

The fixed-duration combination of ibrutinib and venetoclax (IV) has emerged as a highly effective therapeutic strategy for treating chronic lymphocytic leukemia (CLL), marking a significant shift in the treatment paradigm for this disease. Preclinica... Read More about Fixed Duration Ibrutinib‐Venetoclax, a Redefinition of the CLL Treatment Landscape.

Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses (2025)
Journal Article
Ravindhran, B., Parovic, M., Staniland, T., Howitt, A., Nazir, S., Lathan, R., Carradice, D., Smith, G., & Chetter, I. (in press). Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses. Journal of vascular access, https://doi.org/10.1177/11297298251332043

Background:
Clinical practice guidelines endorse arteriovenous fistulae (AVF) as the preferred form of vascular access. Despite recent advancements, concerns persist regarding variable AVF patency rates. This umbrella review aimed to evaluate and sy... Read More about Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses.

Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial (2025)
Journal Article
Arundel, C., Mandefield, L., Fairhurst, C., Baird, K., Gkekas, A., Saramago, P., & Chetter, I. (in press). Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial. Lancet, https://doi.org/10.1016/S0140-6736%2825%2900143-6

Background: Surgical wound healing by secondary intention (SWHSI) presents a substantial management and financial challenge. Negative pressure wound therapy (NPWT) has increasingly been used as a treatment despite an absence of comparative evidence o... Read More about Negative pressure wound therapy versus usual care in patients with surgical wound healing by secondary intention in the UK (SWHSI-2): an open-label, multicentre, parallel-group, randomised controlled trial.

Editorial: Internal and external factors affecting polycystic ovary syndrome (2025)
Journal Article
Butler, A. E., Sathyapalan, T., Randeva, H., & Atkin, S. L. (2025). Editorial: Internal and external factors affecting polycystic ovary syndrome. Frontiers in endocrinology, 16, https://doi.org/10.3389/fendo.2025.1594718

Opening paragraph:
Polycystic ovary syndrome (PCOS) pathophysiology is modified by a multitude of internal and external factors that go far beyond the traditional stimulators and inhibitors of endocrine response and function. This Research Topic cal... Read More about Editorial: Internal and external factors affecting polycystic ovary syndrome.

Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study (2025)
Journal Article
Deshmukh, H., Newham, M., Ssemmondo, E., Pond, E., Kempegowda, P., Al-Abbood, M., Malabu, U., & Sathyapalan, T. (2025). Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study. Clinical Endocrinology, https://doi.org/10.1111/cen.15250

Introduction: Polycystic ovary syndrome (PCOS) presents complex challenges during pregnancy, affecting both maternal and neonatal health. This study aims to provide a comprehensive analysis of the demographic, social and clinical dimensions of PCOS i... Read More about Comprehensive Analysis of Psychological, Social and Clinical Aspects of Polycystic Ovary Syndrome in Pregnancy: Insights From the Born in Bradford Cohort Study.

Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol (2025)
Journal Article
Wilmot, E. G., Ajjan, R. A., Cheah, Y. S., Choudhary, P., Cranston, I., Elliott, R. A., Evans, M., Iqbal, A., Kamaruddin, S., Barnard-Kelly, K., Lumb, A., Min, T., Moore, P., Narendran, P., Neupane, S., Rayman, G., Sathyapalan, T., Thabit, H., Yates, T., & Leelarathna, L. (2025). Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol. BMJ open, 15(4), Article e090154. https://doi.org/10.1136/bmjopen-2024-090154

Introduction Effective management of type 2 diabetes mellitus (T2DM) consists of lifestyle modification and therapy optimisation. While glycaemic monitoring can be used as a tool to guide these changes, this can be challenging with self-monitoring of... Read More about Impact of real-time glucose monitoring using FreeStyle Libre 3 on glycaemia in type 2 diabetes managed with basal insulin plus SGLT2 inhibitor and/or GLP-1 agonist: the FreeDM2 randomised controlled trial protocol.

ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Sidapra, M., Lim, A., Long, J., Totty, J., Carradice, D., Smith, G., & Chetter, I. (2025). ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection. International wound journal, 22(4), Article e70234. https://doi.org/10.1111/iwj.70234

Background
Remote assessment of surgical site infection(SSI) lacks sensitivity for diagnosis of SSI but current evidence has not evaluated whether a combination of photographs and questionnaires improves diagnostic accuracy. This study aims to devel... Read More about ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection.

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Iglesias, C., Chetter, I. C., Russell, D., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.

Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Butler, A. E., Moin, A. S. M., Begam, H. H., Waris, S., Azeez, J. M., Sathyapalan, T., Atkin, S. L., & Brennan, E. (2025). Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome. International Journal of Molecular Sciences, 26(7), Article 3008. https://doi.org/10.3390/ijms26073008

Complement proteins are increased in polycystic ovary syndrome (PCOS), as are markers of inflammation, such as the C-reactive protein (CRP); however, both may be increased in obesity. We hypothesised that body mass index (BMI)-driven CRP would compar... Read More about Association of Complement Proteins with C Reactive Protein in Non-Obese Women with and Without Polycystic Ovary Syndrome.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

Introduction Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-met... Read More about Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.

A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome (2025)
Journal Article
Niinuma, S. A., Habib, H., Takemoto, A. S. N., Das, P., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2025). A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome. Cells, 14(5), Article 377. https://doi.org/10.3390/cells14050377

Objective: Rat sarcoma (Ras) proteins, Kirsten, Harvey, and Neuroblastoma rat sarcoma viral oncogene homolog (KRAS, HRAS, and NRAS, respectively), are a family of GTPases, which are key regulators of cellular growth, differentiation, and apoptosis th... Read More about A Cross-Sectional Exploratory Study of Rat Sarcoid (Ras) Activation in Women with and Without Polycystic Ovary Syndrome.

Comparative Performance Of Clinician And Computational Approaches In Forecasting Adverse Outcomes In Intermittent Claudication (2025)
Presentation / Conference Contribution
Ravindhran, B., Cutteridge, J., Pymer, S., Prosser, J., Lim, A., Hemadneh, M., Nazir, S., Mohamed, A., Lathan, R., Johnson, B. F., Smith, G., Carradice, D., & Chetter, I. C. (2025, February). Comparative Performance Of Clinician And Computational Approaches In Forecasting Adverse Outcomes In Intermittent Claudication. Presented at Vascular & Endovascular Surgery Society 49th Annual Winter Meeting, Breckenridge, Colorado

Introduction and Objectives
Machine learning (ML) based prediction modelling has demonstrated superior abilities in analysing non-linear data with complex relationships. Pilot work in this work-stream has shown that ML techniques can accurately fore... Read More about Comparative Performance Of Clinician And Computational Approaches In Forecasting Adverse Outcomes In Intermittent Claudication.

An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia (2025)
Thesis
Atkins, E. (2025). An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/5130250

Chronic limb-threatening ischaemia (CLTI) is the end-stage of peripheral arterial disease. It is associated with significant risks of limb loss and mortality, which increase with delays to revascularisation. There is currently little understanding of... Read More about An Exploration of Factors Affecting Timely Referral of Patients with Chronic Limb-Threatening Ischaemia.