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18F-FLT PET imaging of cellular proliferation in pancreatic cancer (2015)
Journal Article
Lamarca, A., Asselin, M. C., Manoharan, P., McNamara, M. G., Trigonis, I., Hubner, R., Saleem, A., & Valle, J. W. (2016). 18F-FLT PET imaging of cellular proliferation in pancreatic cancer. Critical Reviews in Oncology/Hematology, 99, 158-169. https://doi.org/10.1016/j.critrevonc.2015.12.014

Pancreatic ductal adenocarcinoma is known for its poor prognosis. Since the development of computerized tomography, magnetic resonance and endoscopic ultrasound, novel imaging techniques have struggled to get established in the management of patients... Read More about 18F-FLT PET imaging of cellular proliferation in pancreatic cancer.

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis (2015)
Journal Article
Sathyapalan, T., Atkin, S. L., David, R., & Gooderham, N. J. (2015). Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Scientific reports, 5(1), 16890-1-16890-8. https://doi.org/10.1038/srep16890

MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and m... Read More about Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis.

Sporopollenin, the least known yet toughest natural biopolymer (2015)
Journal Article
Mackenzie, G., Boa, A. N., Diego-Taboada, A., Atkin, S. L., & Sathyapalan, T. (2015). Sporopollenin, the least known yet toughest natural biopolymer. Frontiers in Materials, 2, 1-5. https://doi.org/10.3389/fmats.2015.00066

© 2015 Mackenzie, Boa, Diego-Taboada, Atkin and Sathyapalan. Sporopollenin is highly cross-linked polymer composed of carbon, hydrogen, and oxygen that is extraordinarily stable and has been found chemically intact in sedimentary rocks some 500 milli... Read More about Sporopollenin, the least known yet toughest natural biopolymer.

Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study (2015)
Journal Article
George, A., Bhatia, R. T., Buchanan, G. L., Whiteside, A., Moisey, R. S., Beer, S. F., Chattopadhyay, S., Sathyapalan, T., & John, J. (2015). Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study. PLoS ONE, 10(11), e0142045. https://doi.org/10.1371/journal.pone.0142045

Objective To investigate the prognostic effect of newly diagnosed diabetes mellitus (NDM) and impaired glucose tolerance (IGT) post myocardial infarction (MI). Research Design and Methods Retrospective cohort study of 768 patients without preexisting... Read More about Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study.

Infection in prosthetic material (2015)
Journal Article
Smith, G., & Chetter, I. (2015). Infection in prosthetic material. Surgery (Oxford), 33(11), 559-564. https://doi.org/10.1016/j.mpsur.2015.08.003

Surgical site infection (SSI) occurs when a wound created as part of a surgical procedure becomes infected. SSI is one of the most common healthcare-associated infections and occurs in approximately 5% of patients undergoing a surgical procedure. SSI... Read More about Infection in prosthetic material.

A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation (2015)
Journal Article
Barnes, R., Smith, G. E., & Chetter, I. C. (2015). A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation. The journal of vascular access, 16(5), 372-376. https://doi.org/10.5301/jva.5000401

Purpose: Arteriovenous fistula (AVF) surgery affords an excellent opportunity for junior surgeons to learn key vascular techniques. However, implementation of the European Working Time Directive has reduced trainee surgeon’s working hours, leading to... Read More about A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation.

Defining chronic cough: A systematic review of the epidemiological literature (2015)
Journal Article
Song, W. J., Chang, Y. S., Faruqi, S., Kang, M. K., Kim, J. Y., Kang, M. G., Kim, S., Jo, E. J., Lee, S. E., Kim, M. H., Plevkova, J., Park, H. W., Cho, S. H., & Morice, A. H. (2016). Defining chronic cough: A systematic review of the epidemiological literature. Allergy Asthma and Immunology Research, 8(2), 146-155. https://doi.org/10.4168/aair.2016.8.2.146

© The Korean Academy of Asthma, Allergy and Clinical Immunology. Purpose: Recent evidence suggests a global burden of chronic cough in general populations. However, the definitions vary greatly among epidemiological studies, and none have been valida... Read More about Defining chronic cough: A systematic review of the epidemiological literature.

A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication (2015)
Journal Article
Harwood, A., Cayton, T., Sarvanandan, R., Lane, R., & Chetter, I. (2016). A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication. Annals of vascular surgery, 30, 312-320. https://doi.org/10.1016/j.avsg.2015.05.043

© 2016 Elsevier Inc. All rights reserved. Background Intermittent claudication (IC) is a common condition which is associated with significant quality of life limitation. National Institute for Health and Care Excellence guidelines recommend a group-... Read More about A review of the potential local mechanisms by which exercise improves functional outcomes in intermittent claudication.

Coagulation and anticoagulation in idiopathic pulmonary fibrosis (2015)
Journal Article
Crooks, M. G., & Hart, S. P. (2015). Coagulation and anticoagulation in idiopathic pulmonary fibrosis. European Respiratory Review, 24(137), 392-399. https://doi.org/10.1183/16000617.00008414

Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events. Coagulat... Read More about Coagulation and anticoagulation in idiopathic pulmonary fibrosis.

Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable' (2015)
Journal Article
Morgan, K., Sadofsky, L. R., & Morice, A. H. (2015). Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'. Bioscience Reports, 35(5), Article e00255. https://doi.org/10.1042/BSR20150108

© 2015 Authors. Multiple mis-sense variants of TRPA1 (transient receptor potential A1) and TRPM8 (transient receptor potential M8) are recorded in the human genome single nt polymorphism (SNP) database, but their potential impact on channel signallin... Read More about Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Objective measurement of cough frequency during COPD exacerbation convalescence (2015)
Journal Article
Crooks, M. G., Hayman, Y., Innes, A., Williamson, J., Wright, C. E., & Morice, A. H. (2016). Objective measurement of cough frequency during COPD exacerbation convalescence. Lung, 194(1), 117-120. https://doi.org/10.1007/s00408-015-9782-y

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD). This study of objective co... Read More about Objective measurement of cough frequency during COPD exacerbation convalescence.

The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008 (2015)
Journal Article
Tataru, D., Jack, R. H., Lind, M. J., Møller, H., & Lüchtenborg, M. (2015). The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008. Cancer epidemiology, 39(4), 612-616. https://doi.org/10.1016/j.canep.2015.04.008

A large proportion of lung cancer patients in England are diagnosed through an emergency route, which is associated with poorer outcomes. Here, we investigated the association between emergency presentation and the odds of undergoing surgical resecti... Read More about The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008.

Over-the-counter cough medicines: New approaches (2015)
Journal Article
Morice, A. H. (2015). Over-the-counter cough medicines: New approaches. Pulmonary Pharmacology and Therapeutics, 35, 149-151. https://doi.org/10.1016/j.pupt.2015.07.006

© 2015 Elsevier Ltd. The global market for over-the-counter (OTC) medicines in the category cough/cold is enormous amounting to 5.77 billion euro in 2014 (source IMS). Despite this enormous healthcare investment, mainly by direct consumer purchase, e... Read More about Over-the-counter cough medicines: New approaches.

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial (2015)
Journal Article
Valle, J. W., Wasan, H., Lopes, A., Backen, A. C., Palmer, D. H., Morris, K., …Bridgewater, J. A. (2015). Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial. The lancet oncology, 16(8), 967-978. https://doi.org/10.1016/S1470-2045%2815%2900139-4

© 2015 Valle et al. Open Access article distributed under the terms of CC BY. Background: Cisplatin and gemcitabine is the standard first-line chemotherapy regimen for patients with advanced biliary tract cancer; expression of VEGF and its receptors... Read More about Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial.

A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis (2015)
Journal Article
Smith, G. E., Souroullos, P., Cayton, T., Harwood, A., Carradice, D., & Chetter, I. C. (2016). A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis. The journal of vascular access, 17(1), 1-5. https://doi.org/10.5301/jva.5000484

Purpose: Surgical arteriovenous fistula (AVF) or graft (AVG) is preferred to a central venous catheter for dialysis access. Surgical access may suffer thrombosis early after placement and systemic anticoagulation during surgical access formation may... Read More about A systematic review and meta-analysis of systemic intraoperative anticoagulation during arteriovenous access formation for dialysis.

Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm (2015)
Journal Article
Chetter, I., Sweeting, M., Balm, R., Desgranges, P., Ulug, P., Powell, J., & Ruptured Aneurysm Trialists. (2015). Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm. British journal of surgery, 102(10), 1229-1239. https://doi.org/10.1002/bjs.9852

BackgroundThe benefits of endovascular repair of ruptured abdominal aortic aneurysm remain controversial, without any strong evidence about advantages in specific subgroups.MethodsAn individual-patient data meta-analysis of three recent randomized tr... Read More about Individual-patient meta-analysis of three randomized trials comparing endovascular versus open repair for ruptured abdominal aortic aneurysm.

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial (2015)
Journal Article
Devereux, G., Cotton, S., Barnes, P., Briggs, A., Burns, G., Chaudhuri, R., Chrystyn, H., Davies, L., De Soyza, A., Fielding, S., Gompertz, S., Haughney, J., Lee, A. J., McCormack, K., McPherson, G., Morice, A., Norrie, J., Sullivan, A., Wilson, A., & Price, D. (2015). Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial. Trials, 16(1), Article 267. https://doi.org/10.1186/s13063-015-0782-2

© Devereux et al. Background: Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Pre... Read More about Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: Study protocol for a randomised controlled trial.