Coagulation and anticoagulation in idiopathic pulmonary fibrosis

Crooks, Michael G.; Hart, Simon P.

Abstract

Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events. Coagulation and fibrinolytic systems play central roles in wound healing and repair, processes hypothesised to be abnormal within the IPF lung. Animal models of pulmonary fibrosis have demonstrated an imbalance between thrombosis and fibrinolysis within the alveolar compartment, a finding that is also observed in IPF patients. A systemic prothrombotic state also occurs in IPF and is associated with increased mortality, but trials of anticoagulation in IPF have provided conflicting results. Differences in methodology, intervention and study populations may contribute to the inconsistent trial outcomes. The new oral anticoagulants have properties that may prove advantageous in targeting both thrombotic risk and progression of lung fibrosis.

Citation

Crooks, M. G., & Hart, S. P. (2015). Coagulation and anticoagulation in idiopathic pulmonary fibrosis. European Respiratory Review, 24(137), 392-399. https://doi.org/10.1183/16000617.00008414

• Acceptance Date: Oct 27, 2014
• Online Publication Date: Aug 31, 2015
• Publication Date: 2015-09
• Deposit Date: Mar 16, 2017
• Publicly Available Date: Mar 16, 2017
• Journal: European respiratory review
• Print ISSN: 0905-9180
• Electronic ISSN: 1600-0617
• Publisher: European Respiratory Society
• Peer Reviewed: Peer Reviewed
• Volume: 24
• Issue: 137
• Pages: 392-399
• DOI: https://doi.org/10.1183/16000617.00008414
• Keywords: Coagulation; Idiopathic pulmonary fibrosis
• Public URL: https://hull-repository.worktribe.com/output/449674
• Publisher URL: http://err.ersjournals.com/content/24/137/392
• Additional Information: This is a copy of an open access article published in European respiratory review, 2015, v.24.