Outputs (459)

Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT (2025)
Journal Article
Waldron, C.-A., Pallmann, P., Schoenbuchner, S., Harris, D., Brookes-Howell, L., Mateus, C., Bernatoniene, J., Cathie, K., Faust, S. N., Henley, J., Hinds, L., Hood, K., Huang, C., Jones, S., Kotecha, S., Milosevic, S., Nabwera, H., Patel, S., Paulus, S., Powell, C. V., …Carrol, E. D. (in press). Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT. Health Technology Assessment, 29(16), https://doi.org/10.3310/mbva3675

Background
Procalcitonin is a biomarker specific for bacterial infection, with a more rapid response than other commonly used biomarkers, such as C-reactive protein, but it is not routinely used in the National Health Service.

Objective
To deter... Read More about Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT.

Postoperative remote first care for financially and environmentally sustainable healthcare (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Carradice, D., Smith, G., Chetter, I., & Yiasewmidou, M. (2025). Postoperative remote first care for financially and environmentally sustainable healthcare. npj Digital Medicine, 8, Article 299. https://doi.org/10.1038/s41746-025-01585-3

This study aims to quantify the financial and environmental savings associated with remote follow up in patients undergoing lower limb arterial surgery. A prospective observational study evaluating financial cost(fC) and environmental cost(eC) of pos... Read More about Postoperative remote first care for financially and environmentally sustainable healthcare.

Optimising Digital Advance Care Planning Implementation in Palliative and End-of-life Care: A multi-phase mixed-methods national research programme and recommendations (2025)
Journal Article
Allsop, M. J., Birtwistle, J., Bennett, M. I., Bradshaw, A., Carder, P., Evans, C. J., Foy, R., Heavin, C., Hibbert, B., Martin, P. M., Relton, S. D., Richards, S. H., Twiddy, M., & Sleeman, K. E. (2025). Optimising Digital Advance Care Planning Implementation in Palliative and End-of-life Care: A multi-phase mixed-methods national research programme and recommendations. BMC medicine, 23, Article 291. https://doi.org/10.1186/s12916-025-04114-x

Background: Digital advance care planning (DACP) is increasingly used globally for patients with life-limiting conditions to support real-time documentation and the sharing of preferences for care. There has been low engagement with DACP systems, wit... Read More about Optimising Digital Advance Care Planning Implementation in Palliative and End-of-life Care: A multi-phase mixed-methods national research programme and recommendations.

Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial (2025)
Journal Article
Pollux, P. M., Surr, C., Cohen, J., Huang, C., Wolverson, E., Mountain, P., Clarke, R., Hawkesford-Webb, E., Winter, B., & Hudson, J. M. (2025). Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial. Pilot and Feasibility Studies, 11, Article 66. https://doi.org/10.1186/s40814-025-01637-1

Background: Many residents in care homes for older adults live with dementia. Understanding the unique profiles of cognitive impairments for each resident is important for person-centred care, yet information about specific cognitive problems is limi... Read More about Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial.

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

Background
There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses (2025)
Journal Article
Ravindhran, B., Parovic, M., Staniland, T., Howitt, A., Nazir, S., Lathan, R., Carradice, D., Smith, G., & Chetter, I. (in press). Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses. Journal of vascular access, https://doi.org/10.1177/11297298251332043

Background:
Clinical practice guidelines endorse arteriovenous fistulae (AVF) as the preferred form of vascular access. Despite recent advancements, concerns persist regarding variable AVF patency rates. This umbrella review aimed to evaluate and sy... Read More about Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses.

ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Sidapra, M., Lim, A., Long, J., Totty, J., Carradice, D., Smith, G., & Chetter, I. (2025). ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection. International wound journal, 22(4), Article e70234. https://doi.org/10.1111/iwj.70234

Background
Remote assessment of surgical site infection(SSI) lacks sensitivity for diagnosis of SSI but current evidence has not evaluated whether a combination of photographs and questionnaires improves diagnostic accuracy. This study aims to devel... Read More about ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection.

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Iglesias, C., Chetter, I. C., Russell, D., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

Introduction Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-met... Read More about Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.

A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer (2025)
Journal Article
McKigney, N., Seligmann, J., Twiddy, M., Bach, S., Mohamed, F., Fearnhead, N., Brown, J., & Harji, D. (2025). A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer. Trials, 26(1), Article 98. https://doi.org/10.1186/s13063-025-08811-z

Background: The use of interventions such as major liver and lung resection, radiofrequency ablation and transarterial chemoembolization in the management of metastatic colorectal cancer (mCRC) is now relatively commonplace in clinical practice. Howe... Read More about A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer.