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All Outputs (36)

Comprehensive evidence-based review on European antitussives (2016)
Journal Article
Morice, A., & Kardos, P. (2016). Comprehensive evidence-based review on European antitussives. BMJ Open Respiratory Research, 3(1), Article e000137. https://doi.org/10.1136/bmjresp-2016-000137

© 2016 BMJ Publishing Group. All rights reserved. Acute cough caused by viral respiratory tract infections is probably the most common illness to afflict mankind. Despite the widespread but ineffective prescribing of antibiotics, there is no specific... Read More about Comprehensive evidence-based review on European antitussives.

Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation (2016)
Journal Article
Zeybel, G. L., Pearson, J. P., Krishnan, A., Bourke, S. J., Doe, S., Anderson, A., …Ward, C. (2017). Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation. Journal of Cystic Fibrosis, 16(1), 124-131. https://doi.org/10.1016/j.jcf.2016.07.004

© 2016 The Authors Background Extra-oesophageal reflux (EOR) may lead to microaspiration in patients with cystic fibrosis (CF), a probable cause of deteriorating lung function. Successful clinical trials of ivacaftor highlight opportunities to unders... Read More about Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation.

Preoperative supervised exercise improves outcomes after elective abdominal aortic aneurysm repair (2016)
Journal Article
Barakat, H. M., Shahin, Y., Khan, J. A., McCollum, P. T., & Chetter, I. C. (2016). Preoperative supervised exercise improves outcomes after elective abdominal aortic aneurysm repair. Annals of Surgery, 264(1), 47-53. https://doi.org/10.1097/SLA.0000000000001609

Objective: The aim of the study was to assess the impact of a preoperative medically supervised exercise program on outcomes after elective abdominal aortic aneurysm (AAA) repair. Background: Functional capacity is an important predictor of postopera... Read More about Preoperative supervised exercise improves outcomes after elective abdominal aortic aneurysm repair.

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome (2016)
Journal Article
Sathyapalan, T., Dakroury, Y., Ahmed, L., Elshewehy, A. M. M., Kilpatrick, E. S., Coady, A.-M., & Atkin, S. L. (2016). Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome. Clinical Endocrinology, 85(4), 671-673. https://doi.org/10.1111/cen.13120

There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabin... Read More about Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome.

Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors (2016)
Journal Article
Dubash, S. R., Nicholas Keat, Mapelli, P., Twyman, F., Carroll, L., Kozlowski, K., …Aboagye, E. O. (2016). Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors. Journal of nuclear medicine, 57(8), 1207-1213. https://doi.org/10.2967/jnumed.115.169532

© 2016 by the Society of Nuclear Medicine and Molecular Imaging, Inc. We conducted the first-in-human study of 18F-fluoroethyl triazole [Tyr3] octreotate (18F-FET-βAG-TOCA) in patients with neuroendocrine tumors (NETs) to evaluate biodistribution, do... Read More about Clinical translation of a click-labeled 18F-octreotate radioligand for imaging neuroendocrine tumors.

A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication (2016)
Journal Article
Harwood, A., Smith, G. E., Cayton, T., Broadbent, E., & Chetter, I. C. (2016). A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication. Annals of vascular surgery, 34, 280-289. https://doi.org/10.1016/j.avsg.2016.02.009

Background Intermittent claudication (IC) is a common and debilitating symptom of peripheral arterial disease and is associated with a significant reduction in a sufferer's quality of life. Guidelines recommend a supervised exercise program (SEP) as... Read More about A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication.

Duramycin-induced calcium release in cancer cells (2016)
Journal Article
Broughton, L. J., Crow, C., Madden, L. A., & Maraveyas, A. (2016). Duramycin-induced calcium release in cancer cells. Anti-cancer drugs, 27(3), 173-182. https://doi.org/10.1097/cad.0000000000000313

Introduction: Duramycin through binding with phosphatidylethanolamine (PE) has shown potential to be an effective anti-tumour agent. However its mode of action in relation to tumour cells is not fully understood. Methods: PE expression on the surface... Read More about Duramycin-induced calcium release in cancer cells.

Extreme low-lying carotid bifurcations (2016)
Journal Article
Harwood, A. E., Leung, C. C. M., Smith, G. E., & Chetter, I. C. (2016). Extreme low-lying carotid bifurcations. Vascular Medicine, 21(4), 394-395. https://doi.org/10.1177/1358863X15627208

A 52-year-old male with no past medical history was referred to the transient ischaemic attack (TIA) clinic following an event at home. The transient symptoms were of an inability to move his left arm and leg for a period of approximately 15 minutes.... Read More about Extreme low-lying carotid bifurcations.

The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease (2016)
Journal Article
Boland, J. W., Reigada, C., Yorke, J., Hart, S. P., Bajwah, S., Ross, J., …Johnson, M. J. (2016). The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease. Journal of palliative medicine, 19(5), 549-555. https://doi.org/10.1089/jpm.2015.0355

Background: Irrreversible interstitial lung disease (ILD) is associated with high morbidity and mortality. Palliative care needs of patients and caregivers are not routinely assessed; there is no tool to identify needs and triage support in clinical... Read More about The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease.

The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes (2016)
Journal Article
Smith, G. E., Barnes, R., Chetter, I. C., Barnes, R., & Fagan, M. (2016). The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes. Annals of vascular surgery, 32, 9-14. https://doi.org/10.1016/j.avsg.2015.11.002

© 2016 Elsevier Inc. Background Arteriovenous fistulae (AVFs) are the preferred access for hemodialysis but suffer a high early failure rate. The aim of this study was to determine how venous distensibility, as measured in vitro, relates to early out... Read More about The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes.

Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression (2016)
Journal Article
Ettelaie, C., Collier, M. E. W., Featherby, S., Benelhaj, N. E., Greenman, J., & Maraveyas, A. (2016). Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression. Thrombosis journal, 14(2), Article ARTN 2. https://doi.org/10.1186/s12959-016-0075-3

Background Despite the association of cancer-derived circulating tissue factor (TF)-containing microvesicles and hypercoagulable state, correlations with the incidence of thrombosis remain unclear. Methods In this study the upregulation of TF re... Read More about Analysis of the potential of cancer cell lines to release tissue factor-containing microvesicles: correlation with tissue factor and PAR2 expression.

How does rhinovirus cause the common cold cough? (2016)
Journal Article
Atkinson, S. K., Sadofsky, L. R., & Morice, A. H. (2016). How does rhinovirus cause the common cold cough?. BMJ Open Respiratory Research, 3(1), Article e000118. https://doi.org/10.1136/bmjresp-2015-000118

© 2016, BMJ Publishing Group. All rights reserved. Cough is a protective reflex to prevent aspiration and can be triggered by a multitude of stimuli. The commonest form of cough is caused by upper respiratory tract infection and has no benefit to the... Read More about How does rhinovirus cause the common cold cough?.

Risk of recurrent venous thromboembolism and major hemorrhage in cancer-associated incidental pulmonary embolism among treated and untreated patients: a pooled analysis of 926 patients (2016)
Journal Article
Van der Hulle, T., den Exter, P. L., Planquette, B., Meyer, G., Soler, S., Monreal, M., …Klok, F. A. (2016). Risk of recurrent venous thromboembolism and major hemorrhage in cancer-associated incidental pulmonary embolism among treated and untreated patients: a pooled analysis of 926 patients. Journal of thrombosis and haemostasis : JTH, 14(1), 105-113. https://doi.org/10.1111/jth.13172

Essentials: We performed a pooled analysis of 926 patients with cancer-associated incidental pulmonary embolism (IPE). Vitamin K antagonists (VKA) are associated with a higher risk of major hemorrhage. Recurrence risk is comparable after subsegmental... Read More about Risk of recurrent venous thromboembolism and major hemorrhage in cancer-associated incidental pulmonary embolism among treated and untreated patients: a pooled analysis of 926 patients.