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High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study (2023)
Journal Article
Desai, S. R., Sivarasan, N., Johannson, K. A., George, P. M., Culver, D. A., Devaraj, A., …Inoue, Y. (in press). High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study. The lancet. Respiratory medicine, https://doi.org/10.1016/S2213-2600%2823%2900267-9

One view of sarcoidosis is that the term covers many different diseases. However, no classification framework exists for the future exploration of pathogenetic pathways, genetic or trigger predilections, patterns of lung function impairment, or treat... Read More about High-resolution CT phenotypes in pulmonary sarcoidosis: a multinational Delphi consensus study.

Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis (2023)
Journal Article
Mohamed, E., García Martínez, D. J., Hosseini, M. S., Yoong, S. Q., Fletcher, D., Hart, S., & Guinn, B. A. (2024). Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis. Carcinogenesis, 45(1-2), Article bgad091. https://doi.org/10.1093/carcin/bgad091

Lung cancer (LC) causes few symptoms in the earliest stages, leading to one of the highest mortality rates among cancers. Low-dose computerised tomography (LDCT) is used to screen high-risk individuals, reducing the mortality rate by 20%. However, LD... Read More about Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis.

Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis (2023)
Journal Article
Batten, L., Sathyapalan, T., & Palmer, T. M. (2023). Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis. International Journal of Molecular Sciences, 24(24), Article 17465. https://doi.org/10.3390/ijms242417465

This review will provide an overview of what is currently known about mechanisms linking poor glycaemic control with increased thrombotic risk. The leading causes of death in people with diabetes are strokes and cardiovascular disease. Significant mo... Read More about Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis.

Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes (2023)
Journal Article
Ravindhran, B., Lim, A. J., Kurian, T., Walshaw, J., Hitchman, L. H., Lathan, R., Smith, G. E., Carradice, D., Chetter, I. C., & Pymer, S. (in press). Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, https://doi.org/10.1016/j.ejvs.2023.11.040

Objective: This study aimed to explore the long term outcomes of patients with intermittent claudication (IC) who completed supervised exercise therapy (SET) vs. those who declined or prematurely discontinued SET, focusing on the incidence of chronic... Read More about Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes.

Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials (2023)
Journal Article
Molica, S., & Allsup, D. (2023). Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials. Expert Review of Anticancer Therapy, https://doi.org/10.1080/14737140.2023.2288899

Introduction: Chronic lymphocytic leukemia (CLL) management has witnessed a transformative shift with the advent of time-limited venetoclax and anti-CD20 monoclonal antibody (mAb) regimens, as exemplified by the groundbreaking MURANO and CLL14 trials... Read More about Fixed-duration therapy comes of age in CLL: long-term results of MURANO and CLL14 trials.

Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions (2023)
Journal Article
Molica, S., Tam, C., Allsup, D., & Polliack, A. (in press). Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions. Hematological Oncology, https://doi.org/10.1002/hon.3238

In the modern era of Chronic Lymphocytic Leukemia (CLL) targeted therapy, the loss of p53 function due to genetic abnormalities remains a significant challenge. This is because even targeted agents, which are currently the mainstay of treatment for C... Read More about Targeting TP53 disruption in chronic lymphocytic leukemia: Current strategies and future directions.

Molecular mechanisms of action of negative pressure wound therapy: A systematic review (2023)
Journal Article
Ravindhran, B., Schafer, N., Howitt, A., Carradice, D., Smith, G., & Chetter, I. (2023). Molecular mechanisms of action of negative pressure wound therapy: A systematic review. Expert Reviews in Molecular Medicine, 25, Article e29. https://doi.org/10.1017/erm.2023.24

Negative pressure wound therapy (NPWT) has significantly advanced wound care and continues to find new applications. Its effects at a molecular level however, remain a subject of debate. The aim of this systematic review is to summarize the current e... Read More about Molecular mechanisms of action of negative pressure wound therapy: A systematic review.

Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1270949. https://doi.org/10.3389/fendo.2023.1270949

Introduction: Polychlorinated biphenyls (PCBs) are organic lipophilic pollutants that accumulate in the body. Previous research has linked PCBs with menstrual function; therefore, this study was undertaken to investigate the correlation of PCBs with... Read More about Exploration of the correlation of serum polychlorinated biphenyl levels with luteal phase hormonal parameters and infertility in women with or without polycystic ovary syndrome.

High-intensity interval training in patients with intermittent claudication (2023)
Presentation / Conference Contribution
Pymer, S., Harwood, A. E., Prosser, J., Waddell, A., Rhavindhran, B., McGregor, G., Ibeggazene, S., Huang, C., Twiddy, M., Nicholls, A. R., Ingle, L., Carroll, S., He, H., Long, J., Rooms, M., & Chetter, I. C. High-intensity interval training in patients with intermittent claudication. Presented at 2022 Vascular Society of Great Britain and Ireland Annual Scientific Meeting, Brighton, UK

Objective: Provision, uptake, adherence, and completion rates for supervised exercise programs (SEP) for intermittent claudication (IC) are low. A shorter, more time-efficient, 6-week, high-intensity interval training (HIIT) program may be an effecti... Read More about High-intensity interval training in patients with intermittent claudication.

Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome (2023)
Journal Article
Brennan, E., Butler, A. E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome. Frontiers in endocrinology, 14, Article 1233484. https://doi.org/10.3389/fendo.2023.1233484

Introduction: Polychlorinated biphenyls (PCBs), organic lipophilic pollutants that accumulate through diet and increase with age, have been associated with polycystic ovary syndrome (PCOS) and shown to affect microRNA (miRNA) expression. This work ai... Read More about Serum polychlorinated biphenyl levels and circulating miRNAs in non-obese women with and without polycystic ovary syndrome.

Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit (2023)
Journal Article
Mark-Wagstaff, C., Deshmukh, H., Wilmot, E. G., Walker, N., Barnes, D., Parfitt, V., Saunders, S., Gregory, R., Choudhary, P., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2024). Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit. Diabetes, Obesity and Metabolism, 26(1), 46-53. https://doi.org/10.1111/dom.15283

Aim: Frequent hypoglycaemia results in disruption to usual hypoglycaemic autonomic responses leading to impaired awareness of hypoglycaemia, which is associated with an increased risk of severe hypoglycaemia requiring third-party assistance (SH). The... Read More about Intermittently scanned continuous glucose monitoring and hypoglycaemia awareness in drivers with diabetes: Insights from the Association of British Clinical Diabetologists Nationwide audit.

Association of polychlorinated biphenyls with vitamin D in female subjects (2023)
Journal Article
Butler, A. E., Brennan, E., Drage, D. S., Sathyapalan, T., & Atkin, S. L. (2023). Association of polychlorinated biphenyls with vitamin D in female subjects. Environmental Research, 233, Article 116465. https://doi.org/10.1016/j.envres.2023.116465

Introduction: Polychlorinated biphenyls (PCBs) are known endocrine disrupters. A potentially causal association of PCBs with vitamin D has been reported. Higher body mass index (BMI) is associated with lower PCB levels whilst the strongest associatio... Read More about Association of polychlorinated biphenyls with vitamin D in female subjects.

Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction (2023)
Journal Article
Bravington, A., Obita, G., Baddeley, E., Johnson, M., Murtagh, F., Currow, D., …Boland, J. (2023). Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction. PLoS ONE, 18(8), Article e0289501. https://doi.org/10.1371/journal.pone.0289501

Background: Malignant bowel obstruction is experienced by 15% of people with advanced cancer, preventing them from eating and drinking and causing pain, nausea and vomiting. Surgery is not always appropriate. Management options include tube or stent... Read More about Development of a Core Outcome Set for the research and assessment of malignant bowel obstruction.

Respiratory medicine (2023)
Book Chapter
Hart, S., Hearn, H., & Cookson, J. (2023). Respiratory medicine. In K. Wong, S. Walton, S. Sudhakaran, & J. Cookson (Eds.), Practical Guide to Visualizing Medicine: A Self-Assessment Manual (153-171). Springer. https://doi.org/10.1007/978-3-031-24465-0_8

This chapter covers the main presentations of respiratory disease, breathlessness, cough, sputum production, haemoptysis, wheeze and chest pain. It shows how the diagnosis can be derived from a careful history and examination and relatively simple in... Read More about Respiratory medicine.

Advancements in the Treatment of CLL: The Rise of Zanubrutinib as a Preferred Therapeutic Option (2023)
Journal Article
Molica, S., Tam, C., Allsup, D., & Polliack, A. (2023). Advancements in the Treatment of CLL: The Rise of Zanubrutinib as a Preferred Therapeutic Option. Cancers, 15(14), Article 3737. https://doi.org/10.3390/cancers15143737

Ibrutinib, the first-in-class Bruton’s tyrosine kinase inhibitor (BTKi), is a commonly deployed therapeutic option for previously untreated and relapsed/refractory (R/R) patients with chronic lymphocytic leukemia (CLL). The use of ibrutinib is, howev... Read More about Advancements in the Treatment of CLL: The Rise of Zanubrutinib as a Preferred Therapeutic Option.

An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review (2023)
Journal Article
Golpour-Hamedani, S., Pourmasoumi, M., Askari, G., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2024). An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review. Current medicinal chemistry, 31(20), 2944-2954. https://doi.org/10.2174/0929867330666230413093409

Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors... Read More about An Investigation into the Effects of Chemical, Pharmaceutical, and Herbal Compounds on Neuroglobin: A Literature Review.

Phytochemicals as substances that affect astrogliosis and their implications for the management of neurodegenerative diseases (2023)
Journal Article
Sahebkar, A., Forouzanfar, F., Pourbagher-Shahri, A. M., Vafaee, F., & Sathyapalan, T. (2024). Phytochemicals as substances that affect astrogliosis and their implications for the management of neurodegenerative diseases. Current medicinal chemistry, 31(34), 5550-5566. https://doi.org/10.2174/0929867330666230504121523

Astrocytes are a multifunctional subset of glial cells that are important in maintaining the health and function of the central nervous system (CNS). Reactive astrocytes may release inflammatory mediators, chemokines, and cytokines, as well as neurot... Read More about Phytochemicals as substances that affect astrogliosis and their implications for the management of neurodegenerative diseases.

Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial) (2023)
Journal Article
Sousa, M. S., Martin, P., Johnson, M. J., Lind, M., Maddocks, M., Bullock, A., Agar, M., Chang, S., Kochovska, S., Kinchin, I., Morgan, D., Fazekas, B., Razmovski-Naumovski, V., Lee, J. T., Itchins, M., Bray, V., & Currow, D. C. (2023). Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial). PLoS ONE, 18(5 May), Article e0285850. https://doi.org/10.1371/journal.pone.0285850

Anorexia is experienced by most people with lung cancer during the course of their disease and treatment. Anorexia reduces response to chemotherapy and the ability of patients to cope with, and complete their treatment leading to greater morbidity, p... Read More about Phase II, double blind, placebo controlled, multi-site study to evaluate the safety, feasibility and desirability of conducting a phase III study of anamorelin for anorexia in people with small cell lung cancer: A study protocol (LUANA trial).

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.