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Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis

Batten, Lucy; Sathyapalan, Thozhukat; Palmer, Timothy M.

Authors

Lucy Batten



Abstract

This review will provide an overview of what is currently known about mechanisms linking poor glycaemic control with increased thrombotic risk. The leading causes of death in people with diabetes are strokes and cardiovascular disease. Significant morbidity is associated with an increased risk of thrombosis, resulting in myocardial infarction, ischaemic stroke, and peripheral vascular disease, along with the sequelae of these events, including loss of functional ability, heart failure, and amputations. While the increased platelet activity, pro-coagulability, and endothelial dysfunction directly impact this risk, the molecular mechanisms linking poor glycaemic control with increased thrombotic risk remain unclear. This review highlights the complex mechanisms underlying thrombosis prevalence in individuals with diabetes and hyperglycaemia. Post-translational modifications, such as O-GlcNAcylation, play a crucial role in controlling protein function in diabetes. However, the role of O-GlcNAcylation remains poorly understood due to its intricate regulation and the potential involvement of multiple variables. Further research is needed to determine the precise impact of O-GlcNAcylation on specific disease processes.

Citation

Batten, L., Sathyapalan, T., & Palmer, T. M. (2023). Molecular Mechanisms Linking Diabetes with Increased Risk of Thrombosis. International Journal of Molecular Sciences, 24(24), Article 17465. https://doi.org/10.3390/ijms242417465

Journal Article Type Review
Acceptance Date Dec 10, 2023
Online Publication Date Dec 14, 2023
Publication Date Dec 1, 2023
Deposit Date Mar 1, 2024
Publicly Available Date Mar 5, 2024
Journal International Journal of Molecular Sciences
Electronic ISSN 1422-0067
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 24
Issue 24
Article Number 17465
DOI https://doi.org/10.3390/ijms242417465
Keywords Diabetes; Thrombosis; Platelet; Endothelium; Cardiovascular disease
Public URL https://hull-repository.worktribe.com/output/4496200

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0

Copyright Statement
© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).





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