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Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes. Frontiers in Molecular Biosciences, 8, Article 744459. https://doi.org/10.3389/fmolb.2021.744459

Background and Purpose: Patients with type 2 diabetes (T2D) have increased risk of cardiovascular disease (CVD), encompassing myocardial infarction, stroke, and peripheral vascular disease. We hypothesized that those biomarkers indicative of acute is... Read More about Potential Biomarkers to Predict Acute Ischemic Stroke in Type 2 Diabetes.

Chlorhexidine versus Povidone-Iodine Skin Antisepsis Prior to Upper Limb Surgery (CIPHUR): An International Multicentre Prospective Cohort Study (2021)
Journal Article
Wade, R., Bourke, G., Wormald, J., Totty, J., Stanley, G., Lewandowski, A., …The CIPHUR Collaborative. (2021). Chlorhexidine versus Povidone-Iodine Skin Antisepsis Prior to Upper Limb Surgery (CIPHUR): An International Multicentre Prospective Cohort Study. BJS Open, 5(6), Article zrab117. https://doi.org/10.1093/bjsopen/zrab117

Introduction: Surgical site infection (SSI) is the most common and costly complication of surgery. International guidelines recommend topical alcoholic chlorhexidine (CHX) prior to surgery but upper limb surgeons continue to use other antiseptics, ci... Read More about Chlorhexidine versus Povidone-Iodine Skin Antisepsis Prior to Upper Limb Surgery (CIPHUR): An International Multicentre Prospective Cohort Study.

Chronic cough: new insights and future prospects (2021)
Journal Article
Morice, A., Dicpinigaitis, P., McGarvey, L., & Birring, S. S. (2021). Chronic cough: new insights and future prospects. European Respiratory Review, 30(162), Article 210127. https://doi.org/10.1183/16000617.0127-2021

Chronic cough is defined in adults as a cough that lasts for ≥8 weeks. When it proves intractable to standard-of-care treatment, it can be referred to as refractory chronic cough (RCC). Chronic cough is now understood to be a condition of neural dysr... Read More about Chronic cough: new insights and future prospects.

Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia (2021)
Journal Article
Naylor-Adamson, L., Chacko, A., Booth, Z., Caserta, S., Jarvis, J., Khan, S., …Arman, M. (2021). Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia. Frontiers in immunology, 12, Article 766272. https://doi.org/10.3389/fimmu.2021.766272

Bacterial infections are a major cause of morbidity and mortality in chronic lymphocytic leukemia (CLL), and infection risk increases in patients treated with the Bruton’s tyrosine kinase (Btk) inhibitor, ibrutinib. Btk and related kinases (like Tec)... Read More about Bruton’s tyrosine kinase inhibitors impair FcγRIIA-driven platelet responses to bacteria in chronic lymphocytic leukemia.

Hypoglycemia-induced changes in complement pathways in type 2 diabetes (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Diboun, I., Al-Qaissi, A., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Hypoglycemia-induced changes in complement pathways in type 2 diabetes. Atherosclerosis, 46, 35-45. https://doi.org/10.1016/j.athplu.2021.11.002

Background and aims: An association between hypoglycaemia and adverse cardiovascular events has been suggested from longitudinal and retrospective cohort studies. The complement pathway proteins in hypoglycemia are not well studied. Here, we hypothes... Read More about Hypoglycemia-induced changes in complement pathways in type 2 diabetes.

Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis. Clinical Endocrinology, https://doi.org/10.1111/cen.14636

Context: Polycystic ovary syndrome (PCOS) is a heterogeneous condition affecting women of reproductive age. It is associated with dyslipidaemia and elevated plasma C-reactive protein (CRP), which increase the risks of cardiovascular disease (CVD). Ob... Read More about Effect of pharmacological interventions on lipid profiles and C-reactive protein in polycystic ovary syndrome: A systematic review and meta-analysis.

Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia (2021)
Journal Article
Moin, A. S. M., Nandakumar, M., Kahal, H., Sathyapalan, T., Atkin, S. L., & Butler, A. E. (2021). Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia. Cells, 10(11), Article 3109. https://doi.org/10.3390/cells10113109

Mild hypoglycemia is common in clinical practice. Severe hypoglycemia results in heat shock protein and associate co-chaperone changes. Whether mild prolonged hypoglycemia elic-its a similar response with inflammatory and oxidative-stress responses c... Read More about Heat shock-related protein responses and inflammatory protein changes are associated with mild prolonged hypoglycemia.

Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells (2021)
Journal Article
Adeniran, O. I., Mohammad, M. A., Featherby, S., Maraveyas, A., Boa, A. N., & Ettelaie, C. (2021). Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells. Frontiers in Bioscience-Landmark, 26(10), 752-764. https://doi.org/10.52586/4985

Introduction: The restriction of prolyl-protein cis/trans isomerase 1 (Pin1) activity has been shown to prevent the release of tissue factor (TF) leading to the accumulation of the latter protein within the cell. This study tested the ability of nove... Read More about Synthesis and analysis of small molecules to restrain the function of tissue factor within tumour cells.

Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials (2021)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (in press). Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials. Clinical Endocrinology, https://doi.org/10.1111/cen.14623

Objective: Polycystic ovary syndrome (PCOS) is a complex endocrine condition affecting women of reproductive age. It is characterized by insulin resistance and is a major risk factor for type 2 diabetes mellitus (T2DM). The objective was to review th... Read More about Impact of pharmacological interventions on insulin resistance in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials.

The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review (2021)
Journal Article
Safarzadeh, S., Shirban, F., Bagherniya, M., Sathyapalan, T., & Sahebkar, A. (2022). The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review. Phytotherapy Research, 36(1), 243-265. https://doi.org/10.1002/ptr.7308

Cancer therapy-induced oral mucositis (OM) is one of the most troublesome morbidities after radio-chemotherapy. Age, nutritional status, tumor type, oral hygiene, and treatment method are the determinants for OM incidence. In addition, oxygen-free ra... Read More about The effects of herbal medicines on cancer therapy-induced oral mucositis: A literature review.

The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease (2021)
Journal Article
Lashgari, N. A., Roudsari, N. M., Momtaz, S., Sathyapalan, T., Abdolghaffari, A. H., & Sahebkar, A. (2021). The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease. Journal of Neuroimmunology, 361, Article 577758. https://doi.org/10.1016/j.jneuroim.2021.577758

Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and oxidative stress play key etiopathological role. The pathology of PD brain is characterized by inclusions of aggregated α-synuclein (α-SYN) in the cytoplasmic region o... Read More about The involvement of JAK/STAT signaling pathway in the treatment of Parkinson's disease.

Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract (2021)
Journal Article
Korani, S., Rashidi, K., Hamelian, M., Jalalvand, A. R., Tajehmiri, A., Korani, M., …Sahebkar, A. (2021). Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract. Bioinorganic Chemistry and Applications, 2021, Article 7019130. https://doi.org/10.1155/2021/7019130

Background. Wound healing is a complex process of replacing devitalized cellular structures and tissues with healthy cells and tissue. Nanotechnology has been increasingly proposed as a novel platform to treat wounds and skin regeneration. The aim of... Read More about Evaluation of Antimicrobial and Wound Healing Effects of Gold Nanoparticles Containing Abelmoschus esculentus (L.) Aqueous Extract.

A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers (2021)
Journal Article
Hitchman, L., Totty, J., Lathan, R., Sidapra, M., Smith, G., Carradice, D., & Chetter, I. (2021). A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers. British journal of surgery, 108(supp.6), Article 1031. https://doi.org/10.1093/bjs/znab259.1127

Aim The purpose of this mixed methods feasibility study was to assess the feasibility of delivering ESWT to patients with DFUs. It also aimed to explore any potential clinical effect of ESWT on wound healing and investigate whether ESWT may offer an... Read More about A Mixed Methods Feasibility Study of Extracorporeal Shockwave Therapy for Diabetic Foot Ulcers.

Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study (2021)
Journal Article
Holmes, P., Bell, H. E., Bozkurt, K., Catarig, A. M., Clark, A., Machell, A., & Sathyapalan, T. (2021). Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study. Diabetes Therapy, https://doi.org/10.1007/s13300-021-01141-8

Introduction: Once-weekly (OW) semaglutide was associated with clinically relevant improvements in glycaemic control and body weight versus comparators in the SUSTAIN randomised controlled trials (RCTs). SURE UK, which is one of a series of individua... Read More about Real-World Use of Once-Weekly Semaglutide in Type 2 Diabetes: Results from the SURE UK Multicentre, Prospective, Observational Study.

Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit (2021)
Journal Article
Shah, N., Deshmukh, H., Wilmot, E. G., Patmore, J., Choudhary, P., Christian, P., …Sathyapalan, T. (in press). Previous structured education attendance and the relationship with HbA1c and hypoglycaemia awareness in people living with type 1 diabetes mellitus using FreeStyle Libre: insights from the Association of British Clinical Diabetologists (ABCD) Nationwide Audit. British Journal of Diabetes, https://doi.org/10.15277/bjd.2021.308

Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit (2021)
Journal Article
Deshmukh, H., Wilmot, E. G., Choudhary, P., Narendran, P., Shah, N., Barnes, D., …Sathyapalan, T. (2021). Impaired Awareness of Hypoglycemia and Severe Hypoglycemia in Drivers With Diabetes: Insights From the Association of British Clinical Diabetologists Nationwide Audit. Diabetes Care, 44(11), e190-e191. https://doi.org/10.2337/dc21-1181

Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders (2021)
Journal Article
Koushki, K., Shahbaz, S. K., Keshavarz, M., Bezsonov, E. E., Sathyapalan, T., & Sahebkar, A. (2021). Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders. Biomolecules, 11(9), Article 1289. https://doi.org/10.3390/biom11091289

Gold nanoparticles (GNPs) have been recently applied for various diagnostic and therapeutic purposes. The unique properties of these nanoparticles (NPs), such as relative ease of synthesis in various sizes, shapes and charges, stability, high drug-lo... Read More about Gold nanoparticles: Multifaceted roles in the management of autoimmune disorders.

A Systematic Review of Exercise Prescription in Patients with Intermittent Claudication: Does Pain Matter? (2021)
Journal Article
Seed, S., Harwood, A., Sinclair, J., Pymer, S., Caldow, E., Ingle, L., …Birkett, S. (in press). A Systematic Review of Exercise Prescription in Patients with Intermittent Claudication: Does Pain Matter?. Annals of vascular surgery, https://doi.org/10.1016/j.avsg.2021.06.025

Background: Current guidelines for intermittent claudication advocate exercise at moderate to maximal claudication pain. However, adherence rates to supervised exercise programmes (SEP) remain poor and claudication pain is a contributing factor. Limi... Read More about A Systematic Review of Exercise Prescription in Patients with Intermittent Claudication: Does Pain Matter?.