All Outputs (38)

Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials (2022)
Journal Article
Dawed, A. Y., Mari, A., Brown, A., McDonald, T. J., Li, L., Wang, S., …Jonsson, A. (2023). Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials. Lancet Diabetes and Endocrinology, 11(1), 33-41. https://doi.org/10.1016/S2213-8587%2822%2900340-0

Background: In the treatment of type 2 diabetes, GLP-1 receptor agonists lower blood glucose concentrations, body weight, and have cardiovascular benefits. The efficacy and side effects of GLP-1 receptor agonists vary between people. Human pharmacoge... Read More about Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials.

Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy (2022)
Journal Article
Bruce, C., Ubhi, N., McKeegan, P., & Sanders, K. (2023). Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy. The American journal of cardiology, 188, P110-P119. https://doi.org/10.1016/j.amjcard.2022.10.059

Myocardial bridging (MB) is a congenital variant in which a segment of a coronary artery follows an atypical intramural course under a “bridge” of myocardium and is notably common in hypertrophic cardiomyopathy (HCM). This systematic review and meta-... Read More about Systematic Review and Meta-Analysis of Cardiovascular Consequences of Myocardial Bridging in Hypertrophic Cardiomyopathy.

Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience (2022)
Journal Article
Ravindhran, B., Totty, J. P., Sidapra, M., Lathan, R., Carradice, D., Chetter, I. C., & Smith, G. E. (in press). Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience. The journal of vascular access, https://doi.org/10.1177/11297298221141497

Background: The reduction in distal arterial flow following arteriovenous fistula (AVF) creation can cause a perfusion deficit known as haemodialysis access induced distal ischemia (HAIDI). Various techniques have been advocated to treat this difficu... Read More about Long term outcomes of ‘Christmas Tree’ banding for haemodialysis access induced distal ischemia: A 13-year experience.

Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree (2022)
Journal Article
Curry, J., Roberts, H., Smith, A., Riley, D., Pearson, M., & Forbes, C. C. (2022). Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree. Research Involvement and Engagement, 8(1), Article 66. https://doi.org/10.1186/s40900-022-00395-1

Background: Lung cancer has one of the highest incidence and mortality rates worldwide. Physical activity can provide those diagnosed with lung cancer with several physical and psychological benefits. However, the examination of digitally delivered p... Read More about Developing and testing the ExerciseGuide UK website for people with lung cancer: reflections on the added value of patient and public involvement within a doctoral degree.

Examining the knowledge work of person-centred care: Towards epistemic reciprocity (2022)
Journal Article
Dell'Olio, M., Whybrow, P., & Reeve, J. (2023). Examining the knowledge work of person-centred care: Towards epistemic reciprocity. Patient Education and Counseling, 107, Article 107575. https://doi.org/10.1016/j.pec.2022.107575

Objective: It is increasingly recognised that when healthcare staff fails to give adequate credence to patients' illness-related knowledge work, this epistemic injustice undermines person-centred care. Therefore, we set out to examine the experiences... Read More about Examining the knowledge work of person-centred care: Towards epistemic reciprocity.

Parental death: a systematic review of support experiences and needs of children and parent survivors (2022)
Journal Article
Wray, A., Pickwell-Smith, B., Greenley, S., Pask, S., Bamidele, O., Wright, B., …Boland, J. W. (2022). Parental death: a systematic review of support experiences and needs of children and parent survivors. BMJ supportive & palliative care, https://doi.org/10.1136/spcare-2022-003793

Background: Bereaved people need a supportive response from those around them. Knowing children's and surviving parents' needs following parental death is the first step to ensuring a supportive response. However, no systematic review has reported on... Read More about Parental death: a systematic review of support experiences and needs of children and parent survivors.

The negative impact of COVID-19 on working memory revealed using a rapid online quiz (2022)
Journal Article
Baseler, H. A., Aksoy, M., Salawu, A., Green, A., & Asghar, A. U. (2022). The negative impact of COVID-19 on working memory revealed using a rapid online quiz. PLoS ONE, 17(11), Article e0269353. https://doi.org/10.1371/journal.pone.0269353

Although coronavirus disease 2019 (COVID-19) affects the respiratory system, it can also have neurological consequences leading to cognitive deficits such as memory problems. The aim of our study was to assess the impact of COVID-19 on working memory... Read More about The negative impact of COVID-19 on working memory revealed using a rapid online quiz.

Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis (2022)
Journal Article
Deshmukh, H., Akbar, S., Bhaiji, A., Saeed, Y., Shah, N., Adeleke, K., …Sathyapalan, T. (2023). Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis. Clinical Endocrinology, 98(3), 400-406. https://doi.org/10.1111/cen.14847

Introduction: Some but not all women with polycystic ovary syndrome (PCOS) develop the metabolic syndrome (MS). The objective of this study was to determine if a subset of women with PCOS had higher androgen levels predisposing them to MS and whether... Read More about Assessing the androgenic and metabolic heterogeneity in polycystic ovary syndrome using cluster analysis.

Microplastics in the surgical environment (2022)
Journal Article
Field, D. T., Green, J. L., Bennett, R., Jenner, L. C., Sadofsky, L., Chapman, E., …Rotchell, J. M. (2022). Microplastics in the surgical environment. Environment International, 170, Article 107630. https://doi.org/10.1016/j.envint.2022.107630

Atmospheric microplastics (MPs) have been consistently detected within indoor and outdoor air samples. Locations with high human activity are reported to have high MP levels. The aim was to quantify and characterise the MPs present within the surgica... Read More about Microplastics in the surgical environment.

Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials (2022)
Journal Article
Abdalla, M. A., Shah, N., Deshmukh, H., Sahebkar, A., Östlundh, L., Al-Rifai, R. H., …Sathyapalan, T. (2022). Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials. Therapeutic Advances in Endocrinology and Metabolism, 13, https://doi.org/10.1177/20420188221127142

Context: Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders affecting women of reproductive age, and metformin is a widely used medication in managing this condition. Aim: To review the available literature comprehensively o... Read More about Impact of metformin on the clinical and metabolic parameters of women with polycystic ovary syndrome: a systematic review and meta-analysis of randomised controlled trials.

Frailty Assessment in UK and Irish Vascular Centres (FAVE): A survey to investigate data collection methods and impact on clinical practice (2022)
Journal Article
Hitchman, L. H., Palmer, J., Lathan, R., Totty, J., Smith, G. E., Carradice, D., & Chetter, I. C. (in press). Frailty Assessment in UK and Irish Vascular Centres (FAVE): A survey to investigate data collection methods and impact on clinical practice. Journal of Vascular Societies Great Britain and Ireland,

UK Doctors Delivering Physical Activity Advice: What Are the Challenges and Possible Solutions? A Qualitative Study (2022)
Journal Article
Vishnubala, D., Iqbal, A., Marino, K., Whatmough, S., Barker, R., Salman, D., …Nykjaer, C. (2022). UK Doctors Delivering Physical Activity Advice: What Are the Challenges and Possible Solutions? A Qualitative Study. International Journal of Environmental Research and Public Health, 19(19), Article 12030. https://doi.org/10.3390/ijerph191912030

Despite strategies to enable Health Care Professionals (HCPs) to give physical activity (PA) advice to patients, this appears to be rarely done in consultations. The aims of the present study were to gain an understanding of doctors’ awareness of cur... Read More about UK Doctors Delivering Physical Activity Advice: What Are the Challenges and Possible Solutions? A Qualitative Study.

Implementation lessons learnt when trialling palliative care interventions in the intensive care unit: relationships between determinants, implementation strategies, and models of delivery-a systematic review protocol (2022)
Journal Article
Meddick-Dyson, S. A., Boland, J. W., Pearson, M., Greenley, S., Gambe, R., Budding, J. R., & Murtagh, F. E. (2022). Implementation lessons learnt when trialling palliative care interventions in the intensive care unit: relationships between determinants, implementation strategies, and models of delivery-a systematic review protocol. Systematic reviews, 11(1), Article 186. https://doi.org/10.1186/s13643-022-02054-8

BACKGROUND: Heterogeneity amongst palliative care interventions in the intensive care unit (ICU) and their outcomes has meant that, even when found to be effective, translation of evidence into practice is hindered. Previous evidence reviews have sug... Read More about Implementation lessons learnt when trialling palliative care interventions in the intensive care unit: relationships between determinants, implementation strategies, and models of delivery-a systematic review protocol.

Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit (2022)
Journal Article
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942

Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: C... Read More about Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit.

Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit (2022)
Journal Article
Pieri, B., Deshmukh, H., Wilmot, E. G., Choudhary, P., Shah, N., Gregory, R., …Sathyapalan, T. (2023). Impaired awareness of hypoglycaemia: Prevalence and associated factors before and after FreeStyle Libre use in the Association of British Clinical Diabetologists audit. Diabetes, Obesity and Metabolism, 25(1), 302-305. https://doi.org/10.1111/dom.14841

Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis (2022)
Journal Article
Lathan, R., Sidapra, M., Yiasemidou, M., Long, J., Totty, J., Smith, G., & Chetter, I. (2022). Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis. npj Digital Medicine, 5(1), Article 108. https://doi.org/10.1038/s41746-022-00655-0

The Sars-CoV-2 pandemic catalysed integration of telemedicine worldwide. This systematic review assesses it’s accuracy for diagnosis of Surgical Site Infection (SSI). Databases were searched for telemedicine and wound infection studies. All types of... Read More about Diagnostic accuracy of telemedicine for detection of surgical site infection: a systematic review and meta-analysis.

Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR (2022)
Journal Article
Saldanha, P. A., Bolanle, I. O., Palmer, T. M., Nikitenko, L. L., & Rivero, F. (2022). Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR. Cells, 11(15), Article 2315. https://doi.org/10.3390/cells11152315

The myosin light chain phosphatase target subunit 1 (MYPT1), encoded by the PPP1R12A gene, is a key component of the myosin light chain phosphatase (MLCP) protein complex. MYPT1 isoforms have been described as products of the cassette-type alternativ... Read More about Complex Transcriptional Profiles of the PPP1R12A Gene in Cells of the Circulatory System as Revealed by In Silico Analysis and Reverse Transcription PCR.

Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review (2022)
Journal Article
Patterson, M., Greenley, S., Ma, Y., Bullock, A., Curry, J., Smithson, J., …Johnson, M. J. (2022). Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review. BMJ supportive & palliative care, Article 003492. https://doi.org/10.1136/bmjspcare-2021-003492

Background: Parenteral nutrition (PN) and palliative venting gastrostomies (PVG) are two interventions used clinically to manage inoperable malignant bowel obstruction (MBO); however, little is known about their role in clinical and quality-of-life o... Read More about Inoperable malignant bowel obstruction: palliative interventions outcomes-mixed-methods systematic review.

A survey of surgical site infection prevention practice in UK vascular surgery (2022)
Journal Article
lathan, R., yiasemidou, M., long, J., Mohamed, A., hitchman, L., smith, G., & Chetter, I. (2022). A survey of surgical site infection prevention practice in UK vascular surgery. Journal of Vascular Societies Great Britain and Ireland, 1(4), 117-123. https://doi.org/10.54522/jvsgbi.2022.030

Background: Surgical site infections (SSI) have a significant impact on morbidity and mortality within vascular surgery. Despite the publication of several guidelines, there is a lack of consensus regarding the most effective perioperative practice t... Read More about A survey of surgical site infection prevention practice in UK vascular surgery.

Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure (2022)
Journal Article
Kazmi, S., Kambhampati, C., Cleland, J., Cuthbert, J., Kazmi, K. S., Pellicori, P., …Clark, A. L. (2022). Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure. ESC Heart Failure, https://doi.org/10.1002/ehf2.14028

Aims: Risk changes with the progression of disease and the impact of treatment. We developed a dynamic risk stratification Markov chain model using artificial intelligence in patients with chronic heart failure (CHF). Methods and results: We describe... Read More about Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure.