Dr Harshal Deshmukh H.Deshmukh@hull.ac.uk
Clinical Senior Lecturer in Diabetes
Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit
Deshmukh, Harshal; Wilmot, Emma; Pieri, Beatrice; Choudhary, Pratik; Shah, Najeeb; Gregory, Robert; Kilvert, Anne; Lumb, Alistair; Christian, Peter; Barnes, Dennis; Patmore, Jane; Walton, Chris; Ryder, Robert E.J.; Sathyapalan, Thozhukat
Authors
Emma Wilmot
Beatrice Pieri
Pratik Choudhary
Najeeb Shah
Robert Gregory
Anne Kilvert
Alistair Lumb
Peter Christian
Dennis Barnes
Jane Patmore
Chris Walton
Robert E.J. Ryder
Professor Thozhukat Sathyapalan T.Sathyapalan@hull.ac.uk
Professor of Diabetes, Endocrinology and Metabolism
Abstract
Aims: The aim of this study was to understand the relationship between time in range (TIR) achieved using the isCGM with changes in glycaemic control, diabetes-related distress (DRD) and resource utilisation in people living with diabetes. Methods: Clinicians from 106 National Health System (NHS) UK hospitals submitted isCGM user baseline and follow-up data in a web-based tool held within the UK NHS network. Linear regression analysis was used to identify the relationship between follow-up glucose TIR (3.9–10 mmol/L) categories (TIR% 50–70 and TIR% >70) with change in haemoglobin A1c (HbA1c), DRD and Gold score (measure of hypoglycaemia unawareness, where a score ≥4 suggests impaired awareness of hypoglycaemia). Results: Of 16,427 participants, 1241 had TIR follow-up data available. In this cohort, the mean TIR was 44.8% (±22.5). With the use of isCGM, at 7.9 months mean follow-up, improvements were observed in HbA1c (−6.9 [13.5] mmol/mol, p < 0.001), Gold score (−0.35 [1.5], p < 0.001) and Diabetes Distress Screening (−0.73 [1.23], p < 0.001). In the regression analysis restricted to people living with type 1 diabetes, TIR% 50–70 was associated with a −8.9 mmol/mol (±0.6, p < 0.001) reduction in HbA1c; TIR% >70 with a −14 mmol/mol (±0.8, p < 0.001) reduction in HbA1c. Incremental improvement in TIR% was also associated with significant improvements in Gold score and DRD. TIR% >70 was associated with no hospital admissions due to hypoglycaemia, hyperglycaemia/diabetic ketoacidosis, and a 60% reduction in the paramedic callouts and 77% reduction in the incidence of severe hypoglycaemia. Conclusion: In a large cohort of UK isCGM users, we demonstrate a significant association of higher TIR% with improvement in HbA1c, hypoglycaemia awareness, DRD and resource utilisation.
Citation
Deshmukh, H., Wilmot, E., Pieri, B., Choudhary, P., Shah, N., Gregory, R., Kilvert, A., Lumb, A., Christian, P., Barnes, D., Patmore, J., Walton, C., Ryder, R. E., & Sathyapalan, T. (2022). Time in range following flash glucose monitoring: Relationship with glycaemic control, diabetes-related distress and resource utilisation in the Association of British Clinical Diabetologists national audit. Diabetic medicine, Article e14942. https://doi.org/10.1111/dme.14942
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 15, 2022 |
Online Publication Date | Aug 26, 2022 |
Publication Date | 2022 |
Deposit Date | Sep 19, 2022 |
Publicly Available Date | Aug 27, 2023 |
Journal | Diabetic Medicine |
Electronic ISSN | 1464-5491 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Article Number | e14942 |
DOI | https://doi.org/10.1111/dme.14942 |
Public URL | https://hull-repository.worktribe.com/output/4077328 |
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Copyright Statement
©2022 The authors.
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