All Outputs (6)

Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma? (2017)
Journal Article
Morjaria, J. B., Rigby, A. S., & Morice, A. H. (2017). Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?. European respiratory journal, 50(6), Article 1701366. https://doi.org/10.1183/13993003.01366-2017

Copyright © ERS 2017. Little is known of the long-term symptom profile in uncontrolled asthma and whether symptoms can predict distinct phenotypes. The primary objective of these analyses was to assess diurnal profile of cough and wheeze in an uncont... Read More about Asthma phenotypes: Do cough and wheeze predict exacerbations in persistent asthma?.

Does FeNO Predict Clinical Characteristics in Chronic Cough? (2017)
Journal Article
Sadeghi, M. H., Wright, C. E., Hart, S., Crooks, M., & Morice, A. H. (2018). Does FeNO Predict Clinical Characteristics in Chronic Cough?. Lung, 196(1), 59-64. https://doi.org/10.1007/s00408-017-0074-6

© 2017, The Author(s). Purpose: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. Methods: We have studied consecutive patients attending a sp... Read More about Does FeNO Predict Clinical Characteristics in Chronic Cough?.

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation (2017)
Journal Article
Crooks, M. G., den Brinker, A., Hayman, Y., Williamson, J. D., Innes, A., Wright, C. E., …Morice, A. H. (2017). Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation. Lung, 195(3), 289-294. https://doi.org/10.1007/s00408-017-9996-2

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deteriorat... Read More about Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation.

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? (2017)
Journal Article
Hayman, Y. A., Sadofsky, L. R., Williamson, J. D., Hart, S. P., & Morice, A. H. (2017). The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?. Ers Monograph, 3(1), 00026-2016. https://doi.org/10.1183/23120541.00026-2016

Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR. The proposed mechanis... Read More about The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?.

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study (2017)
Journal Article
Morjaria, J. B., Morice, A. H., Morice, A., Rigby, A., & Morjaria, J. (2017). Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung, 195(3), 281-288. https://doi.org/10.1007/s00408-017-9990-8

Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory event... Read More about Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study.

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity? (2017)
Journal Article
Fowles, H. E., Rowland, T., Wright, C., & Morice, A. (2017). Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?. European respiratory journal, 49(2), Article ARTN 1601452. https://doi.org/10.1183/13993003.01452-2016

Recent studies have demonstrated that blockade of P2X3 adenosine triphosphate (ATP) receptors may profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensiti... Read More about Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?.