Does FeNO Predict Clinical Characteristics in Chronic Cough?

Sadeghi, Mahboobeh Haji; Wright, Caroline E.; Hart, Simon; Crooks, Michael; Morice, Alyn H.

Abstract

© 2017, The Author(s). Purpose: To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype. Methods: We have studied consecutive patients attending a specialist cough clinic. 30 patients with high FeNO (> 30 ppb) and 20 patients with low FeNO (< 20 ppb) were recruited. Results: There was a significant correlation between FeNO, B-Eos and sputum eosinophil count (p < 0.001). The number of recorded coughs in 24 h and HARQ scores were significantly (p < 0.05) higher in patients with a low FeNO. In contrast to the high FeNO group (48%), the greater proportion of these patients were women (90%). LCQ scores were worse in the low FeNO group but it was not significant. Conclusion: A strong relationship between FeNO, blood eosinophils and sputum eosinophils confirming phenotypic identity was observed. Whether the observed gender disparity accounts for the different cough frequency characteristics is unknown.

Citation

Sadeghi, M. H., Wright, C. E., Hart, S., Crooks, M., & Morice, A. H. (2018). Does FeNO Predict Clinical Characteristics in Chronic Cough?. Lung, 196(1), 59-64. https://doi.org/10.1007/s00408-017-0074-6

• Journal Article Type: Article
• Acceptance Date: Nov 17, 2017
• Online Publication Date: Nov 25, 2017
• Publication Date: 2018-02
• Deposit Date: May 10, 2022
• Publicly Available Date: May 16, 2022
• Journal: Lung
• Print ISSN: 0341-2040
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 196
• Issue: 1
• Pages: 59-64
• DOI: https://doi.org/10.1007/s00408-017-0074-6
• Keywords: Chronic cough; FeNO; Airway inflammation
• Public URL: https://hull-repository.worktribe.com/output/3565512