All Outputs (700)

Management of patients with chronic cough using a clinical protocol: A prospective observational study (2013)
Journal Article
Ojoo, O. C., Everett, C. F., Mulrennan, S. A., Faruqi, S., Kastelik, J. A., & Morice, A. H. (2013). Management of patients with chronic cough using a clinical protocol: A prospective observational study. Cough, 9(1), Article 2. https://doi.org/10.1186/1745-9974-9-2

Background and aims: Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily available. We wanted t... Read More about Management of patients with chronic cough using a clinical protocol: A prospective observational study.

Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697 (2013)
Journal Article
Agarwal, V., Hodgkinson, V. C., Eagle, G. L., Scaife, L., Lind, M. J., & Cawkwell, L. (2013). Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. International Journal of Oncology, 42(3), 1088-1092. https://doi.org/10.3892/ijo.2013.1784

We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed. Here, we used a novel proteomic approach to explore the mechanism of acti... Read More about Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.

Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design (2013)
Journal Article
Kotecha, D., Manzano, L., Altman, D. G., Krum, H., Erdem, G., Williams, N., Flather, M. D., & Beta-Blockers in Heart Failure Collaborative Group. (2013). Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design. Systematic reviews, 2(1), Article 7. https://doi.org/10.1186/2046-4053-2-7

The Beta-Blockers in Heart Failure Collaborative Group (BB-HF) was formed to obtain and analyze individual patient data from the major randomized controlled trials of beta-blockers in heart failure. Even though beta-blockers are an established treatm... Read More about Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design.

TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis (2013)
Journal Article
Zeng, B., Yuan, C., Yang, X., Atkin, S. L., & Xu, S.-Z. (2013). TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis. Current Cancer Drug Targets, 13(1), 103-116. https://doi.org/10.2174/156800913804486629

TRPC channels are Ca2+-permeable cationic channels controlling Ca2+ influx response to the activation of G protein-coupled receptors and protein tyrosine kinase pathways or the depletion of Ca2+ stores. Here we aimed to investigate whether TRPC can a... Read More about TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis.

PTEN protein expression in malignant pleural mesothelioma (2012)
Journal Article
Agarwal, V., Campbell, A., Beaumont, K. L., Cawkwell, L., & Lind, M. J. (2013). PTEN protein expression in malignant pleural mesothelioma. Tumor Biology, 34(2), 847-851. https://doi.org/10.1007/s13277-012-0615-9

Malignant pleural mesothelioma is associated with poor prognosis and despite recent advances in chemotherapy, the median survival is still approximately 12 months. Loss of phosphatase and tensin homolog (PTEN) protein expression may lead to constitut... Read More about PTEN protein expression in malignant pleural mesothelioma.

Control strategies for robotic manipulators (2012)
Presentation / Conference Contribution
Khan, M. F., Ul Islam, R., & Iqbal, J. (2012, October). Control strategies for robotic manipulators. Presented at 2012 International Conference on Robotics and Artificial Intelligence (ICRAI), Rawalpindi, Pakistan

This survey is aimed at presenting the major robust control strategies for rigid robot manipulators. The techniques discussed are feedback linearization/Computed torque control, Variable structure compensator, Passivity based approach and Disturbance... Read More about Control strategies for robotic manipulators.

Oscillatory neuronal dynamics associated with manual acupuncture: A magnetoencephalography study using beamforming analysis (2012)
Journal Article
Asghar, A., Johnson, R., Woods, W., Green, G. G., Lewith, G., & Macpherson, H. (2012). Oscillatory neuronal dynamics associated with manual acupuncture: A magnetoencephalography study using beamforming analysis. Frontiers in human neuroscience, 6(OCTOBER 2012), Article 303. https://doi.org/10.3389/fnhum.2012.00303

Magnetoencephalography (MEG) enables non-invasive recording of neuronal activity, with reconstruction methods providing estimates of underlying brain source locations and oscillatory dynamics from externally recorded neuromagnetic fields. The aim of... Read More about Oscillatory neuronal dynamics associated with manual acupuncture: A magnetoencephalography study using beamforming analysis.

Towards a sociology of 10–12 year olds? Emerging methodological issues in the ‘new’ social studies of childhood (2012)
Journal Article
McNamee, S., & Seymour, J. (2013). Towards a sociology of 10–12 year olds? Emerging methodological issues in the ‘new’ social studies of childhood. Childhood, 20(2), 156-168. https://doi.org/10.1177/0907568212461037

This article reports on an analysis of 320 empirical research articles published between 1993 and 2010 in three of the leading ‘childhood’ journals. The study looked to establish the potential samples used in accounts of empirical research studies wi... Read More about Towards a sociology of 10–12 year olds? Emerging methodological issues in the ‘new’ social studies of childhood.

Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis (2012)
Journal Article
Fahim, A., Crooks, M., Wilmot, R., Campbell, A. P., Morice, A., & Hart, S. (2012). Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology : official journal of the Asian Pacific Society of Respirology, 17(8), 1247-1252. https://doi.org/10.1111/j.1440-1843.2012.02231.x

Background and objective: Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer.... Read More about Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis.

The Vicorder device compared with SphygmoCor in the assessment of carotid-femoral pulse wave velocity in patients with peripheral arterial disease (2012)
Journal Article
Shahin, Y., Barakat, H., Barnes, R., & Chetter, I. (2013). The Vicorder device compared with SphygmoCor in the assessment of carotid-femoral pulse wave velocity in patients with peripheral arterial disease. Hypertension Research, 36(3), 208-212. https://doi.org/10.1038/hr.2012.144

To assess the reliability and reproducibility of the Vicorder's carotid-femoral pulse wave velocity (cfPWV) measurements in patients with peripheral arterial disease (PAD) and to compare between cfPWV measurements obtained using the Vicorder with tho... Read More about The Vicorder device compared with SphygmoCor in the assessment of carotid-femoral pulse wave velocity in patients with peripheral arterial disease.

Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx (2012)
Journal Article
Zeng, B., Chen, G.-L., & Xu, S. Z. (2012). Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx. Biochemical Pharmacology, 84(8), 1024-1035. https://doi.org/10.1016/j.bcp.2012.07.013

STIM1 is a Ca 2+ sensing molecule. Once the Ca 2+ stores are depleted, STIM1 moves towards the plasma membrane (PM) (translocation), forms puncta (clustering), and triggers store-operated Ca 2+ entry (SOCE). Although this process has been regarded as... Read More about Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx.

Fundoplication in chronic intractable cough (2012)
Journal Article
Faruqi, S., Sedman, P., Jackson, W., Molyneux, I., & Morice, A. H. (2012). Fundoplication in chronic intractable cough. Cough, 8(1), Article 3. https://doi.org/10.1186/1745-9974-8-3

Background: Airway reflux is a common cause of chronic cough and this is often refractory to medical therapy. Surgery in the form of Nissen fundoplication has been highly successful in the treatment of the classic reflux symptoms of heartburn and dys... Read More about Fundoplication in chronic intractable cough.

MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein (2012)
Journal Article
Schenková, K., Lutz, J., Kopp, M., Ramos, S., & Rivero, F. (2012). MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Journal of Molecular Biology, 422(5), 659-673. https://doi.org/10.1016/j.jmb.2012.06.016

RhoBTB (BTB stands for broad-complex, tramtrack, bric à brac) proteins are tumor suppressors involved in the formation of cullin 3 (Cul3)-dependent ubiquitin ligase complexes. However, no substrates of RhoBTB-Cul3 ubiquitin ligase complexes have been... Read More about MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.

The effect of a 3-month supervised exercise programme on gait parameters of patients with peripheral arterial disease and intermittent claudication (2012)
Journal Article
King, S., Vanicek, N., Mockford, K. A., & Coughlin, P. A. (2012). The effect of a 3-month supervised exercise programme on gait parameters of patients with peripheral arterial disease and intermittent claudication. Clinical biomechanics, 27(8), 845-851. https://doi.org/10.1016/j.clinbiomech.2012.05.002

Background
The management of peripheral arterial disease with intermittent claudication includes angioplasty, pharmaceutical therapy, risk factor modification and exercise therapy. Supervised exercise programmes are used sporadically but may improve... Read More about The effect of a 3-month supervised exercise programme on gait parameters of patients with peripheral arterial disease and intermittent claudication.

Being parented?: children and young people's engagement with parenting activities (2012)
Book Chapter
McNamee, S., & Seymour, J. (2012). Being parented?: children and young people's engagement with parenting activities. In Learning from the children: childhood, culture and identity in a changing world (92 - 107). Berghahn

Response of face-selective brain regions to trustworthiness and gender of faces (2012)
Journal Article
Mattavelli, G., Andrews, T. J., Asghar, A. U., Towler, J. R., & Young, A. W. (2012). Response of face-selective brain regions to trustworthiness and gender of faces. Neuropsychologia, 50(9), 2205-2211. https://doi.org/10.1016/j.neuropsychologia.2012.05.024

Neuropsychological and neuroimaging studies have demonstrated a role for the amygdala in processing the perceived trustworthiness of faces, but it remains uncertain whether its responses are linear (with the greatest response to the least trustworthy... Read More about Response of face-selective brain regions to trustworthiness and gender of faces.

Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels (2012)
Journal Article
Chen, G.-L., Zeng, B., Eastmond, S., Elsenussi, S. E., Boa, A. N., & Xu, S.-Z. (2012). Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels. British Journal of Pharmacology, 167(6), 1232-1243. https://doi.org/10.1111/j.1476-5381.2012.02058.x

BACKGROUND: Fenamate analogues, econazole and 2-APB are inhibitors of TRPM2 channels, which have been used as research tools. However, these compounds have different chemical structures and therapeutic applications. Here we aimed to investigate the p... Read More about Pharmacological comparison of novel synthetic fenamate analogues with econazole and 2-APB on the inhibition of TRPM2 channels.

Chronotropic incompetence and survival in chronic heart failure (2012)
Journal Article
Al-Najjar, Y., Witte, K. K., & Clark, A. L. (2012). Chronotropic incompetence and survival in chronic heart failure. International journal of cardiology, 157(1), 48-52. https://doi.org/10.1016/j.ijcard.2010.11.018

Background: Failure of the heart rate to rise normally during an incremental exercise test is termed chronotropic incompetence (CI). It is common in patients with chronic heart failure (CHF), and we wanted to explore the relation between CI and outco... Read More about Chronotropic incompetence and survival in chronic heart failure.

Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies (2012)
Journal Article
Fahim, A., Chong, M. C., Crooks, M. G., & Hart, S. P. (2012). Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung, 190(4), 451-458. https://doi.org/10.1007/s00408-012-9390-z

PurposeIdiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies... Read More about Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies.

Clinical Reasoning in Medicine: Developing Students' meta-cognitive skills (2012)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2012, May). Clinical Reasoning in Medicine: Developing Students' meta-cognitive skills. Poster presented at University of York Teaching and Learning Conference, York

This poster outlines the progress of the authors’ project in introducing formal Clinical Reasoning Skills sessions.

This project was instituted on the basis of observations of students’ performances in live examinations in years 4 / 5 of our five... Read More about Clinical Reasoning in Medicine: Developing Students' meta-cognitive skills.