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Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims
Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART) (2010)
Journal Article
Mazari, F. A. K., Mockford, K., Vanicek, N., Barnett, C., Khan, J. A., Brown, B., Smith, L., Polman, R. C., Hancock, A., & Chetter, I. C. (2010). Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART). Journal of vascular surgery, 52(6), 1564-1571. https://doi.org/10.1016/j.jvs.2010.07.006

Purpose: To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Methods: Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened... Read More about Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART).

Physical activity preferences and type 2 diabetes: Exploring demographic, cognitive, and behavioral differences (2010)
Journal Article
Forbes, C. C., Plotnikoff, R. C., Courneya, K. S., & Boulé, N. G. (2010). Physical activity preferences and type 2 diabetes: Exploring demographic, cognitive, and behavioral differences. Diabetes Educator, 36(5), 801-815. https://doi.org/10.1177/0145721710378538

Purpose

The purpose of this study was to examine physical activity counseling and program preferences in a sample of adults with type 2 diabetes. Specifically, the objectives were to determine physical activity preferences (objective 1), and whether... Read More about Physical activity preferences and type 2 diabetes: Exploring demographic, cognitive, and behavioral differences.

The role of blood pressure variability in the development of nephropathy in type 1 diabetes (2010)
Journal Article
Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2010). The role of blood pressure variability in the development of nephropathy in type 1 diabetes. Diabetes Care, 33(11), 2442-2447. https://doi.org/10.2337/dc10-1000

OBJECTIVE - Increases in blood pressure and visit-to-visit variability have both been found to independently increase the likelihood of cardiovascular events in nondiabetic individuals. This study has investigated whether each may also influence the... Read More about The role of blood pressure variability in the development of nephropathy in type 1 diabetes.

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species (2010)
Journal Article
Cheah, L.-T., Dou, Y. H., Seymour, A. M. L., Dyer, C. E., Haswell, S. J., Wadhawan, J. D., & Greenman, J. (2010). Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab on a chip, 10(20), 2720-2726. https://doi.org/10.1039/c004910g

A microfluidic device has been developed to maintain viable heart tissue samples in a biomimetic microenvironment. This device allows rat or human heart tissue to be studied under pseudo in vivo conditions. Effluent levels of lactate dehydrogenase an... Read More about Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species.

Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity (2010)
Journal Article
Carradice, D., Mazari, F. A., Mekako, A., Hatfield, J., Allgar, V., & Chetter, I. (2010). Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 40(3), 393-398. https://doi.org/10.1016/j.ejvs.2010.04.010

Aim: The durability of occlusion post endovenous laser therapy (EVLT) for varicose veins is linked to the magnitude of energy delivered to the vein and consequently increasing amounts of energy are employed. The aim of this study is to establish whet... Read More about Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity.

A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study (2010)
Journal Article
Barton, R., English, A., Nabb, S., Rigby, A. S., & Johnson, M. J. (2010). A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study. Lung Cancer, 70(3), 313-319. https://doi.org/10.1016/j.lungcan.2010.03.007

Background: Breathlessness remains a refractory symptom in malignant lung disease. Breathing training is an effective, non-pharmacological intervention but it is unclear how this should be delivered. This feasibility study aimed to assess recruitment... Read More about A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study.

Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status (2010)
Journal Article
Hodgkinson, V. C., Eagle, G. L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2010). Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status. Cancer Letters, 294(1), 13-24. https://doi.org/10.1016/j.canlet.2010.01.036

This review describes and discusses the advantages and limitations of proteomic approaches in the identification of biomarkers associated with chemotherapy resistance. Both gel-based (two-dimensional polyacrylamide gel electrophoresis) and gel-free (... Read More about Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status.

A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta (2009)
Journal Article
Bishop, N., Harrison, R., Ahmed, F., Shaw, N., Eastell, R., Campbell, M., Knowles, E., Hill, C., Hall, C., Chapman, S., Sprigg, A., & Rigby, A. (2010). A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta. Journal of Bone and Mineral Research, 25(1), 32-40. https://doi.org/10.1359/jbmr.090712

Moderate to severe osteogenesis imperfecta is associated with multiple fractures in childhood. There are no published data regarding the effects of third-generation bisphosphonates in these children. This randomized study investigated which of three... Read More about A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta.

Acupuncture needling sensation: the neural correlates of deqi using fMRI (2009)
Journal Article
Asghar, A. U. R., Green, G., Lythgoe, M. F., Lewith, G., & MacPherson, H. (2010). Acupuncture needling sensation: the neural correlates of deqi using fMRI. Brain research, 1315, 111-118. https://doi.org/10.1016/j.brainres.2009.12.019

The needling sensation of deqi is considered by most acupuncturists to be an important component of acupuncture, yet neuroimaging research that investigates this needle sensation has been limited. In this study we have investigated the effect of deqi... Read More about Acupuncture needling sensation: the neural correlates of deqi using fMRI.

Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery (2009)
Journal Article
Mekako, A. I., Chetter, I. C., Coughlin, P. A., Hatfield, J., & McCollum, P. T. (2010). Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery. British journal of surgery, 97(1), 29-36. https://doi.org/10.1002/bjs.6849

Background: Wound infection rates of up to 16 per cent are reported following varicose vein surgery and the value of antibiotic prophylaxis in clean surgery remains unclear. Methods: Some 443 patients undergoing varicose vein surgery randomly receive... Read More about Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery.

TRPA1 agonists evoke coughing in guinea pig and human volunteers (2009)
Journal Article
Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., Maher, S. A., Freund-Michel, V., & Morice, A. H. (2009). TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine, 180(11), 1042-1047. https://doi.org/10.1164/rccm.200905-0665OC

Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is als... Read More about TRPA1 agonists evoke coughing in guinea pig and human volunteers.

Lack of diastolic reserve in patients with heart failure and normal ejection fraction (2009)
Journal Article
Chattopadhyay, S., Alamgir, M. F., Nikitin, N. P., Rigby, A. S., Clark, A. L., & Cleland, J. G. F. (2010). Lack of diastolic reserve in patients with heart failure and normal ejection fraction. Circulation. Heart failure, 3(1), 35-43. https://doi.org/10.1161/CIRCHEARTFAILURE.108.824888

Background-The genesis of symptoms in patients with heart failure (HF) and normal ejection fraction (HFNEF) is unclear. Most investigations of HFNEF have focused on cardiac function at rest although most of these patients are breathless only on exerc... Read More about Lack of diastolic reserve in patients with heart failure and normal ejection fraction.

Intramucosal carcinoma on biopsy reliably predicts invasive colorectal cancer (2009)
Journal Article
MacDonald, A. W., Tayyab, M., Arsalani-Zadeh, R., Hartley, J. E., & Monson, J. R. T. (2009). Intramucosal carcinoma on biopsy reliably predicts invasive colorectal cancer. Annals of Surgical Oncology, 16(12), 3267-3270. https://doi.org/10.1245/s10434-009-0727-7

Background: The diagnosis of invasive malignancy on biopsies from colorectal neoplasms can be challenging. The concept of intramucosal carcinoma as an indicator of invasive malignancy is somewhat controversial within histopathology circles despite cu... Read More about Intramucosal carcinoma on biopsy reliably predicts invasive colorectal cancer.

Quality assurance in flexible sigmoidoscopy: Medical and nonmedical endoscopists (2009)
Journal Article
Maslekar, S., Waudby, P., Avery, G., Monson, J. R. T., & Duthie, G. S. (2010). Quality assurance in flexible sigmoidoscopy: Medical and nonmedical endoscopists. Surgical Endoscopy, 24(1), 89-93. https://doi.org/10.1007/s00464-009-0553-9

Purpose: The clinical assessment of position in colon and hence completion during flexible sigmoidoscopy (FS) is believed to be inaccurate. The technique of applying endomucosal clips with follow-up X-ray has previously been used for establishing com... Read More about Quality assurance in flexible sigmoidoscopy: Medical and nonmedical endoscopists.

Acquired microcephaly: causes, patterns, motor and IQ effects, and associated growth changes (2009)
Journal Article
Baxter, P. S., Rigby, A. S., Rotsaert, M. H. E. P. D., & Wright, I. (2009). Acquired microcephaly: causes, patterns, motor and IQ effects, and associated growth changes. Pediatrics, 124(2), 590-595. https://doi.org/10.1542/peds.2008-2784

OBJECTIVES: The goals were to identify and to classify causes and growth patterns of acquired (or progressive) microcephaly and to look for hypothesized correlations between causes, growth patterns, and developmental quotient/IQ. METHODS: Fifty-one c... Read More about Acquired microcephaly: causes, patterns, motor and IQ effects, and associated growth changes.