All Outputs (652)

The prognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: A retrospective cross-sectional study (2024)
Journal Article
Palmer, J., Pymer, S., Smith, G., Ingle, L., Harwood, A., & Chetter, I. (online). The prognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: A retrospective cross-sectional study. Journal of Vascular Societies Great Britain and Ireland, https://doi.org/10.54522/jvsgbi.2024.124

Background: This study aims to explore the prognostic value of simple frailty and malnutrition tools for determining postoperative outcomes at 30 days and 1 year in patients with CLTI undergoing major surgery. Methods: This was a single-centre retr... Read More about The prognostic value of simple frailty and malnutrition screening tools for determining surgical risk in patients with chronic limb threatening ischaemia undergoing major vascular surgery: A retrospective cross-sectional study.

Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study (2024)
Journal Article
Cuthbert, J. J., Soyiri, I., Lomax, S. J., Turgoose, J., Fuat, A., Cohen, J., & Clark, A. L. (2024). Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study. Heart, 110(12), Article 323577. https://doi.org/10.1136/heartjnl-2023-323577

Background Loop diuretics are commonly prescribed in the community, not always to patients with a recorded diagnosis of heart failure (HF). The rate of HF events in patients prescribed loop diuretics without a diagnosis of HF is unknown. Methods... Read More about Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study.

Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty (2024)
Thesis
Randall, J. (2024). Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4659916

Aim Non-anaemic iron deficiency although identified as a potential area for improving patient outcome in the literature, its effect on patient outcomes post-surgery is an under researched topic, with numerous gaps in the published literature. The ai... Read More about Evaluation of iron supplementation and its effect on postoperative outcomes in non-anaemic iron deficient patients undergoing surgery, with a focus on lower limb arthroplasty.

The association between completion of supervised exercise therapy and long-term outcomes in patients with intermittent claudication, concomitant sarcopenia and cardiometabolic multimorbidity (2024)
Journal Article
Ravindhran, B., Igwe, C., Nazir, S., Harwood, A., Lathan, R., Carradice, D., Smith, G., Chetter, I., & Pymer, S. (in press). The association between completion of supervised exercise therapy and long-term outcomes in patients with intermittent claudication, concomitant sarcopenia and cardiometabolic multimorbidity. Annals of vascular surgery,

The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables (2024)
Thesis
Kassianides, X. (2024). The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4659777

Background: Modern intravenous iron preparations (e.g. ferric derisomaltose (FDI), ferric carboxymaltose (FCM)) are commonly used in non-dialysis-dependent chronic kidney disease (CKD) patients. Despite similar efficacy and safety in terms of previou... Read More about The differential effect of intravenous iron in patients with non-dialysis chronic kidney disease in terms of fibroblast growth factor 23, phosphate, bone metabolism, functional status and quality of life and cardiovascular variables.

The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation (2024)
Thesis
Greaves, J. (2024). The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4609527

The proper activation and subsequent differentiation of naive CD4+ T cells into effector T helper and regulatory T cells is vital for directing an appropriate adaptive immune response to specific infections. Recent evidence has identified long non-co... Read More about The regulatory role of Malat1 on the alternative splicing factor SRSF1 during CD4+ T cell differentiation.

Hospital admissions in the last year of life of patients with heart failure (2024)
Journal Article
AI Abel, A., Samuel, N. A., Cuthbert, J. J., Brown, O. I., Pellicori, P., Kazmi, S., GF Cleland, J., Johnson, M., & Clark, A. L. (2024). Hospital admissions in the last year of life of patients with heart failure. European Heart Journal - Quality of Care and Clinical Outcomes, 10(2), 168-175. https://doi.org/10.1093/ehjqcco/qcad047

Aim To explore the frequency, causes, and pattern of hospitalisation for patients with chronic heart failure (HF) in the 12 months preceding death. We also investigated cause of death. Methods Patients referred to a secondary care HF clinic were rout... Read More about Hospital admissions in the last year of life of patients with heart failure.

A feasibility survey to inform trial design investigating surgical site infection prevention in vascular surgery (2024)
Journal Article
Lathan, R., Hitchman, L., Long, J., Gwilym, B., Wall, M., Juszczak, M., Smith, G., Popplewell, M., Bosanquet, D., Hinchliffe, R., Pinkney, T., & Chetter, I. (2024). A feasibility survey to inform trial design investigating surgical site infection prevention in vascular surgery. Journal of Vascular Societies Great Britain and Ireland, 3(2), 76-83. https://doi.org/10.54522/jvsgbi.2024.116

Introduction: Current surgical site infection (SSI) prevention guidance indicates low-quality evidence supporting many of their recommendations. Subsequently, there is substantial variation in practice and often implementation of unsubstantiated inte... Read More about A feasibility survey to inform trial design investigating surgical site infection prevention in vascular surgery.

Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis (2024)
Thesis
Muscutt, E. W. (2024). Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis. (Thesis). University of Hull and University of York. Retrieved from https://hull-repository.worktribe.com/output/4557553

Visceral leishmaniasis (VL) causes immune and haematological dysfunction and is fatal in >95% of cases if left untreated. While macrophages are vital for efficient Leishmania parasite clearance, parasite-macrophage interactions are critical for VL pr... Read More about Roles of TRIM24 in macrophage activation and experimental visceral leishmaniasis.

Tailored risk assessment and forecasting in intermittent claudication (2024)
Journal Article
Ravindhran, B., Prosser, J., Lim, A., Lathan, R., Mishra, B., Hitchman, L., Smith, G. E., Carradice, D., Thakker, D., Chetter, I. C., & Pymer, S. (2024). Tailored risk assessment and forecasting in intermittent claudication. BJS Open, 8(1), Article zrad166. https://doi.org/10.1093/bjsopen/zrad166

Background: Guidelines recommend cardiovascular risk reduction and supervised exercise therapy as the first line of treatment in intermittent claudication, but implementation challenges and poor patient compliance lead to significant variation in man... Read More about Tailored risk assessment and forecasting in intermittent claudication.

Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics (2024)
Journal Article
Cuthbert, J. J., & Clark, A. L. (2024). Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics. Current Heart Failure Reports, 21(2), 101-114. https://doi.org/10.1007/s11897-024-00643-3

Purpose of Review: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion—loop... Read More about Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics.

Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation (2024)
Journal Article
Ssemmondo, E., Deshmukh, H., Wilmot, E. G., Adeleke, K. A., Shah, N., Walton, C., Barnes, D., Ryder, R. E., & Sathyapalan, T. (2024). Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation. Diabetes, Obesity and Metabolism, 26(4), 1340-1345. https://doi.org/10.1111/dom.15435

Aim: To understand the effect of intermittently scanned continuous glucose monitoring (isCGM) in people with diabetes with a ‘psychosocial’ indication for access. Methods: The study utilized baseline and follow-up data from the Association of British... Read More about Effect of intermittently scanned continuous glucose monitoring in people with diabetes with a psychosocial indication for initiation.

Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study (2024)
Journal Article
Deshmukh, H., Adeleke, K., Wilmot, E. G., Folwell, A., Barnes, D., Walker, N., Saunders, S., Ssemmondo, E., Walton, C., Patmore, J., Ryder, R. E., & Sathyapalan, T. (2024). Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study. Diabetes, Obesity and Metabolism, 26(4), 1333-1339. https://doi.org/10.1111/dom.15434

Aims: To evaluate the clinical features and impact of flash glucose monitoring in older adults with type 1 diabetes (T1D) across age groups defined as young-old, middle-old, and old-old. Materials and Methods: Clinicians were invited to submit anonym... Read More about Clinical features of type 1 diabetes in older adults and the impact of intermittently scanned continuous glucose monitoring: An Association of British Clinical Diabetologists (ABCD) study.

Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom (2024)
Journal Article
Parker, P., Twiddy, M., Rigby, A., Whybrow, P., & Simms, M. (2024). Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom. Ultrasound, https://doi.org/10.1177/1742271X231226302

Purpose: The purpose of this study was to evaluate if the use of micro-ultrasound can detect clinically significant prostate pathology when compared to histology obtained during a transperineal prostate biopsy. Methods: Patients suspected of having p... Read More about Evaluating the Role of Ultrasound in Prostate Cancer trial – phase 1: Early experience of micro-ultrasound in the United Kingdom.

The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease (2024)
Thesis
Nickolay, T. (2024). The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/4659878

This thesis investigates the utility of cardiopulmonary exercise testing (CPET) in assessing and managing patients with coronary artery disease (CAD), particularly focusing on the significance of oxygen pulse (O2Pulse) inflections as a marker for myo... Read More about The role of cardiopulmonary exercise testing for identifying possible silent myocardial ischaemia in people with coronary heart disease.

PC030. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop (2023)
Presentation / Conference Contribution
Hammond, A., Whittaker, J., Frere, T., & Stockbridge, C. (2023, December). PC030. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop. Poster presented at 5th Developing Excellence in Medical Education Conference (DEMEC): Education in the wider context – the patient, the team and the global community, Manchester

Background: Unconscious biases are beliefs, attitudes and stereotypes that can affect our understanding and decisions in a way that we're not aware of. If steps aren't taken to avoid acting on such biases, it can lead to unfair treatments and discri... Read More about PC030. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop.

Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes (2023)
Journal Article
Ravindhran, B., Lim, A. J., Kurian, T., Walshaw, J., Hitchman, L. H., Lathan, R., Smith, G. E., Carradice, D., Chetter, I. C., & Pymer, S. (in press). Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, https://doi.org/10.1016/j.ejvs.2023.11.040

Objective: This study aimed to explore the long term outcomes of patients with intermittent claudication (IC) who completed supervised exercise therapy (SET) vs. those who declined or prematurely discontinued SET, focusing on the incidence of chronic... Read More about Supervised Exercise Therapy for Intermittent Claudication: A Propensity Score Matched Analysis of Retrospective Data on Long Term Cardiovascular Outcomes.

Micro (and macro) aggressions: We all have a responsibility to ensure an open, supportive and inclusive culture (2023)
Presentation / Conference Contribution
Hammond, A. (2023, November). Micro (and macro) aggressions: We all have a responsibility to ensure an open, supportive and inclusive culture. Presented at Yorkshire and Humber School of Psychiatry Annual Conference, Harrogate

During this session you will: * Consider what is meant by the term ‘microaggression’ * Reflect on your own ‘culture’ * Consider what might impact your responding to a microaggression in everyday life * Be introduced to the Recognise, Choose, Act... Read More about Micro (and macro) aggressions: We all have a responsibility to ensure an open, supportive and inclusive culture.

Microaggressions & Bystander Training for Tutors and SPs: Providing a safe environment for Year 3 & 4 MB BS student to discuss and role play dealing with microaggressions personally or as a bystander in Communication Masterclasses (2023)
Presentation / Conference Contribution
Hammond, A., Frere, T., Stockbridge, C., & Whittaker, J. (2023, November). Microaggressions & Bystander Training for Tutors and SPs: Providing a safe environment for Year 3 & 4 MB BS student to discuss and role play dealing with microaggressions personally or as a bystander in Communication Masterclasses. Paper presented at Simulated Patients in Healthcare Education: A National Conference, Online

Presentation Objectives: To develop awareness of HYMS innovative Microaggression/Bystander Training delivered to our Communication Masterclass tutors & SPs to improve their skills and confidence in providing an opportunity for students to discuss... Read More about Microaggressions & Bystander Training for Tutors and SPs: Providing a safe environment for Year 3 & 4 MB BS student to discuss and role play dealing with microaggressions personally or as a bystander in Communication Masterclasses.

Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery (2023)
Thesis
Meddick-Dyson, S. (2023). Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4587991

Background Palliative and end-of-life care have important roles in intensive care units (ICUs) given symptom burden and rate of mortality in ICUs. However, we do not know how ICU-based palliative care interventions should be implemented. This system... Read More about Implementation lessons learnt when evaluating palliative care interventions in the intensive care unit: relationships between implementation determinants, strategies, and models of delivery.