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All Outputs (701)

Breathlessness limiting exertion in very old adults: findings from the Newcastle 85+ study (2023)
Journal Article
Johnson, M. J., Pitel, L., Currow, D. C., Forbes, C., Soyiri, I., & Robinson, L. (2023). Breathlessness limiting exertion in very old adults: findings from the Newcastle 85+ study. Age and ageing, 52(9), Article afad155. https://doi.org/10.1093/ageing/afad155

INTRODUCTION: Long-term breathlessness is more common with age. However, in the oldest old (>85years), little is known about the prevalence, or impact of breathlessness. We estimated breathlessness limiting exertion prevalence and explored (i) associ... Read More about Breathlessness limiting exertion in very old adults: findings from the Newcastle 85+ study.

Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., Harris, A. L., & Nikitenko, L. L. (2023). Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells. Cancer Research, 83(16_Supplement), A020-A020. https://doi.org/10.1158/1538-7445.kidney23-a020

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive kidney cancer, with high rates of metastasis and recurrence after cytoreductive nephrectomy. ccRCC can be treated with anti-angiogenic drugs, how... Read More about Abstract A020: Calcitonin receptor-like receptor is expressed in blood vessels in clear cell renal cell carcinoma and upregulated in endothelial cells co-cultured with tumor cells.

Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment (2023)
Presentation / Conference Contribution
Morfitt, M. A., Greenman, J., Maraveyas, A., & Nikitenko, L. L. (2023). Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment. Cancer Research, 83(16_Supplement), B001-B001. https://doi.org/10.1158/1538-7445.kidney23-b001

Introduction. Clear cell renal cell carcinoma (ccRCC) is a highly vascularized and clinically aggressive cancer. In the UK, there are around 9000 diagnoses and 3000 deaths annually. Targeted therapies that inhibit angiogenic regulators, such as bevac... Read More about Abstract B001: Calcitonin receptor-like receptor agonists induce p44/42 MAPK phosphorylation in VEGF-A-stimulated human blood endothelial cells after bevacizumab treatment.

Co-locating universal welfare advice in health settings for mothers and their families (2023)
Thesis
Reece, S. Co-locating universal welfare advice in health settings for mothers and their families. (Thesis). The University of Hull and the University of York. https://hull-repository.worktribe.com/output/4672312

Childhood deprivation is associated with poor health and social outcomes, limiting childhood development with long-lasting effects into adulthood. Welfare advice services improve financial security but access is often unequal for the most vulnerable.... Read More about Co-locating universal welfare advice in health settings for mothers and their families.

Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system (2023)
Thesis
Saldanha, P. A. C. B. D. S. Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4790706

Regulation of actomyosin-driven contraction is important for numerous cardiovascular cell functions, including smooth muscle tone, endothelial cell permeability and platelet shape change and spreading. These processes are primarily regulated by the p... Read More about Biochemical characterisation of the interaction of the myosin light chain phosphatase with the regulatory subunits of protein kinase A in cells of the circulatory system.

Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations: an integrated approach (2023)
Presentation / Conference Contribution
Lillicrap, M., & Hammond, A. (2023, June). Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations: an integrated approach. Presented at Facilitator Development Day - University of Cambridge School of Medicine, Cambridge

Objectives:
* To consider the challenges teachers/tutors (experts) might face in helping medical students (novices) develop their clinical reasoning skills
* To develop awareness of the role of faculty development in helping teachers/tutors deve... Read More about Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations: an integrated approach.

Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. (2023)
Presentation / Conference Contribution
Nikitenko, L. L., Manolis, D., O'Brien, D. P., Adekeye, A., Kessler, B. M., Collins, C., Kramer, H., Chang, D., & Maraveyas, A. Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer. Presented at The London Pancreas Workshop 2023, London, United Kingdom

In our EARLY DIAgnosis of PAncreatic Cancer (EARLY DIAPAC) study, we aim to analyse molecular changes or “signatures” associated with early stages of pancreatic carcinogenesis by using the combination of: (i) Label-Free Quantitative Proteomics (LFQP)... Read More about Quantitative proteomics of pancreatic cyst fluid for early diagnosis of cancer..

Workshop 21. Faculty Development - Equipping clinical tutors with the skills to assist students to develop their clinical reasoning in patient consultations (2023)
Presentation / Conference Contribution
Hammond, A., Gay, S., Matthan, J., Cooper, N., & Singh, M. (2023, May). Workshop 21. Faculty Development - Equipping clinical tutors with the skills to assist students to develop their clinical reasoning in patient consultations. Presented at 9th International Clinical Skills Conference, Prato, Italy

Workshop Objectives
To consider the particular challenges for clinical tutors (experts) in helping medical students (novices) develop their clinical reasoning skills.
To develop awareness of innovative approaches to faculty development to help tuto... Read More about Workshop 21. Faculty Development - Equipping clinical tutors with the skills to assist students to develop their clinical reasoning in patient consultations.

Oral 13. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop (2023)
Presentation / Conference Contribution
Hammond, A., Whittaker, J., Frere, T., & Stockbridge, C. (2023, May). Oral 13. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop. Presented at 9th International Clinical Skills Conference, Prato, Italy

Oral Presentation objectives
1) To develop awareness of our innovative workshop delivered to our Simulated Patients to increase their understanding of unconscious biases, how these might impact their work as Simulated Patients in our teaching and as... Read More about Oral 13. Unconscious Bias Training for our Simulated Patients: Showcasing a new and innovative workshop.

Workshop 47. The Future of consulting: Impact of changing practice on our cognitive load as experts and educators & insights into the novice perspective (2023)
Presentation / Conference Contribution
Hammond, A., & Ambrose, L. (2023, May). Workshop 47. The Future of consulting: Impact of changing practice on our cognitive load as experts and educators & insights into the novice perspective. Presented at 9th International Clinical Skills Conference, Prato, Italy

Objectives
1) To consider current & future impact of remote consulting & the covid pandemic on our cognitive load as clinical reasoning ‘experts’
2) To consider & reflect on the insights this has provided us as clinicians & educators into the stud... Read More about Workshop 47. The Future of consulting: Impact of changing practice on our cognitive load as experts and educators & insights into the novice perspective.

Bringing fictional characters to life: reflections on co-creating a comic book with members of the public (2023)
Journal Article
Cairns, J. M., Roberts, H., Al-Khafaji, G., & Kwater, M. (2023). Bringing fictional characters to life: reflections on co-creating a comic book with members of the public. Research Involvement and Engagement, 9(1), Article 28. https://doi.org/10.1186/s40900-023-00437-2

There are growing calls for cancer screening to become more personalised by considering a range of risk factors, rather than a one-size-fits-all, age-based approach. The aim of this public involvement was to co-create a comic book about bowel cancer... Read More about Bringing fictional characters to life: reflections on co-creating a comic book with members of the public.

Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site (2023)
Journal Article
Crooks, M. G., Crowther, L., Cummings, H., Cohen, J., Huang, C., Pitel, L., Pearson, M., Morice, A., Turgoose, J., Faruqi, S., Watt, M., Morris, T., & Xu, Y. (2023). Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site. ERJ Open Research, 9(3), Article 00685-2022. https://doi.org/10.1183/23120541.00685-2022

Aim: Short-acting β2-agonist (SABA) overuse adversely impacts asthma-related outcomes and the environment. The SABA rEductioN Through ImplemeNting Hull asthma guidELines (SENTINEL) programme aims to reduce SABA overuse through supported implementatio... Read More about Improving asthma care through implementation of the SENTINEL programme: findings from the pilot site.

Addressing delays to treatment in patients with chronic limb-threatening ischaemia (2023)
Thesis
Birmpili, P. Addressing delays to treatment in patients with chronic limb-threatening ischaemia. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4371299

Patients with CLTI often face long delays from referral to the vascular surgery service and hospital admission to revascularisation, and there is limited evidence on the effect of these delays on patient outcomes. This thesis aims to identify factors... Read More about Addressing delays to treatment in patients with chronic limb-threatening ischaemia.

Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure? (2023)
Journal Article
Cuthbert, J. J., Pellicori, P., Rigby, A. S., Abel, A. A., Kalvickbacka-Bennet, A., Shah, P., Kearsley, J. W., Kazmi, S., Cleland, J. G., & Clark, A. L. (2023). Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?. European Heart Journal - Quality of Care and Clinical Outcomes, 9(3), 281-292. https://doi.org/10.1093/ehjqcco/qcac035

Aims: We report associations between different formulae for estimating plasma volume status (PVS) and clinical and ultrasound markers of congestion in patients with chronic heart failure (CHF) enrolled in the Hull Lifelab registry. Methods and result... Read More about Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?.

Keynote - Integration of communication and clinical reasoning skills: Evolution of a medical school curriculum and reflections of a GP (2023)
Presentation / Conference Contribution
Hammond, A. (2023, March). Keynote - Integration of communication and clinical reasoning skills: Evolution of a medical school curriculum and reflections of a GP. Presented at UK Conference for Clinical Communication in Undergraduate Medical Education: Developing the clinical communication curriculum, Manchester

Conference programme:
Anna will discuss the evolution of the HYMS curriculum (including the explicit teaching of clinical reasoning, and integration of the communication and clinical reasoning curricula) and reflect on the impact of her own practice... Read More about Keynote - Integration of communication and clinical reasoning skills: Evolution of a medical school curriculum and reflections of a GP.

Faculty Development: Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations - an integrated approach (2023)
Presentation / Conference Contribution
Hammond, A., & Lillicrap, M. (2023, March). Faculty Development: Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations - an integrated approach. Presented at UK Council of Clinical Communication National Conference, Manchester

This interactive and multimedia workshop will showcase an approach that integrates the teaching of communication and clinical reasoning skills, through observation and discussion.

· To consider the challenges teachers/tutors (experts) might face i... Read More about Faculty Development: Equipping teachers with the skills to assist students to develop their clinical reasoning and communication skills in patient consultations - an integrated approach.

Creating a sport and exercise medicine undergraduate syllabus: a delphi study (2023)
Journal Article
Vishnubala, D., Iqbal, A., Marino, K., Pandya, T., Salman, D., Pringle, A., Nykjaer, C., Bazira, P., Eastwood, D., & Finn, G. (2023). Creating a sport and exercise medicine undergraduate syllabus: a delphi study. BMC Medical Education, 23(1), Article 179. https://doi.org/10.1186/s12909-023-04139-x

Background: Sport and Exercise Medicine (SEM) is a growing speciality in the United Kingdom (UK). This growth has not been replicated in SEM teaching at an undergraduate level and SEM-related topics in schools of medicine in the UK are under-represen... Read More about Creating a sport and exercise medicine undergraduate syllabus: a delphi study.

Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity (2023)
Journal Article
Iaconelli, A., Cuthbert, J., Kazmi, S., Maffia, P., Clark, A. L., Cleland, J. G., & Pellicori, P. (2023). Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity. Clinical Research in Cardiology, 112(8), 1077-1086. https://doi.org/10.1007/s00392-023-02178-4

Aims: A high, Doppler-derived, tricuspid regurgitation velocity (TRV) indicates pulmonary hypertension, which may contribute to right ventricular dysfunction and worsening tricuspid regurgitation leading to systemic venous congestion, reflected by an... Read More about Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity.

The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos (2023)
Thesis
Martin, F. The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4430667

Background: Blood-derived products are a growing area of therapeutic treatments for a diverse range of conditions, including hair loss, scarring, muscle injury, wounds, arthritis, and symptoms related to the menopause. Platelet-rich plasma (PRP) is o... Read More about The effect of platelet releasate on oocytes has a detrimental impact on early mammalian embryos.