All Outputs (664)

Increased frequency and suppressive activity of CD127low/- regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement (2013)
Journal Article
Drennan, S., Stafford, N. D., Greenman, J., & Green, V. (2013). Increased frequency and suppressive activity of CD127low/- regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement. Immunology, 140(3), 335-343. https://doi.org/10.1111/imm.12144

The presence of regulatory T (Treg) cells is thought to be an important mechanism by which head and neck squamous cell carcinoma (HNSCC) successfully evades the immune system. Using multicolour flow cytometry, the frequency and functional capacity of... Read More about Increased frequency and suppressive activity of CD127low/- regulatory T cells in the peripheral circulation of patients with head and neck squamous cell carcinoma are associated with advanced stage and nodal involvement.

Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units (2013)
Journal Article
Rigby, A., Atkin, S., Barth, J. H., & Kilpatrick, E. (2013). Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units. Clinical Chemistry, 59(10), 1457-1460. https://doi.org/10.1373/clinchem.2013.206334

BACKGROUND Many countries have implemented, or are considering, a change in hemoglobin A1c (Hb A1c) units from traditional percentage values [Diabetes Control and Complications Trial (DCCT)] to the new Système International d'Unités (SI) unit in mill... Read More about Glycemic Control in the 12 Months following a Change to SI Hemoglobin A1c Reporting Units.

Extension MRI is clinically useful in cervical myelopathy (2013)
Journal Article
Bartlett, R. J. V., Rigby, A. S., Joseph, J., Raman, A., Kunnacherry, A., & Hill, C. A. R. (2013). Extension MRI is clinically useful in cervical myelopathy. Neuroradiology, 55(9), 1081-1088. https://doi.org/10.1007/s00234-013-1208-z

Introduction: Cervical spine MRI with the neck in extension has been well described over the last 10 years, but its clinical value remains unknown. Methods: We performed extension imaging in 60 patients in whom the initial neutral study showed border... Read More about Extension MRI is clinically useful in cervical myelopathy.

P33. Optimising student experience: an innovative and integrated tutor support and development programme (2013)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2013, May). P33. Optimising student experience: an innovative and integrated tutor support and development programme. Poster presented at Fifth International Clinical Skills Conference: Clinical Skills Education - Building Bridges between Simulation and Practice, Prato, Italy

Background The curriculum of the five year MBBS course at HYMS is integrated and student–centred with regular clinical skills sessions throughout the first two years. The clinical skills tutors are practising clinicians who deliver their teaching rol... Read More about P33. Optimising student experience: an innovative and integrated tutor support and development programme.

P06. Clinical Reasoning in Medicine: Developing Students' metacognitive skills (2013)
Presentation / Conference Contribution
Hammond, A., & Henderson, J. (2013, May). P06. Clinical Reasoning in Medicine: Developing Students' metacognitive skills. Poster presented at 5th International Clinical Skills Conference - Clinical Skills Education: Building Bridges between Simulation and Practice, Prato, Italy

This poster outlines the introduction of formal Clinical Reasoning Skills sessions - initially a Student Selected Component (SSC) - as compulsory sessions in the core second year curriculum. Observations of 4th and 5th Year students’ performances i... Read More about P06. Clinical Reasoning in Medicine: Developing Students' metacognitive skills.

The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers (2013)
Journal Article
Kashuba, E., Bailey, J., Allsup, D., & Cawkwell, L. (2013). The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers, 18(4), 279-296. https://doi.org/10.3109/1354750x.2013.787544

The kinin–kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptide... Read More about The kinin–kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers.

Identifying individual psychosocial and adherence support needs in patients with psoriasis: a multinational two-stage qualitative and quantitative study (2013)
Journal Article
Bewley, A., Burrage, D. M., Ersser, S. J., Hansen, M., & Ward, C. (2014). Identifying individual psychosocial and adherence support needs in patients with psoriasis: a multinational two-stage qualitative and quantitative study. Journal of the European Academy of Dermatology and Venereology, 28(6), 763-770. https://doi.org/10.1111/jdv.12174

Background Psoriasis has a serious impact on patients' lives. However, adherence to medications is often poor, potentially compounding the burden of disease. Identifying patients who need support with psychosocial problems, or issues with adherence,... Read More about Identifying individual psychosocial and adherence support needs in patients with psoriasis: a multinational two-stage qualitative and quantitative study.

Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity (2013)
Journal Article
Kahal, H., Aburima, A., Ungvari, T., Rigby, A. S., Dawson, A. J., Coady, A. M., Vince, R. V., Ajjan, R. A., Kilpatrick, E. S., Naseem, K. M., & Atkin, S. L. (2013). Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity. Clinical Endocrinology, 79(2), 252-258. https://doi.org/10.1111/cen.12137

Introduction Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. Objective To assess if PCOS increases CV risk ind... Read More about Polycystic ovary syndrome has no independent effect on vascular, inflammatory or thrombotic markers when matched for obesity.

Comparison of 12-W versus 14-W endovenous laser ablation in the treatment of great saphenous varicose veins: 5-year outcomes from a randomized controlled trial (2013)
Journal Article
Samuel, N., Wallace, T., Carradice, D., Mazari, F. A., & Chetter, I. C. (2013). Comparison of 12-W versus 14-W endovenous laser ablation in the treatment of great saphenous varicose veins: 5-year outcomes from a randomized controlled trial. Vascular and endovascular surgery, 47(5), 346-352. https://doi.org/10.1177/1538574413487265

Introduction: Endovenous laser ablation (EVLA) has been demonstrated to be an effective treatment for lower limb varicose veins in the short and midterm results. This study reports the 5-year outcomes of EVLA technique at different power settings. Me... Read More about Comparison of 12-W versus 14-W endovenous laser ablation in the treatment of great saphenous varicose veins: 5-year outcomes from a randomized controlled trial.

Inspiring 'The Methodological Imagination': Using art and literature in social science methods teaching (2013)
Book Chapter
Seymour, J. (2013). Inspiring 'The Methodological Imagination': Using art and literature in social science methods teaching. In M. H. Jacobsen, M. S. Drake, & A. Petersen (Eds.), Imaginative Methodologies in the Social Sciences: Creativity, Poetics and Rhetoric in Social Research. Routledge. https://doi.org/10.4324/9781315587882

This chapter shows that how the use of art and literature in undergraduate research method modules can stimulate student involvement but perhaps more importantly lead to their greater intellectual understanding of the core principles of critically re... Read More about Inspiring 'The Methodological Imagination': Using art and literature in social science methods teaching.

Randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins (2013)
Journal Article
Samuel, N., Carradice, D., Wallace, T., Mekako, A., Hatfield, J., & Chetter, I. (2013). Randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins. Annals of Surgery, 257(3), 419-426. https://doi.org/10.1097/SLA.0b013e318275f4e4

Introduction: No randomized clinical trial comparing treatment options for small saphenous vein (SSV) incompetence exists, and there is no clear evidence that this axis behaves the same as the great saphenous vein after treatment. This means that the... Read More about Randomized clinical trial of endovenous laser ablation versus conventional surgery for small saphenous varicose veins.

Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure) (2013)
Journal Article
Damy, T., Ghio, S., Rigby, A. S., Hittinger, L., Jacobs, S., Leyva, F., Delgado, J. F., Daubert, J.-C., Gras, D., Tavazzi, L., & Cleland, J. G. (2013). Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure). Journal of the American College of Cardiology, 61(21), 2153-2160. https://doi.org/10.1016/j.jacc.2013.02.049

Objectives: The aim of this study was to investigate the impact of cardiac resynchronization therapy (CRT) on right ventricular (RV) function and the influence of RV dysfunction on the echocardiographic and clinical response to CRT among patients enr... Read More about Interplay between right ventricular function and cardiac resynchronization therapy : an analysis of the CARE-HF trial (cardiac resynchronization–heart failure).

Role of pre-operative multiple gated acquisition scanning in predicting long-term outcome in patients undergoing elective abdominal aortic aneurysm repair (2013)
Journal Article
Barakat, H. M., Shahin, Y., Khan, J. A., McCollum, P. T., & Chetter, I. C. (2013). Role of pre-operative multiple gated acquisition scanning in predicting long-term outcome in patients undergoing elective abdominal aortic aneurysm repair. World Journal of Surgery, 37(5), 1169-1173. https://doi.org/10.1007/s00268-013-1939-3

ObjectiveTo determine whether resting pre-operative left ventricular ejection fraction (LVEF) estimated by multiple gated acquisition scanning (MUGA) predicts long-term survival in patients undergoing elective abdominal aortic aneurysm (AAA) repair.... Read More about Role of pre-operative multiple gated acquisition scanning in predicting long-term outcome in patients undergoing elective abdominal aortic aneurysm repair.

A "Christmas tree" band for the treatment of arteriovenous dialysis access-related steal syndrome (2013)
Journal Article
Smith, G., Barnes, R., Green, L., Kuhan, G., & Chetter, I. C. (2013). A "Christmas tree" band for the treatment of arteriovenous dialysis access-related steal syndrome. Annals of vascular surgery, 27(2), 239.e9 - 239.e12. https://doi.org/10.1016/j.avsg.2012.10.004

Background Dialysis access steal syndrome (DASS) is an uncommon but often debilitating complication of dialysis access formation. We present a technical description of a novel arteriovenous fistula (AVF) banding technique for the treatment of DASS a... Read More about A "Christmas tree" band for the treatment of arteriovenous dialysis access-related steal syndrome.

Initial evidence of the reliability and validity of a three-dimensional body rating scale for the congenitally blind (2013)
Journal Article
Rocha Morgado, F. F., Ferreira, M. E. C., Campana, A. N., Rigby, A. S., & Tavares, M. D. C. G. (2013). Initial evidence of the reliability and validity of a three-dimensional body rating scale for the congenitally blind. Perceptual and Motor Skills, 116(1), 91-105. https://doi.org/10.2466/24.15.27.PMS.116.1.91-105

Research on body dissatisfaction has grown significantly. However, valid and reliable instruments for measuring body dissatisfaction in the congenitally blind have yet to be developed. In three studies, we report on development, test-retest reliabili... Read More about Initial evidence of the reliability and validity of a three-dimensional body rating scale for the congenitally blind.

Management of patients with chronic cough using a clinical protocol: A prospective observational study (2013)
Journal Article
Ojoo, O. C., Everett, C. F., Mulrennan, S. A., Faruqi, S., Kastelik, J. A., & Morice, A. H. (2013). Management of patients with chronic cough using a clinical protocol: A prospective observational study. Cough, 9(1), Article 2. https://doi.org/10.1186/1745-9974-9-2

Background and aims: Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily available. We wanted t... Read More about Management of patients with chronic cough using a clinical protocol: A prospective observational study.

Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697 (2013)
Journal Article
Agarwal, V., Hodgkinson, V. C., Eagle, G. L., Scaife, L., Lind, M. J., & Cawkwell, L. (2013). Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697. International Journal of Oncology, 42(3), 1088-1092. https://doi.org/10.3892/ijo.2013.1784

We have previously shown that specific COX-2 inhibitors, including DuP 697, have anti-proliferative effects on mesothelioma cells and potentiate the cytotoxicity of pemetrexed. Here, we used a novel proteomic approach to explore the mechanism of acti... Read More about Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.

Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design (2013)
Journal Article
Kotecha, D., Manzano, L., Altman, D. G., Krum, H., Erdem, G., Williams, N., …Beta-Blockers in Heart Failure Collaborative Group. (2013). Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design. Systematic reviews, 2(1), Article 7. https://doi.org/10.1186/2046-4053-2-7

The Beta-Blockers in Heart Failure Collaborative Group (BB-HF) was formed to obtain and analyze individual patient data from the major randomized controlled trials of beta-blockers in heart failure. Even though beta-blockers are an established treatm... Read More about Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design.

TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis (2013)
Journal Article
Zeng, B., Yuan, C., Yang, X., Atkin, S. L., & Xu, S.-Z. (2013). TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis. Current Cancer Drug Targets, 13(1), 103-116. https://doi.org/10.2174/156800913804486629

TRPC channels are Ca2+-permeable cationic channels controlling Ca2+ influx response to the activation of G protein-coupled receptors and protein tyrosine kinase pathways or the depletion of Ca2+ stores. Here we aimed to investigate whether TRPC can a... Read More about TRPC Channels and Their Splice Variants are Essential for Promoting Human Ovarian Cancer Cell Proliferation and Tumorigenesis.

PTEN protein expression in malignant pleural mesothelioma (2012)
Journal Article
Agarwal, V., Campbell, A., Beaumont, K. L., Cawkwell, L., & Lind, M. J. (2013). PTEN protein expression in malignant pleural mesothelioma. Tumor Biology, 34(2), 847-851. https://doi.org/10.1007/s13277-012-0615-9

Malignant pleural mesothelioma is associated with poor prognosis and despite recent advances in chemotherapy, the median survival is still approximately 12 months. Loss of phosphatase and tensin homolog (PTEN) protein expression may lead to constitut... Read More about PTEN protein expression in malignant pleural mesothelioma.