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Quantifying chronic cough: Objective versus subjective measurements (2010)
Journal Article
Faruqi, S., Thompson, R., Wright, C., Sheedy, W., & Morice, A. H. (2011). Quantifying chronic cough: Objective versus subjective measurements. Respirology : official journal of the Asian Pacific Society of Respirology, 16(2), 314-320. https://doi.org/10.1111/j.1440-1843.2010.01893.x

Background and objective: The assessment of chronic cough has been improved by the development of objective ambulatory cough monitoring systems and subjective quality of life questionnaires. Experimental induction of cough is a useful tool in the ass... Read More about Quantifying chronic cough: Objective versus subjective measurements.

Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy (2010)
Journal Article
Murray, A., Little, S. J., Stanley, P., Cawkwell, L., & Maraveyas, A. (2010). Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy. Oncology Reports, 24(4), 1049-1058. https://doi.org/10.3892/or-00000954

Angiogenesis inhibitors may enhance the effects of low dose (metronomic) chemotherapy. However, there is a wide range of novel angiogenesis inhibitors which must be tested in combinations with oral chemotherapy agents to assess the anti-endothelial a... Read More about Sorafenib enhances the in vitro anti-endothelial effects of low dose (metronomic) chemotherapy.

A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao (2010)
Journal Article
Rahman, M. A., Khan, J. A., Mazari, F. A. K., Mockford, K., McCollum, P. T., & Chetter, I. (2011). A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao. Annals of vascular surgery, 25(1), 32-38. https://doi.org/10.1016/j.avsg.2010.06.006

BackgroundA double-blind, randomized controlled trial was carried out to study the effects of statins on matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in areas of peak and low abdominal aortic aneurysm (A... Read More about A randomized placebo controlled trial of the effect of preoperative statin use on matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in areas of low and peak wall stress in patients undergoing elective open repair of abdominal ao.

Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication (2010)
Journal Article
Mockford, K. A., Mazari, F. A. K., Jordan, A. R., Vanicek, N., Chetter, I. C., & Coughlin, P. A. (2011). Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication. Annals of vascular surgery, 25(2), 182-190. https://doi.org/10.1016/j.avsg.2010.07.021

One-third of all elderly patients fall each year and impaired balance has been recognized as a specific risk factor. Intermittent claudication is common among the elderly population, affecting approximately 5% of the population over the age of 50. Th... Read More about Computerized dynamic posturography in the objective assessment of balance in patients with intermittent claudication.

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART) (2010)
Journal Article
Mazari, F. A. K., Mockford, K., Vanicek, N., Barnett, C., Khan, J. A., Brown, B., Smith, L., Polman, R. C., Hancock, A., & Chetter, I. C. (2010). Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART). Journal of vascular surgery, 52(6), 1564-1571. https://doi.org/10.1016/j.jvs.2010.07.006

Purpose: To compare articulated and nonarticulated early walking aids (EWAs) for clinical and quality-of-life outcomes in transtibial amputees. Methods: Patients undergoing lower limb amputation in a tertiary-care vascular surgical unit were screened... Read More about Hull early walking aid for rehabilitation of transtibial amputees - randomized controlled trial (HEART).

Physical activity preferences and type 2 diabetes: Exploring demographic, cognitive, and behavioral differences (2010)
Journal Article
Forbes, C. C., Plotnikoff, R. C., Courneya, K. S., & Boulé, N. G. (2010). Physical activity preferences and type 2 diabetes: Exploring demographic, cognitive, and behavioral differences. Diabetes Educator, 36(5), 801-815. https://doi.org/10.1177/0145721710378538

Purpose The purpose of this study was to examine physical activity counseling and program preferences in a sample of adults with type 2 diabetes. Specifically, the objectives were to determine physical activity preferences (objective 1), and whether... Read More about Physical activity preferences and type 2 diabetes: Exploring demographic, cognitive, and behavioral differences.

The role of blood pressure variability in the development of nephropathy in type 1 diabetes (2010)
Journal Article
Kilpatrick, E. S., Rigby, A. S., & Atkin, S. L. (2010). The role of blood pressure variability in the development of nephropathy in type 1 diabetes. Diabetes Care, 33(11), 2442-2447. https://doi.org/10.2337/dc10-1000

OBJECTIVE - Increases in blood pressure and visit-to-visit variability have both been found to independently increase the likelihood of cardiovascular events in nondiabetic individuals. This study has investigated whether each may also influence the... Read More about The role of blood pressure variability in the development of nephropathy in type 1 diabetes.

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species (2010)
Journal Article
Cheah, L.-T., Dou, Y. H., Seymour, A. M. L., Dyer, C. E., Haswell, S. J., Wadhawan, J. D., & Greenman, J. (2010). Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab on a chip, 10(20), 2720-2726. https://doi.org/10.1039/c004910g

A microfluidic device has been developed to maintain viable heart tissue samples in a biomimetic microenvironment. This device allows rat or human heart tissue to be studied under pseudo in vivo conditions. Effluent levels of lactate dehydrogenase an... Read More about Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species.

Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity (2010)
Journal Article
Carradice, D., Mazari, F. A., Mekako, A., Hatfield, J., Allgar, V., & Chetter, I. (2010). Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 40(3), 393-398. https://doi.org/10.1016/j.ejvs.2010.04.010

Aim: The durability of occlusion post endovenous laser therapy (EVLT) for varicose veins is linked to the magnitude of energy delivered to the vein and consequently increasing amounts of energy are employed. The aim of this study is to establish whet... Read More about Energy delivery during 810 nm endovenous laser ablation of varicose veins and post-procedural morbidity.

A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study (2010)
Journal Article
Barton, R., English, A., Nabb, S., Rigby, A. S., & Johnson, M. J. (2010). A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study. Lung Cancer, 70(3), 313-319. https://doi.org/10.1016/j.lungcan.2010.03.007

Background: Breathlessness remains a refractory symptom in malignant lung disease. Breathing training is an effective, non-pharmacological intervention but it is unclear how this should be delivered. This feasibility study aimed to assess recruitment... Read More about A randomised trial of high vs low intensity training in breathing techniques for breathless patients with malignant lung disease: A feasibility study.

Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status (2010)
Journal Article
Hodgkinson, V. C., Eagle, G. L., Drew, P. J., Lind, M. J., & Cawkwell, L. (2010). Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status. Cancer Letters, 294(1), 13-24. https://doi.org/10.1016/j.canlet.2010.01.036

This review describes and discusses the advantages and limitations of proteomic approaches in the identification of biomarkers associated with chemotherapy resistance. Both gel-based (two-dimensional polyacrylamide gel electrophoresis) and gel-free (... Read More about Biomarkers of chemotherapy resistance in breast cancer identified by proteomics: current status.

A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta (2009)
Journal Article
Bishop, N., Harrison, R., Ahmed, F., Shaw, N., Eastell, R., Campbell, M., Knowles, E., Hill, C., Hall, C., Chapman, S., Sprigg, A., & Rigby, A. (2010). A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta. Journal of Bone and Mineral Research, 25(1), 32-40. https://doi.org/10.1359/jbmr.090712

Moderate to severe osteogenesis imperfecta is associated with multiple fractures in childhood. There are no published data regarding the effects of third-generation bisphosphonates in these children. This randomized study investigated which of three... Read More about A randomized, controlled dose-ranging study of risedronate in children with moderate and severe osteogenesis imperfecta.

Acupuncture needling sensation: the neural correlates of deqi using fMRI (2009)
Journal Article
Asghar, A. U. R., Green, G., Lythgoe, M. F., Lewith, G., & MacPherson, H. (2010). Acupuncture needling sensation: the neural correlates of deqi using fMRI. Brain research, 1315, 111-118. https://doi.org/10.1016/j.brainres.2009.12.019

The needling sensation of deqi is considered by most acupuncturists to be an important component of acupuncture, yet neuroimaging research that investigates this needle sensation has been limited. In this study we have investigated the effect of deqi... Read More about Acupuncture needling sensation: the neural correlates of deqi using fMRI.

Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery (2009)
Journal Article
Mekako, A. I., Chetter, I. C., Coughlin, P. A., Hatfield, J., & McCollum, P. T. (2010). Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery. British journal of surgery, 97(1), 29-36. https://doi.org/10.1002/bjs.6849

Background: Wound infection rates of up to 16 per cent are reported following varicose vein surgery and the value of antibiotic prophylaxis in clean surgery remains unclear. Methods: Some 443 patients undergoing varicose vein surgery randomly receive... Read More about Randomized clinical trial of co-amoxiclav versus no antibiotic prophylaxis in varicose vein surgery.

TRPA1 agonists evoke coughing in guinea pig and human volunteers (2009)
Journal Article
Birrell, M. A., Belvisi, M. G., Grace, M., Sadofsky, L., Faruqi, S., Hele, D. J., Maher, S. A., Freund-Michel, V., & Morice, A. H. (2009). TRPA1 agonists evoke coughing in guinea pig and human volunteers. American Journal of Respiratory and Critical Care Medicine, 180(11), 1042-1047. https://doi.org/10.1164/rccm.200905-0665OC

Rationale: Cough is the most frequent reason for consultation with a family doctor, or with a general or respiratory physician. Treatment options are limited and one meta-analysis concluded that over-the-counter remedies are ineffective. There is als... Read More about TRPA1 agonists evoke coughing in guinea pig and human volunteers.

Lack of diastolic reserve in patients with heart failure and normal ejection fraction (2009)
Journal Article
Chattopadhyay, S., Alamgir, M. F., Nikitin, N. P., Rigby, A. S., Clark, A. L., & Cleland, J. G. F. (2010). Lack of diastolic reserve in patients with heart failure and normal ejection fraction. Circulation. Heart failure, 3(1), 35-43. https://doi.org/10.1161/CIRCHEARTFAILURE.108.824888

Background-The genesis of symptoms in patients with heart failure (HF) and normal ejection fraction (HFNEF) is unclear. Most investigations of HFNEF have focused on cardiac function at rest although most of these patients are breathless only on exerc... Read More about Lack of diastolic reserve in patients with heart failure and normal ejection fraction.