All Outputs (19)

Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT (2025)
Journal Article
Waldron, C.-A., Pallmann, P., Schoenbuchner, S., Harris, D., Brookes-Howell, L., Mateus, C., Bernatoniene, J., Cathie, K., Faust, S. N., Henley, J., Hinds, L., Hood, K., Huang, C., Jones, S., Kotecha, S., Milosevic, S., Nabwera, H., Patel, S., Paulus, S., Powell, C. V., …Carrol, E. D. (in press). Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT. Health Technology Assessment, 29(16), https://doi.org/10.3310/mbva3675

Background
Procalcitonin is a biomarker specific for bacterial infection, with a more rapid response than other commonly used biomarkers, such as C-reactive protein, but it is not routinely used in the National Health Service.

Objective
To deter... Read More about Effectiveness of biomarker-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection: the BATCH RCT.

Postoperative remote first care for financially and environmentally sustainable healthcare (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Carradice, D., Smith, G., Chetter, I., & Yiasewmidou, M. (2025). Postoperative remote first care for financially and environmentally sustainable healthcare. npj Digital Medicine, 8, Article 299. https://doi.org/10.1038/s41746-025-01585-3

This study aims to quantify the financial and environmental savings associated with remote follow up in patients undergoing lower limb arterial surgery. A prospective observational study evaluating financial cost(fC) and environmental cost(eC) of pos... Read More about Postoperative remote first care for financially and environmentally sustainable healthcare.

Optimising Digital Advance Care Planning Implementation in Palliative and End-of-life Care: A multi-phase mixed-methods national research programme and recommendations (2025)
Journal Article
Allsop, M. J., Birtwistle, J., Bennett, M. I., Bradshaw, A., Carder, P., Evans, C. J., Foy, R., Heavin, C., Hibbert, B., Martin, P. M., Relton, S. D., Richards, S. H., Twiddy, M., & Sleeman, K. E. (2025). Optimising Digital Advance Care Planning Implementation in Palliative and End-of-life Care: A multi-phase mixed-methods national research programme and recommendations. BMC medicine, 23, Article 291. https://doi.org/10.1186/s12916-025-04114-x

Background: Digital advance care planning (DACP) is increasingly used globally for patients with life-limiting conditions to support real-time documentation and the sharing of preferences for care. There has been low engagement with DACP systems, wit... Read More about Optimising Digital Advance Care Planning Implementation in Palliative and End-of-life Care: A multi-phase mixed-methods national research programme and recommendations.

Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial (2025)
Journal Article
Pollux, P. M., Surr, C., Cohen, J., Huang, C., Wolverson, E., Mountain, P., Clarke, R., Hawkesford-Webb, E., Winter, B., & Hudson, J. M. (2025). Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial. Pilot and Feasibility Studies, 11, Article 66. https://doi.org/10.1186/s40814-025-01637-1

Background: Many residents in care homes for older adults live with dementia. Understanding the unique profiles of cognitive impairments for each resident is important for person-centred care, yet information about specific cognitive problems is limi... Read More about Implementation of the Cognitive Daisy (COG-D) for improving care planning and delivery for residents with dementia in care homes: results of a feasibility randomised controlled trial.

Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery (2025)
Journal Article
Lathan, R., Daysley, H., Ravindhran, B., Lim, A., Cutteridge, J., Sidapra, M., Long, J., Hitchman, L., Beltran-Alvarez, P., Carradice, D., Smith, G., & Chetter, I. (2025). Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery. BJS Open, 9(3), Article zraf015. https://doi.org/10.1093/bjsopen/zraf015

Background
There is sparse evidence of the relationship between environmental and financial costs of surgical-site infection. Identifying areas of high-cost burden would enable key targets for clinical interventions to aid in achieving the UK nation... Read More about Environmental and financial cost of surgical-site infection by severity after lower limb vascular surgery.

Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses (2025)
Journal Article
Ravindhran, B., Parovic, M., Staniland, T., Howitt, A., Nazir, S., Lathan, R., Carradice, D., Smith, G., & Chetter, I. (in press). Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses. Journal of vascular access, https://doi.org/10.1177/11297298251332043

Background:
Clinical practice guidelines endorse arteriovenous fistulae (AVF) as the preferred form of vascular access. Despite recent advancements, concerns persist regarding variable AVF patency rates. This umbrella review aimed to evaluate and sy... Read More about Approaches to improve 12-month circuit primary patency and target lesion primary patency in arteriovenous fistulae: an umbrella review of systematic reviews and meta-analyses.

ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection (2025)
Journal Article
Lathan, R., Hitchman, L., Walshaw, J., Ravindhran, B., Sidapra, M., Lim, A., Long, J., Totty, J., Carradice, D., Smith, G., & Chetter, I. (2025). ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection. International wound journal, 22(4), Article e70234. https://doi.org/10.1111/iwj.70234

Background
Remote assessment of surgical site infection(SSI) lacks sensitivity for diagnosis of SSI but current evidence has not evaluated whether a combination of photographs and questionnaires improves diagnostic accuracy. This study aims to devel... Read More about ASSIST: Development of a simplified clinician-patient hybrid reporting outcome measure for remote diagnosis of surgical site infection.

A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol (2025)
Journal Article
Twiddy, M., Hitchman, L., Iglesias, C., Chetter, I. C., Russell, D., & Smith, G. (2025). A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol. International wound journal, 22(4), Article e70176. https://doi.org/10.1111/iwj.70176

The development of effective interventions for diabetes-related foot ulcers (DFU) healing is vital. This protocol outlines a pilot trial and qualitative study investigating ESWT in DFU healing. A pilot three arm placebo controlled double-blinded rand... Read More about A pilot three arm randomised controlled trial and qualitative study of extracorporeal shockwave therapy for diabetic foot ulcer healing (SOLEFUL): A study protocol.

Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial (2025)
Journal Article
Crooks, M. G., Wright, C., Hart, S., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Simpson, A., Huang, C., Sykes, D. L., & Johnson, M. (2025). Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial. BMJ Open Respiratory Research, 12(1), Article e002327. https://doi.org/10.1136/bmjresp-2024-002327

Introduction Breathlessness is common and impairs the quality of life of people with idiopathic pulmonary fibrosis (IPF) and non-IPF fibrotic interstitial lung diseases (ILD). We report the findings of a multicentre, fast-track (wait-list), mixed-met... Read More about Complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): a feasibility, wait-list design randomised controlled trial.

A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer (2025)
Journal Article
McKigney, N., Seligmann, J., Twiddy, M., Bach, S., Mohamed, F., Fearnhead, N., Brown, J., & Harji, D. (2025). A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer. Trials, 26(1), Article 98. https://doi.org/10.1186/s13063-025-08811-z

Background: The use of interventions such as major liver and lung resection, radiofrequency ablation and transarterial chemoembolization in the management of metastatic colorectal cancer (mCRC) is now relatively commonplace in clinical practice. Howe... Read More about A qualitative study to understand the challenges of conducting randomised controlled trials of complex interventions in metastatic colorectal cancer.

BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India (2025)
Journal Article
Clark, J., Salins, N., Sherigar, M., Williams, S., Pearson, M., Rao, S. R., Spathis, A., Bhat, R., Currow, D. C., Fraser, K., Simha, S., & Johnson, M. J. (2025). BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India. NPJ Primary Care Respiratory Medicine, 35(1), Article 13. https://doi.org/10.1038/s41533-025-00420-2

Breathlessness is highly prevalent in low and middle-income countries (LMICs). Low-cost, non-drug, breathlessness self-management interventions are effective in high-income countries. However, health beliefs influence acceptability and have not been... Read More about BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India.

Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe) (2025)
Journal Article
Raut, S., Hales, A., Twiddy, M., Dixon, L., Ngaage, D., Yates, D., Danjoux, G., & Ingle, L. (2025). Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe). PLoS ONE, 20(3 March), Article e0307341. https://doi.org/10.1371/journal.pone.0307341

Background The concept of “prehabilitation,” or optimising individual physical and mental wellbeing prior to surgery is well established in cancer and orthopaedic populations. However, amongst the cardiac surgery population, the concept is relatively... Read More about Multimodal prehabilitation in people awaiting acute inpatient cardiac surgery: Study protocol for a pilot feasibility trial (PreP-ACe).

Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase (2025)
Journal Article
Ekström, M., Alameri, F., Chang, S., Ferreira, D., Johnson, M. J., & Currow, D. C. (in press). Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2025.02.020

Context: Morphine to treat severe chronic breathlessness might increase adverse events (AEs). Objectives: We aimed to evaluate the risk of AEs in relation to dose, duration and titration phase of regular, low-dose sustained-release (SR) oral morphine... Read More about Harms of Morphine for Chronic Breathlessness in Relation to Dose, Duration and Titration Phase.

ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions (2025)
Journal Article
Luckett, T., Swan, F., Clark, J., Roberts, M., Pearson, M., Hutchinson, A., Currow, D., Kochovska, S., Crooks, M., Smith, T., & Johnson, M. (2025). ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions. European respiratory journal, 65(2), Article 2402244. https://doi.org/10.1183/13993003.02244-2024

NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy (2025)
Journal Article
Croft, J., Ainsworth, G., Corrigan, N., Gordon, K., Perry, A., Twiddy, M., Strachan, M., Wadsley, J., Mehanna, H., Sharma, N., Glenister, E., Stocken, D. D., & Balasubramanian, S. P. P. (2025). NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy. BMJ open, 15(1), Article e092422. https://doi.org/10.1136/bmjopen-2024-092422

Introduction Postsurgical hypoparathyroidism (PoSH) is an iatrogenic condition that occurs as a complication of several different procedures with thyroid surgery being the most common. PoSH has significant short- and long-term morbidities. The volume... Read More about NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled trial protocol in patients undergoing a total or completion thyroidectomy.

"I'm living in a 'no' world now…"- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symptom in an older, frail community-based population (2025)
Journal Article
Elliott-Button, H., Johnson, M. J., Hutchinson, A., Currow, D. C., & Clark, J. (2025). "I'm living in a 'no' world now…"- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symptom in an older, frail community-based population. NPJ Primary Care Respiratory Medicine, 35(1), Article 5. https://doi.org/10.1038/s41533-024-00409-3

Chronic breathlessness is a debilitating symptom with detrimental impact on individuals and carers. However, little is known about the experiences of community-dwelling, frail, older adults living with chronic breathlessness. To explore, (i) the psyc... Read More about "I'm living in a 'no' world now…"- A qualitative study of the widespread impact of living with chronic breathlessness, and experiences of identification and assessment of this symptom in an older, frail community-based population.

Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial (2025)
Journal Article
Waldron, C. A., Pallmann, P., Schoenbuchner, S., Harris, D., Brookes-Howell, L., Mateus, C., Bernatoniene, J., Cathie, K., Faust, S. N., Hinds, L., Hood, K., Huang, C., Jones, S., Kotecha, S., Nabwera, H. M., Patel, S., Paulus, S. C., Powell, C. V. E., Preston, J., Xiang, H., …on behalf of the BATCH Trial Team. (2025). Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial. The Lancet Child & Adolescent Health, 9(2), 121-130. https://doi.org/10.1016/S2352-4642%2824%2900306-7

Background: Procalcitonin is a rapid response biomarker specific for bacterial infection, which is not routinely used in the UK National Health Service. We aimed to assess whether using a procalcitonin-guided algorithm would safely reduce the duratio... Read More about Procalcitonin-guided duration of antibiotic treatment in children hospitalised with confirmed or suspected bacterial infection in the UK (BATCH): a pragmatic, multicentre, open-label, two-arm, individually randomised, controlled trial.

Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients (2025)
Journal Article
den Brinker, A. C., Ouweltjes, O., Rietman, R., Thackray-Nocera, S., Crooks, M. G., & Morice, A. H. (2025). Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients. Sensors, 25(2), Article 404. https://doi.org/10.3390/s25020404

Coughing is a symptom of many respiratory diseases. An increased amount of coughs may signal an (upcoming) health issue, while a decreasing amount of coughs may indicate an improved health status. The presence of a cough can be identified by a cough... Read More about Nighttime Cough Characteristics in Chronic Obstructive Pulmonary Disease Patients.

Can Passive Cough Monitoring Predict COPD Exacerbations? (2025)
Journal Article
Morice, A. H., den Brinker, A. C., Crooks, M., Thackray-Nocera, S., Ouweltjes, O., & Rietman, R. (2025). Can Passive Cough Monitoring Predict COPD Exacerbations?. COPD: Journal of Chronic Obstructive Pulmonary Disease, 22(1), Article 2487909. https://doi.org/10.1080/15412555.2025.2487909

Purpose: Validation of an alert mechanism for COPD exacerbations based on coughing detected by a stationary unobtrusive nighttime monitor. Methods: This prospective double-blind longitudinal study of cough monitoring included 40 chronic obstructive p... Read More about Can Passive Cough Monitoring Predict COPD Exacerbations?.