All Outputs (354)

Prevalence and risk factors of breathlessness across Canada: A national retrospective cohort study in home care and nursing home populations (2020)
Journal Article
Seow, H., Dutta, P., Johnson, M. J., McMillan, K., Guthrie, D. M., Costa, A., & Currow, D. C. (in press). Prevalence and risk factors of breathlessness across Canada: A national retrospective cohort study in home care and nursing home populations. Journal of pain and symptom management, https://doi.org/10.1016/j.jpainsymman.2020.11.034

© 2020 American Academy of Hospice and Palliative Medicine Context: Breathlessness is a symptom associated with poor clinical outcomes and prognosis. Little is known about its long-term trends and associations with social factors including decline in... Read More about Prevalence and risk factors of breathlessness across Canada: A national retrospective cohort study in home care and nursing home populations.

Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial (2020)
Journal Article
Monk, P. D., Marsden, R. J., Tear, V. J., Brookes, J., Batten, T. N., Mankowski, M., Gabbay, F. J., Davies, D. E., Holgate, S. T., Ho, L. P., Clark, T., Djukanovic, R., Wilkinson, T. M. A., Crooks, M. G., Dosanjh, D. P., Siddiqui, S., Rahman, N. M., Smith, J. A., Horsley, A., Harrison, T. W., …Rodrigues, P. M. (2021). Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial. The lancet. Respiratory medicine, 9(2), 196-206. https://doi.org/10.1016/S2213-2600%2820%2930511-7

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries a substantial risk of severe and prolonged illness; treatment options are currently limited. We assessed the efficacy and safety of inhaled nebulised interfero... Read More about Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial.

Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication (2020)
Journal Article
Pymer, S., Ibeggazene, S., Palmer, J., Smith, G. E., Carroll, S., Ingle, L., Harwood, A., & Chetter, I. C. (2021). Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication. Journal of Cardiopulmonary Rehabilitation and Prevention, 41(3), 188-193. https://doi.org/10.1097/HCR.0000000000000551

Considering the Feasibility, Tolerability and Safety of High-Intensity Interval Training as a Novel Treatment for Patients with Intermittent Claudication. Structured Abstract Purpose: This study assessed the feasibility, tolerability, safety and... Read More about Considering the feasibility, tolerability and safety of high intensity interval training as a novel treatment for patients with intermittent claudication.

Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis (2020)
Journal Article
Danopoulos, E., Jenner, L., Twiddy, M., & Rotchell, J. M. (2020). Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis. SN Applied Sciences, 2(12), Article 1950. https://doi.org/10.1007/s42452-020-03749-0

Microplastics (MPs) are an emerging contaminant ubiquitous in the environment. There is growing concern regarding potential human health effects, a major human exposure route being dietary uptake. We have undertaken a systematic review (SR) and meta-... Read More about Microplastic contamination of salt intended for human consumption: a systematic review and meta-analysis.

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries (2020)
Journal Article
GBD 2019 Demographics Collaborators, & Soyiri, I. (2020). Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries. Lancet, 396(10258), 1160-1203. https://doi.org/10.1016/S0140-6736%2820%2930977-6

Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors... Read More about Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries.

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 (2020)
Journal Article
Abbafati, C., Abbas, K. M., Abbasi, M., Abbasifard, M., Abbasi-Kangevari, M., Abbastabar, H., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abedi, A., Abedi, P., Abegaz, K. H., Abolhassani, H., Abosetugn, A. E., Aboyans, V., Abrams, E. M., Abreu, L. G., Abrigo, M. R., Abu Haimed, A. K., …Soyiri, I. (2020). Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396(10258), 1204-1222. https://doi.org/10.1016/S0140-6736%2820%2930925-9

Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, In... Read More about Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 (2020)
Journal Article
Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., Abegaz, K. H., Abolhassani, H., Aboyans, V., Abreu, L. G., Abrigo, M. R., Abualhasan, A., Abu-Raddad, L. J., Abushouk, A. I., Adabi, M., Adekanmbi, V., Adeoye, A. M., Adetokunboh, O. O., Adham, D., …Soyiri, I. (2020). Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet, 396(10258), 1223-1249. https://doi.org/10.1016/S0140-6736%2820%2930752-2

Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequa... Read More about Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.

Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services (2020)
Journal Article
Hess, S., Meads, D., Twiddy, M., Mason, S., Czoski-Murray, C., & Minton, J. (2021). Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services. Journal of Choice Modelling, 38, Article 100252. https://doi.org/10.1016/j.jocm.2020.100252

Choice modelling techniques have established themselves as a key analysis tool in health economics and have been used to understand patient and practitioner preferences across a wide variety of settings. A key interest in recent years has been the in... Read More about Characterising heterogeneity and the role of attitudes in patient preferences: a case study in preferences for outpatient parenteral intravenous antimicrobial therapy (OPAT) services.

Azithromycin for sarcoidosis cough: an open label exploratory clinical trial (2020)
Journal Article
Fraser, S. D., Thackray-Nocera, S., Shepherd, M., Flockton, R., Wright, C., Sheedy, W., Brindle, K., Morice, A. H., Kaye, P. M., Crooks, M. G., & Hart, S. P. (2020). Azithromycin for sarcoidosis cough: an open label exploratory clinical trial. ERJ Open Research, 6(4), Article 00534. https://doi.org/10.1183/23120541.00534-2020

Background: Chronic cough is a distressing symptom for many people with pulmonary sarcoidosis. Continuous treatment with a macrolide antibiotic may improve cough. We aimed to assess the potential efficacy of azithromycin in patients with sarcoidosis... Read More about Azithromycin for sarcoidosis cough: an open label exploratory clinical trial.

Morphine for the symptomatic reduction of chronic breathlessness: the case for controlled release (2020)
Journal Article
Currow, D. C., Kochovska, S., Ferreira, D., & Johnson, M. (2020). Morphine for the symptomatic reduction of chronic breathlessness: the case for controlled release. Current opinion in supportive and palliative care, 14(3), 177-181. https://doi.org/10.1097/SPC.0000000000000520

Purpose of Review: Clinicians who seek to reduce the symptomatic burden of chronic breathlessness by initiating regular low dose morphine have the choice of immediate or sustained release formulations - which will be better for this often frail popu... Read More about Morphine for the symptomatic reduction of chronic breathlessness: the case for controlled release.

Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. (2020)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Elizabeth Harwood, A., Ingle, L., Huang, C., & Chetter, I. C. (2020). Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease. Cochrane Database of Systematic Reviews, Article CD013407. https://doi.org/10.1002/14651858.CD013407.pub2

Background Lower limb peripheral arterial disease (PAD) is a type of cardiovascular disease where the blood vessels that carry the blood to the legs are hardened and narrowed. The most severe manifestation of PAD is critical limb ischaemia (CLI). Th... Read More about Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease..

Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (Review) (2020)
Journal Article
Palmer, J., Pymer, S., Smith, G. E., Harwood, A., Ingle, L., Huang, C., & Chetter, I. C. (2020). Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (Review). The Cochrane database of systematic reviews, 2020(9), Article CD013407. https://doi.org/10.1002/14651858.CD013407.pub2

Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. Background: Lower limb peripheral arterial disease (PAD) is a type of cardiovascular disease where the blood vessels that carry the blood to the legs are hardened and... Read More about Presurgery exercise-based conditioning interventions (prehabilitation) in adults undergoing lower limb surgery for peripheral arterial disease (Review).

Alert system design based on experimental findings from long-term unobtrusive monitoring in COPD (2020)
Journal Article
den Brinker, A. C., van Dinther, R., Crooks, M. G., Thackray-Nocera, S., & Morice, A. H. (2021). Alert system design based on experimental findings from long-term unobtrusive monitoring in COPD. Biomedical Signal Processing and Control, 63, Article 102205. https://doi.org/10.1016/j.bspc.2020.102205

An observational study using a cough count monitor was executed in the home of 30 patients with Chronic Obstructive Pulmonary Disease (COPD). The monitoring system was unobtrusive, allowing long-term monitoring. This paper illustrates the cough count... Read More about Alert system design based on experimental findings from long-term unobtrusive monitoring in COPD.

Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma? (2020)
Journal Article
Faruqi, S., Sykes, D. L., Crooks, M. G., Brindle, K., Thompson, J., & Morice, A. H. (2020). Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma?. Lung, 198(5), 767-770. https://doi.org/10.1007/s00408-020-00391-w

© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Cough is an important symptom of asthma. The objective assessment of chronic cough has been enhanced by the development of ambulatory cough monitoring systems. Mepolizumab has bee... Read More about Objective Assessment of Cough: An Early Marker of Response to Biological Therapies in Asthma?.

A randomised clinical trial of ultrasound guided cannulation of difficult fistulae for dialysis access (2020)
Journal Article
Eves, J., Cai, P., Latham, R., Leung, C., Carradice, D., Chetter, I., & Smith, G. (in press). A randomised clinical trial of ultrasound guided cannulation of difficult fistulae for dialysis access. The journal of vascular access, https://doi.org/10.1177/1129729820954725

Background: Arteriovenous fistulae (AVF) are preferred for dialysis access but require accurate cannulation for effective dialysis. Evidence supports improvements in cannulation and complication rates using ultrasound guidance (USG) in cannulating ot... Read More about A randomised clinical trial of ultrasound guided cannulation of difficult fistulae for dialysis access.

Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship (2020)
Journal Article
Phillips, T., Huang, C., Roberts, E., & Drummond, C. (2021). Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship. Alcohol and Alcoholism, 56(1), 28-33. https://doi.org/10.1093/alcalc/agaa086

© The Author(s) 2020. Medical Council on Alcohol and Oxford University Press. AIMS: We assessed the relationship between specialist and non-specialist admissions for alcohol withdrawal since the introduction of the UK government Health and Social Car... Read More about Specialist alcohol inpatient treatment admissions and non-specialist hospital admissions for alcohol withdrawal in England: an inverse relationship.

Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search (2020)
Journal Article
Coleman, S., Wright, J. M., Nixon, J., Schoonhoven, L., Twiddy, M., & Greenhalgh, J. (2020). Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search. BMC Medical Research Methodology, 20(1), 217. https://doi.org/10.1186/s12874-020-01084-x

BACKGROUND: Realist methodologies are increasingly being used to evaluate complex interventions in health and social care. Programme theory (ideas and assumptions of how a particular intervention works) development is the first step in a realist eval... Read More about Searching for Programme Theories for a realist evaluation: A case study comparing an academic database search and a simple Google search.

Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study (2020)
Journal Article
James, S. L., Bertolacci, G. J., Castle, C. D., Dingels, Z. V., Fox, J. T., Hamilton, E. B., Roberts, N. L., Sylte, D. O., Henry, N. J., LeGrand, K. E., Banerjee, S. K., Abushouk, A. I., Adebayo, O. M., Adsuar, J. C., Advani, S. M., Alghnam, S. A., Almasri, N. A., Badiye, A. D., Bennett, D. A., Yaw Appiah, S. C., …Vos, T. (2020). Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study. Injury Prevention, 26, i125-i153. https://doi.org/10.1136/injuryprev-2019-043531

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. BACKGROUND: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disabili... Read More about Estimating global injuries morbidity and mortality: methods and data used in the Global Burden of Disease 2017 study.

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17 (2020)
Journal Article
Reiner, R. C., Local Burden of Disease WaSH Collaborators, & Soyiri, I. (2020). Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17. The Lancet global health, 8(9), e1162-e1185. https://doi.org/10.1016/S2214-109X%2820%2930278-3

Background Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolutio... Read More about Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17.

Activities forgone because of chronic breathlessness: a cross-sectional, population prevalence study (2020)
Journal Article
Kochovska, S., Chang, S., Morgan, D. D., Ferreira, D., Sidhu, M., Saleh Moussa, R., Johnson, M. J., Ekström, M., & Currow, D. C. (2020). Activities forgone because of chronic breathlessness: a cross-sectional, population prevalence study. Palliative Medicine Reports, 1(1), 166-170. https://doi.org/10.1089/pmr.2020.0083

Background Chronic breathlessness is a prevalent, disabling syndrome affecting many people for years. Identifying the impact of chronic breathlessness on people’s activities in the general population is pivotal for designing symptom management strat... Read More about Activities forgone because of chronic breathlessness: a cross-sectional, population prevalence study.