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Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation (2016)
Journal Article
Segrott, J., Rothwell, H., Pignatelli, I., Playle, R., Hewitt, G., Huang, C., Murphy, S., Hickman, M., Reed, H., & Moore, L. (2016). Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation. Health Education, 116(4), 410-431. https://doi.org/10.1108/HE-01-2015-0005

Purpose – Involvement of parents/carers may increase effectiveness of primary school-based alcohol-misuse prevention projects through strengthening family-based protective factors, but rates of parental engagement are typically low. This paper report... Read More about Exploratory trial of a school-based alcohol prevention intervention with a family component: Implications for implementation.

Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review (2016)
Journal Article
Luckett, T., Disler, R., Hosie, A., Johnson, M., Davidson, P., Currow, D., Sumah, A., & Phillips, J. (2016). Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review. NPJ Primary Care Respiratory Medicine, 26(1), Article ARTN 16025. https://doi.org/10.1038/npjpcrm.2016.25

Chronic breathlessness is a common, burdensome and distressing symptom in many advanced chronic illnesses. Self-management strategies are essential to optimise treatment, daily functioning and emotional coping. People with chronic illness commonly se... Read More about Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review.

Building a recruitment database for asthma trials: a conceptual framework for the creation of the UK Database of Asthma Research Volunteers (2016)
Journal Article
Nwaru, B. I., Soyiri, I. N., Simpson, C. R., Griffiths, C., & Sheikh, A. (2016). Building a recruitment database for asthma trials: a conceptual framework for the creation of the UK Database of Asthma Research Volunteers. Trials, 17(1), Article 264. https://doi.org/10.1186/s13063-016-1381-6

Background
Randomised clinical trials are the ‘gold standard’ for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a concep... Read More about Building a recruitment database for asthma trials: a conceptual framework for the creation of the UK Database of Asthma Research Volunteers.

A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication (2016)
Journal Article
Harwood, A., Smith, G. E., Cayton, T., Broadbent, E., & Chetter, I. C. (2016). A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication. Annals of vascular surgery, 34, 280-289. https://doi.org/10.1016/j.avsg.2016.02.009

Background Intermittent claudication (IC) is a common and debilitating symptom of peripheral arterial disease and is associated with a significant reduction in a sufferer's quality of life. Guidelines recommend a supervised exercise program (SEP) as... Read More about A Systematic Review of the Uptake and Adherence Rates to Supervised Exercise Programs in Patients with Intermittent Claudication.

A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: The ChildRen with eczema, antibiotic management (CREAM) study (2016)
Journal Article
Francis, N. A., Ridd, M. J., Thomas-Jones, E., Shepherd, V., Butler, C. C., Hood, K., Huang, C., Addison, K., Longo, M., Marwick, C., Wootton, M., Howe, R., Roberts, A., Haq, M. I.-U., Madhok, V., Sullivan, F., & on behalf of the CREAM team. (2016). A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: The ChildRen with eczema, antibiotic management (CREAM) study. Health Technology Assessment, 20(19), 1-84. https://doi.org/10.3310/hta20190

Background
Secondary skin infection is common during eczema exacerbations and many children are treated with antibiotics when this is suspected, although there is little high-quality evidence to justify this practice.

Objective
To determine the... Read More about A randomised placebo-controlled trial of oral and topical antibiotics for children with clinically infected eczema in the community: The ChildRen with eczema, antibiotic management (CREAM) study.

Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials (2016)
Journal Article
Temel, J. S., Abernethy, A. P., Currow, D. C., Friend, J., Duus, E. M., Yan, Y., & Fearon, K. C. (2016). Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. The lancet oncology, 17(4), 519-531. https://doi.org/10.1016/S1470-2045%2815%2900558-6

© 2016 Elsevier Ltd Background Patients with advanced cancer frequently experience anorexia and cachexia, which are associated with reduced food intake, altered body composition, and decreased functionality. We assessed anamorelin, a novel ghrelin-re... Read More about Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials.

A mixed-methods, randomized controlled, feasibility trial to inform the design of a phase 3 trial to test the effect of the hand-held fan on physical activity and carer anxiety in patients with refractory breathlessness (2016)
Journal Article
Johnson, M. J., Booth, S., Currow, D. C., Lam, L. T., & Phillips, J. L. (2016). A mixed-methods, randomized controlled, feasibility trial to inform the design of a phase 3 trial to test the effect of the hand-held fan on physical activity and carer anxiety in patients with refractory breathlessness. Journal of pain and symptom management, 51(5), 807-815. https://doi.org/10.1016/j.jpainsymman.2015.11.026

Context The handheld fan is an inexpensive and safe way to provide facial airflow, which may reduce the sensation of chronic refractory breathlessness, a frequently encountered symptom. Objectives To test the feasibility of developing an adequately p... Read More about A mixed-methods, randomized controlled, feasibility trial to inform the design of a phase 3 trial to test the effect of the hand-held fan on physical activity and carer anxiety in patients with refractory breathlessness.

Extreme low-lying carotid bifurcations (2016)
Journal Article
Harwood, A. E., Leung, C. C. M., Smith, G. E., & Chetter, I. C. (2016). Extreme low-lying carotid bifurcations. Vascular Medicine, 21(4), 394-395. https://doi.org/10.1177/1358863X15627208

A 52-year-old male with no past medical history was referred to the transient ischaemic attack (TIA) clinic following an event at home. The transient symptoms were of an inability to move his left arm and leg for a period of approximately 15 minutes.... Read More about Extreme low-lying carotid bifurcations.

The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease (2016)
Journal Article
Boland, J. W., Reigada, C., Yorke, J., Hart, S. P., Bajwah, S., Ross, J., Wells, A., Papadopoulos, A., Currow, D. C., Grande, G., Macleod, U., & Johnson, M. J. (2016). The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease. Journal of palliative medicine, 19(5), 549-555. https://doi.org/10.1089/jpm.2015.0355

Background: Irrreversible interstitial lung disease (ILD) is associated with high morbidity and mortality. Palliative care needs of patients and caregivers are not routinely assessed; there is no tool to identify needs and triage support in clinical... Read More about The adaptation, face, and content validation of a needs assessment tool: progressive disease for people with interstitial lung disease.

Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey (2016)
Journal Article
Johnson, M. J., Allgar, V., Macleod, U., Jones, A., Oliver, S., & Currow, D. (2016). Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey. PLoS ONE, 11(1), e0146960. https://doi.org/10.1371/journal.pone.0146960

Background Family caregivers provide significant care at the end of life. We aimed to describe caregiver characteristics, and of those unwilling to repeat this role under the same circumstances. Methods Observational study of adults in private househ... Read More about Family caregivers who would be unwilling to provide care at the end of life again: findings from the Health Survey for England population survey.

The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes (2016)
Journal Article
Smith, G. E., Barnes, R., Chetter, I. C., Barnes, R., & Fagan, M. (2016). The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes. Annals of vascular surgery, 32, 9-14. https://doi.org/10.1016/j.avsg.2015.11.002

© 2016 Elsevier Inc. Background Arteriovenous fistulae (AVFs) are the preferred access for hemodialysis but suffer a high early failure rate. The aim of this study was to determine how venous distensibility, as measured in vitro, relates to early out... Read More about The Impact of Vein Mechanical Compliance on Arteriovenous Fistula Outcomes.

Breathlessness in the elderly during the last year of life sufficient to restrict activity (2016)
Journal Article
Johnson, M. J., Bland, J. M., Gahbauer, E. A., Ekström, M., Sinnarajah, A., Gill, T. M., & Currow, D. (2016). Breathlessness in the elderly during the last year of life sufficient to restrict activity. Journal of the American Geriatrics Society, 64(1), 73-80. https://doi.org/10.1111/jgs.13865

OBJECTIVES: Breathlessness is prevalent in older people. Symptom control at the end of life is important. This study investigated relationships between age, clinical characteristics and breathlessness sufficient to have people spend at least one half... Read More about Breathlessness in the elderly during the last year of life sufficient to restrict activity.

TOUCAN: A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin. (2016)
Journal Article
Jones, R. J., Crabb, S. J., Chester, J. D., Elliott, T., Huddart, R. A., Birtle, A. J., Evans, L., Lester, J. F., Huang, C., Casbard, A. C., Madden, T.-A., & Griffiths, G. (2016). TOUCAN: A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin. Journal of Clinical Oncology, 34(2_suppl), 448-448. https://doi.org/10.1200/jco.2016.34.2_suppl.448

Background: Whilst cisplatin combination therapy remains the standard of care for patients with advanced urothelial cancers, many patients are unsuitable for cisplatin and go on to receive carboplatin combination therapy. Although responses are frequ... Read More about TOUCAN: A randomised phase II trial of carboplatin and gemcitabine +/- vandetanib in first line treatment of advanced urothelial cell cancer in patients who are not suitable to receive cisplatin..

Does more education always lead to better health? Evidence from rural malaysia (2015)
Journal Article
Leeves, G., & Soyiri, I. (2015). Does more education always lead to better health? Evidence from rural malaysia. Biomed research international, 2015, 1-9. https://doi.org/10.1155/2015/539212

Background. Education is usually associated with improvement in health; there is evidence that this may not be the case if education
is not fully utilised at work. This study examines the relationship between education level, occupation, and health o... Read More about Does more education always lead to better health? Evidence from rural malaysia.

Searching for health information online for my child: A perspective from South East Asia (2015)
Presentation / Conference Contribution
Inthiran, A., & Soyiri, I. Searching for health information online for my child: A perspective from South East Asia

Research studies investigating online health information searching behavior are abundant. While there is research pertaining to the online health information seeking behavior of parents in developed countries, similar information for countries with d... Read More about Searching for health information online for my child: A perspective from South East Asia.

Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study (2015)
Journal Article
Martins, R. T., Currow, D., Abernethy, A. P., Johnson, M. J., Toson, B., & Eckert, D. J. (2016). Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study. Respirology : official journal of the Asian Pacific Society of Respirology, 21(2), 386-391. https://doi.org/10.1111/resp.12681

© 2015 Asian Pacific Society of Respirology. Background and objective The management of chronic refractory breathlessness is one of the indications for regular low-dose (≤30 mg/24 h) oral sustained release morphine. Morphine may disrupt sleep in some... Read More about Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness : a hypothesis generating study.

Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study (2015)
Journal Article
Ferreira, D. H., Silva, J. P., Quinn, S., Abernethy, A. P., Johnson, M. J., Oxberry, S. G., & Currow, D. C. (2016). Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study. Journal of pain and symptom management, 51(2), 247-254. https://doi.org/10.1016/j.jpainsymman.2015.10.005

Context Patients’ preference for morphine therapy has received little attention in the setting of chronic refractory breathlessness. However, this is one important factor in considering longer term therapy. Objectives The aim of this secondary analys... Read More about Blinded patient preference for morphine compared to placebo in the setting of chronic refractory breathlessness – an exploratory study.

Infection in prosthetic material (2015)
Journal Article
Smith, G., & Chetter, I. (2015). Infection in prosthetic material. Surgery (Oxford), 33(11), 559-564. https://doi.org/10.1016/j.mpsur.2015.08.003

Surgical site infection (SSI) occurs when a wound created as part of a surgical procedure becomes infected. SSI is one of the most common healthcare-associated infections and occurs in approximately 5% of patients undergoing a surgical procedure. SSI... Read More about Infection in prosthetic material.

A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation (2015)
Journal Article
Barnes, R., Smith, G. E., & Chetter, I. C. (2015). A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation. The journal of vascular access, 16(5), 372-376. https://doi.org/10.5301/jva.5000401

Purpose: Arteriovenous fistula (AVF) surgery affords an excellent opportunity for junior surgeons to learn key vascular techniques. However, implementation of the European Working Time Directive has reduced trainee surgeon’s working hours, leading to... Read More about A prospective observational study to assess the impact of operator seniority on outcome following arteriovenous fistula formation.