Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials

Temel, Jennifer S; Abernethy, Amy P; Currow, David C.; Friend, John; Duus, Elizabeth M; Yan, Ying; Fearon, Kenneth C

Abstract

© 2016 Elsevier Ltd Background Patients with advanced cancer frequently experience anorexia and cachexia, which are associated with reduced food intake, altered body composition, and decreased functionality. We assessed anamorelin, a novel ghrelin-receptor agonist, on cachexia in patients with advanced non-small-cell lung cancer and cachexia. Methods ROMANA 1 and ROMANA 2 were randomised, double-blind, placebo-controlled phase 3 trials done at 93 sites in 19 countries. Patients with inoperable stage III or IV non-small-cell lung cancer and cachexia (defined as ≥5% weight loss within 6 months or body-mass index

Citation

Temel, J. S., Abernethy, A. P., Currow, D. C., Friend, J., Duus, E. M., Yan, Y., & Fearon, K. C. (2016). Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials. The lancet oncology, 17(4), 519-531. https://doi.org/10.1016/S1470-2045%2815%2900558-6

• Journal Article Type: Article
• Online Publication Date: Feb 20, 2016
• Publication Date: Apr 1, 2016
• Deposit Date: Apr 9, 2019
• Journal: The Lancet Oncology
• Print ISSN: 1470-2045
• Electronic ISSN: 1474-5488
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 4
• Pages: 519-531
• DOI: https://doi.org/10.1016/S1470-2045%2815%2900558-6
• Public URL: https://hull-repository.worktribe.com/output/1563315
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1470204515005586?via%3Dihub
• Additional Information: This article is maintained by: Elsevier; Article Title: Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials; Journal Title: The Lancet Oncology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/S1470-2045(15)00558-6; CrossRef DOI link to the associated document: https://doi.org/10.1016/S1470-2045(16)00085-1; Content Type: article; Copyright: Copyright © 2016 Elsevier Ltd. All rights reserved.