Skip to main content

Research Repository

Advanced Search

All Outputs (454)

Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study (2019)
Journal Article
White, C., Noble, S. I. R., Watson, M., Swan, F., Allgar, V. L., Napier, E., Nelson, A., McAuley, J., Doherty, J., Lee, B., & Johnson, M. J. (2019). Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study. The Lancet Haematology, 6(2), e79-e88. https://doi.org/10.1016/S2352-3026%2818%2930215-1

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Background: The prevalence of deep venous thrombosis in patients with advanced cancer is unconfirmed and it is unknown whether current i... Read More about Prevalence, symptom burden, and natural history of deep vein thrombosis in people with advanced cancer in specialist palliative care units (HIDDen): a prospective longitudinal observational study.

Twelve tips for developing palliative care teaching in an undergraduate curriculum for medical students (2019)
Journal Article
Boland, J. W., Barclay, S., & Gibbins, J. (2019). Twelve tips for developing palliative care teaching in an undergraduate curriculum for medical students. Medical Teacher, 41(12), 1359-1365. https://doi.org/10.1080/0142159X.2018.1533243

Palliative care is the holistic care of patients with advanced, progressive incurable illness. Palliative care is well recognized as an essential component of medical student curricula. However, teaching is variable within medical schools. Using curr... Read More about Twelve tips for developing palliative care teaching in an undergraduate curriculum for medical students.

Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK (2019)
Journal Article
Allgar, V. L., Oliver, S. E., Chen, H., Oviasu, O., Johnson, M. J., & Macleod, U. (2019). Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK. Cancer epidemiology, 59, 37-45. https://doi.org/10.1016/j.canep.2019.01.008

© 2019 Elsevier Ltd Background: England has significantly higher mortality risks due to Head and Neck Cancer (HNC) compared with other European countries. Early diagnosis is important as it is likely to increase early-stage diagnosis and improve surv... Read More about Time intervals from first symptom to diagnosis for head and neck cancers: An analysis of linked patient reports and medical records from the UK.

Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex (2019)
Journal Article
Benelhaj, N. E., Maraveyas, A., Featherby, S., Collier, M. E., Johnson, M. J., & Ettelaie, C. (2019). Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex. Thrombosis Research, 175, 13-20. https://doi.org/10.1016/j.thromres.2019.01.009

Alterations in the endothelial permeability occur in response to the activation of coagulation mechanisms in order to control clot formation. The activation of the protease activated receptors (PAR) can induce signals that regulate such cellular resp... Read More about Alteration in endothelial permeability occurs in response to the activation of PAR2 by factor Xa but not directly by the TF-factor VIIa complex.

Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study (2019)
Journal Article
Ekström, M., Williams, M., Johnson, M. J., Huang, C., & Currow, D. C. (2019). Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study. Journal of pain and symptom management, 57(4), 715-723.e5. https://doi.org/10.1016/j.jpainsymman.2019.01.001

Context: Chronic breathlessness is a cardinal symptom in cardiopulmonary disease where both overall intensity or severity (S) and unpleasantness (U) are commonly quantified. Objective: We aimed to evaluate agreement between breathlessness severity an... Read More about Agreement between breathlessness severity and unpleasantness in people with chronic breathlessness: A longitudinal clinical study.

Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies (2019)
Journal Article
Buture, A., Boland, J. W., Dikomitis, L., & Ahmed, F. (2019). Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies. Journal of Pain Research, 12, 269-281. https://doi.org/10.2147/JPR.S175312

Objective: Cluster headache (CH) is the most severe primary headache condition. Its pathophysiology is multifaceted and incompletely understood. This review brings together the latest neuroimaging and neuropeptide evidence on the pathophysiology of C... Read More about Update on the pathophysiology of cluster headache: Imaging and neuropeptide studies.

Identifying potentially inappropriate prescribing in older people with dementia: a systematic review (2019)
Journal Article
Hukins, D., Macleod, U., & Boland, J. W. (2019). Identifying potentially inappropriate prescribing in older people with dementia: a systematic review. European Journal of Clinical Pharmacology, 75(4), 467-481. https://doi.org/10.1007/s00228-018-02612-x

Purpose: Older people with dementia are at risk of adverse events associated with potentially inappropriate prescribing. Aim: to describe (1) how international tools designed to identify potentially inappropriate prescribing have been used in studies... Read More about Identifying potentially inappropriate prescribing in older people with dementia: a systematic review.

Invisible and intangible illness: A qualitative interview study of patients’ experiences and understandings of conservatively managed end-stage kidney disease (2019)
Journal Article
Bristowe, K., Selman, L. E., Higginson, I. J., & Murtagh, F. E. (2019). Invisible and intangible illness: A qualitative interview study of patients’ experiences and understandings of conservatively managed end-stage kidney disease. Annals of palliative medicine, 8(2), 121-129. https://doi.org/10.21037/apm.2018.12.06

Background: Increasing numbers of older adults are living with kidney disease. For those with comorbidities, conservative management of end-stage kidney disease is a viable option: dialysis may afford limited or no survival benefit, and perceived bur... Read More about Invisible and intangible illness: A qualitative interview study of patients’ experiences and understandings of conservatively managed end-stage kidney disease.

No excess harms from sustained-release morphine: A randomised placebo-controlled trial in chronic breathlessness (2019)
Journal Article
Johnson, M. J., Sbizzera, I., Fairhurst, C., Agar, M., Fazekas, B., Agar, M. R., Ekström, M., & Currow, D. C. (2019). No excess harms from sustained-release morphine: A randomised placebo-controlled trial in chronic breathlessness. BMJ supportive & palliative care, 10(4), 421-428. https://doi.org/10.1136/bmjspcare-2019-002009

© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ. Objectives: We aimed to identify and evaluate: (1) treatment-emergent adverse events (TEAE (worse or new since baseline)) and the subgroup of... Read More about No excess harms from sustained-release morphine: A randomised placebo-controlled trial in chronic breathlessness.

Collaborative knowledge creation and use: Common threads in diverse global fields (2019)
Journal Article
Pearson, M., & Smith, K. E. (2019). Collaborative knowledge creation and use: Common threads in diverse global fields. Evidence and Policy, 15(2), 175-177. https://doi.org/10.1332/174426419X15536702270103

This study explores how involving education leaders in the process of research can enhance the practical value of research for them. This paper describes: 1) a design process used for engaging US state science leaders in participatory research; and 2... Read More about Collaborative knowledge creation and use: Common threads in diverse global fields.

A life or “good death” situation? A worldwide ecological study of the national contexts of countries that have and have not implemented palliative care (2018)
Journal Article
Clark, J., Barnes, A., Campbell, M., & Gardiner, C. (2019). A life or “good death” situation? A worldwide ecological study of the national contexts of countries that have and have not implemented palliative care. Journal of pain and symptom management, 57(4), 793-801. https://doi.org/10.1016/j.jpainsymman.2018.12.007

Context: Palliative care advocates argue that service implementation is feasible in all settings. Yet, services have developed patchily in low- and middle-income settings. Beyond Human Development Index indicators, there has been limited engagement w... Read More about A life or “good death” situation? A worldwide ecological study of the national contexts of countries that have and have not implemented palliative care.

Finding a ‘new normal’ following acute illness: A qualitative study of influences on frail older people’s care preferences (2018)
Journal Article
Etkind, S. N., Lovell, N., Nicholson, C. J., Higginson, I. J., & Murtagh, F. E. (2019). Finding a ‘new normal’ following acute illness: A qualitative study of influences on frail older people’s care preferences. Palliative medicine, 33(3), 301-311. https://doi.org/10.1177/0269216318817706

Background: The frail older population is growing, and many frail older people have episodes of acute illness. Patient preferences are increasingly considered important in the delivery of person-centred care and may change following acute illness. Ai... Read More about Finding a ‘new normal’ following acute illness: A qualitative study of influences on frail older people’s care preferences.

Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review (2018)
Journal Article
Miller, J., Wells, L., Nwulu, U., Currow, D., Johnson, M. J., & Skipworth, R. J. (2018). Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review. American Journal of Clinical Nutrition, 108(6), 1196-1208. https://doi.org/10.1093/ajcn/nqy244

Background: There is great overlap between the presentation of cachexia, sarcopenia, and malnutrition. Distinguishing between these conditions would allow for better targeted treatment for patients. Objectives: The aim was to systematically review va... Read More about Validated screening tools for the assessment of cachexia, sarcopenia, and malnutrition: a systematic review.

Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial (2018)
Journal Article
Hutchinson, A., Rees, S., Young, A., Maraveyas, A., Date, K., & Johnson, M. J. (2019). Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial. Palliative medicine, 33(5), 510-517. https://doi.org/10.1177/0269216318815377

Background: Cancer patients have a four- to fivefold greater risk of thrombosis than the general population. Recommended treatment for cancer-associated thrombosis is 3–6 months of low-molecular-weight heparin. The ‘select-d’ trial is an open-label,... Read More about Oral anticoagulation is preferable to injected, but only if it is safe and effective: An interview study of patient and carer experience of oral and injected anticoagulant therapy for cancer-associated thrombosis in the select-d trial.

Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study (2018)
Journal Article
Boland, J. W., Allgar, V., Boland, E. G., Kaasa, S., Hjermstad, M. J., & Johnson, M. J. (2019). Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study. Palliative medicine, 33(2), 206-212. https://doi.org/10.1177/0269216318811011

Background: Performance status, a predictor of cancer survival, and ability to maintain independent living deteriorate in advanced disease. Understanding predictors of performance status trajectory could help identify those at risk of functional dete... Read More about Predictors and trajectory of performance status in patients with advanced cancer: A secondary data analysis of the international European Palliative Care Cancer Symptom study.